Social stress and asthma: The role of corticosteroid insensitivity
Open accessAbstract
Psychosocial stress alters susceptibility to infectious and systemic illnesses and may enhance airway inflammation in asthma by modulating immune cell function through neural and hormonal pathways. Stress activates the hypothalamic-pituitary-adrenal axis. Release of endogenous glucocorticoids, as a consequence, may play a prominent role in altering the airway immune homeostasis. Despite substantial corticosteroid and catecholamine plasma levels, chronic psychosocial stress evokes asthma exacerbations. Animal studies suggest that social stress induces corticosteroid insensitivity that in part may be a result of impaired glucocorticoid receptor expression and/or function. Such mechanisms likely promote and amplify airway inflammation in response to infections, allergen, or irritant exposure. This review discusses evidence of an altered corticosteroid responsive state as a consequence of chronic psychosocial stress. Elucidation of the mechanisms of stress-induced impairment of glucocorticoid responsiveness and immune homeostasis may identify novel therapeutic targets that could improve asthma management.
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Previous studies found that several factors contribute to the risk of developing asthma, including obesity, female sex, high levels of family stress, and IPV.
“Previous studies found that several factors contribute to the risk of developing asthma, including obesity, female sex, high levels of family stress, and IPV [86,87,88]”
From The Risk Factors of Chronic Pain in Victims of Violence: A Scoping Review (2023) · cites this paper as [87]
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References 118 · Cited by 128
Research works printed but not linked: 1
- [43]Bailey MT Kierstein S Spaits M Sheridan JF Panettieri RAJ Haczku A Social Stress Enhances Allergen-Induced Airway Inflammation in Mice Am J Respir Crit Care Med 2006 A237 PMC2767120 19494313
- Authors
- Haczku, A., & Panettieri, R. A.
- Affiliations
- University of Pennsylvania (US)
- Corresponding author
- Haczku, Angela
- Venue
- Journal of Allergy and Clinical Immunology
- Publisher
- Elsevier BV
- Published
- 2010-03
- Volume
- 125
- Issue
- 3
- Pages
- 550-558
- ISSN
- 0091-6749 (ISSN-L)
- PMC
- PMC2839059
- OpenAlex
- W2039354557
- Cited by
- 128
- References
- 118
- Citations by year
- 2026: 5 · 2025: 4 · 2024: 5 · 2023: 6 · 2022: 7 · 2021: 8 · 2020: 5 · 2019: 10 · 2018: 6 · 2017: 9 · 2016: 7 · 2015: 7 · 2014: 10 · 2013: 9 · 2012: 14
- FWCI
- 1.25
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Journal of Allergy and Clinical Immunology (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Heart, Lung, and Blood Institute (R01HL076646)
- National Institute of Allergy and Infectious Diseases (R01AI055593)
- National Institute of Environmental Health Sciences (RC1ES018505)
- Topics
- Health Sciences › Medicine › Physiology › Asthma and respiratory diseases
- Life Sciences › Neuroscience › Behavioral Neuroscience › Stress Responses and Cortisol
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Adrenal Hormones and Disorders
- Keywords
- asthma, psychosocial stress, social stress, corticosteroid insensitivity, glucocorticoid receptor, hypothalamic-pituitary-adrenal axis, airway inflammation, asthma exacerbations, immune homeostasis, catecholamines, glucocorticoid responsiveness
- MeSH terms
- Adrenal Cortex Hormones, Animals, Asthma, Glucocorticoids, Humans, Hypothalamo-Hypophyseal System, Immunity, Innate, Pituitary-Adrenal System, Receptors, Glucocorticoid, Stress, Psychological, Neuroimmunomodulation, Anti-Asthmatic Agents
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