The who, where, and when of IgE in allergic airway disease
Open accessAbstract
Allergic asthma and allergic rhinitis/conjunctivitis are characterized by a T(H)2-dominated immune response associated with increased serum IgE levels in response to inhaled allergens. Because IgE is a key player in the induction and maintenance of allergic inflammation, it represents a prime target for therapeutic intervention. However, our understanding of IgE biology remains fragmentary. This article puts together our current knowledge on IgE in allergic airway diseases with a special focus on the identity of IgE-secreting cells ("who"), their location ("where"), and the circumstances in which they are induced ("when"). We further consider the therapeutic implications of the insights gained.
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
The rate of local IgE production is sufficient to saturate IgE receptors on local mast cells and potentially spill over into the circulation.
“The rate of local IgE production316 is sufficient to saturate IgE receptors on local mast cells, and potentially spill over into the circulation.316,317”
From International Consensus Statement on Allergy and Rhinology: Allergic Rhinitis (2018) · cites this paper as [317]
The 'When' section says locally produced IgE binds receptors on airway mucosal cells, including mast cells. The 'Where' section discusses possible spillover of mucosally produced IgE into the circulation. Neither passage establishes that the rate of production is sufficient to saturate mast-cell receptors; page numbers are unavailable in our copy. (LLM, conf=0.84)
Experimental — accuracy not yet measured
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
The citation lists haven’t been fetched yet
References 106 · Cited by 194
Research works printed but not linked: 4
- Ganzer U, Bachert C. Localization of IgE synthesis in immediate-type allergy of the upper respiratory tract. ORL J Otorhinolaryngol Relat Spec 1988;50:257-64.
- Smurthwaite L, Walker SN, Wilson DR, Birch DS, Merrett TG, Durham SR, et al. Persistent IgE synthesis in the nasal mucosa of hay fever patients. Eur J Immunol 2001;31:3422-31.
- Snow RE, Chapman CJ, Holgate ST, Stevenson FK. Clonally related IgE and IgG4 transcripts in blood lymphocytes of patients with asthma reveal differing patterns of somatic mutation. Eur J Immunol 1998;28:3354-61.
- Luger E, Lamers M, Achatz-Straussberger G, Geisberger R, Infuhr D, Breiten- bach M, et al. Somatic diversity of the immunoglobulin repertoire is controlled in an isotype-specific manner. Eur J Immunol 2001;31:2319-30.
- Authors
- Dullaers, M., De Bruyne, R., Ramadani, F., Gould, H. J., Gevaert, P., & Lambrecht, B. N.
- Affiliations
- King's College London (GB)
- Ghent University (BE)
- Ghent University Hospital (BE)
- Venue
- Journal of Allergy and Clinical Immunology
- Publisher
- Elsevier BV
- Published
- 2012-03
- Volume
- 129
- Issue
- 3
- Pages
- 635-645
- ISSN
- 0091-6749 (ISSN-L)
- OpenAlex
- W1994268130
- Cited by
- 194
- References
- 106
- Citations by year
- 2026: 5 · 2025: 6 · 2024: 13 · 2023: 10 · 2022: 11 · 2021: 21 · 2020: 14 · 2019: 14 · 2018: 14 · 2017: 10 · 2016: 21 · 2015: 17 · 2014: 16 · 2013: 20 · 2012: 2
- FWCI
- 1.30
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Journal of Allergy and Clinical Immunology (publishedVersion)
- PubMed (publishedVersion)
- Ghent University Academic Bibliography (Ghent University) (submittedVersion)
- Research Portal (King's College London) (submittedVersion)
- Funders
- Wellcome Trust
- National Institute for Health and Care Research (NF-SI-0508-10212)
- Directorate for Biological Sciences
- Medical Research Council
- Topics
- Health Sciences › Medicine › Physiology › Asthma and respiratory diseases
- Health Sciences › Medicine › Immunology and Allergy › Allergic Rhinitis and Sensitization
- Life Sciences › Immunology and Microbiology › Immunology › Mast cells and histamine
- Keywords
- IgE, allergic airway disease, allergic asthma, allergic rhinitis, allergic conjunctivitis, Th2 immune response, aeroallergens, allergic inflammation
- MeSH terms
- Animals, Cell Differentiation, Cell Movement, Humans, Immunoglobulin E, Plasma Cells, Respiratory Hypersensitivity, Molecular Targeted Therapy
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
