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IL-33 promotes airway remodeling in pediatric patients with severe steroid-resistant asthma
Open accessAbstract
Background TH2 cytokines are not responsible for the ongoing symptoms and pathology in children with severe therapy-resistant asthma (STRA). IL-33 induces airway hyperresponsiveness, but its role in airway remodeling and steroid resistance is unknown. Objective We sought to investigate the relationship between IL-33 and airway remodeling in pediatric patients with STRA. Methods IL-33 levels were quantified in neonatal mice given inhaled house dust mite (HDM), and the effect of blocking IL-13 on remodeling and IL-33 levels was assessed. HDM-induced allergic airways disease (AAD) in neonatal ST2(-/-) mice lacking the IL-33 receptor was assessed, together with collagen production after IL-33 administration. The effect of steroid therapy on IL-33 levels in patients with neonatal AAD was explored. IL-33 expression was quantified in endobronchial biopsy (EB) specimens from children with STRA and related to remodeling, and collagen production by airway fibroblasts from pediatric patients stimulated with IL-33 and budesonide was quantified. Results Blocking IL-13 after AAD was established in neonatal mice and did not reduce remodeling or IL-33 levels; airway hyperresponsiveness was only partially reduced. IL-33 promoted collagen synthesis both from asthmatic fibroblasts from pediatric patients and after intranasal administration in mice. Increased cellular expression of IL-33, but not IL-13, was associated with increased reticular basement membrane thickness in EB specimens from children with STRA, whereas remodeling was absent in HDM-exposed ST2(-/-) mice. IL-33 levels were maintained, whereas IL-13 levels were abrogated by steroid treatment in neonatal HDM-exposed mice and in EB specimens from children with STRA. Conclusion IL-33 is a relatively steroid-resistant mediator that promotes airway remodeling in patients with STRA and is an important therapeutic target.
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“It has been shown that SAA/IL-33 play a role in the pathology of steroid-resistant lung inflammation [6,15].”
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“Moreover, IL-33 has been implicated as a steroid-resistant mediator that promotes airway remodeling in patients with severe therapy-resistant asthma [15].”
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Cites
A Large-Scale, Consortium-Based Genomewide Association Study of Asthma
Moffatt, M. F., Gut, I. G., Démenais, F., Strachan, D. P., Bouzigon, E., Heath, S. C., von Mutius, E., Farrall, M., Lathrop, M. G., & Cookson, W. (2010) · New England Journal of Medicine · doi:10.1056/nejmoa0906312 · Cited by 2,043
Lebrikizumab Treatment in Adults with Asthma
Corren, J., Lemanske, R. F., Hanania, N. A., Korenblat, P. E., Parsey, M. V., Arron, J. R., Harris, J. M., Scheerens, H., Wu, L. C., Su, Z., et al. (2011) · New England Journal of Medicine · doi:10.1056/nejmoa1106469 · Cited by 1,535
Innate and adaptive immune responses in asthma
Holgate, S. T. (2012) · Nature Medicine · doi:10.1038/nm.2731 · Cited by 942
Chang, Y., Kim, H. Y., Albacker, L. A., Baumgarth, N., McKenzie, A. N. J., Smith, D. E., DeKruyff, R. H., & Umetsu, D. T. (2011) · Nature Immunology · doi:10.1038/ni.2045 · Cited by 797
Interleukin‐13 in asthma pathogenesis
Wills‐Karp, M. (2004) · Immunological Reviews · doi:10.1111/j.0105-2896.2004.00215.x · Cited by 683
Increased expression of IL-33 in severe asthma: evidence of expression by airway smooth muscle cells
Préfontaine, D., Lajoie-Kadoch, S., Foley, S., Audusseau, S., Olivenstein, R., Halayko, A. J., Lemière, C., Martin, J. G., & Hamid, Q. (2009) · The Journal of Immunology · doi:10.4049/jimmunol.0802387 · Cited by 538
Early Detection of Airway Wall Remodeling and Eosinophilic Inflammation in Preschool Wheezers
Saglani, S., Payne, D., Zhu, J., Wang, Z., Nicholson, A. G., Bush, A., & Jeffery, P. K. (2007) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/rccm.200702-212oc · Cited by 511
Self-citationEarly Thickening of the Reticular Basement Membrane in Children with Difficult Asthma
Payne, D., Rogers, A. V., Adelroth, E. C., Bandi, V., Guntupalli, K. K., Bush, A., & Jeffery, P. K. (2002) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/rccm.200205-414oc · Cited by 504
Self-citationBarlow, J. L., Bellosi, A., Hardman, C. S., Drynan, L. F., Wong, S. H., Cruickshank, J., & McKenzie, A. N. J. (2011) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2011.09.041 · Cited by 474
Increased IL-33 expression by epithelial cells in bronchial asthma
Préfontaine, D., Nadigel, J., Chouiali, F., Audusseau, S., Semlali, A., Chakir, J., Martin, J. G., & Hamid, Q. A. (2010) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2009.12.935 · Cited by 469
Pediatric severe asthma is characterized by eosinophilia and remodeling without TH2 cytokines
Bossley, C. J., Fleming, L., Gupta, A. K., Regamey, N., Frith, J., Oates, T., Tsartsali, L., Lloyd, C. M., Bush, A., & Saglani, S. (2012) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2012.01.059 · Cited by 316
Self-citationKim, H. Y., Chang, Y., Subramanian, S., Lee, H.-H., Albacker, L. A., Matangkasombut, P., Savage, P. B., McKenzie, A. N. J., Smith, D. E., Rottman, J. B., et al. (2011) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2011.10.036 · Cited by 314
IL-33 Exacerbates Eosinophil-Mediated Airway Inflammation
Stolarski, B., Kurowska‐Stolarska, M., Kewin, P., Xu, D., & Liew, F. Y. (2010) · The Journal of Immunology · doi:10.4049/jimmunol.1000730 · Cited by 291
Airway Inflammation in Childhood Asthma
Barbato, A., Turato, G., Baraldo, S., Bazzan, E., Calabrese, F., Tura, M., Zuin, R., Beghé, B., Maestrelli, P., Fabbri, L. M., et al. (2003) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/rccm.200305-650oc · Cited by 207
IL-33 family members and asthma – bridging innate and adaptive immune responses
Lloyd, C. M. (2010) · Current Opinion in Immunology · doi:10.1016/j.coi.2010.10.006 · Cited by 162
Self-citationWhat effect does asthma treatment have on airway remodeling? Current perspectives
Durrani, S. R., Viswanathan, R. K., & Busse, W. W. (2011) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2011.06.002 · Cited by 159
Halwani, R., Al‐Muhsen, S., & Hamid, Q. A. (2010) · Current Opinion in Pharmacology · doi:10.1016/j.coph.2010.06.004 · Cited by 158
Regamey, N., Ochs, M., Hilliard, T. N., Mühlfeld, C., Cornish, N., Fleming, L., Saglani, S., Alton, E. W. F. W., Bush, A., Jeffery, P. K., et al. (2008) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/rccm.200707-977oc · Cited by 156
Self-citationKicic, A., Hallstrand, T. S., Sutanto, E. N., Stevens, P. T., Kobor, M. S., Taplin, C., Paré, P. D., Beyer, R. P., Stick, S. M., & Knight, D. A. (2010) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/rccm.200907-1071oc · Cited by 156
Yanaba, K., Yoshizaki, A., Asano, Y., Kadono, T., & Sato, S. (2011) · Clinical Rheumatology · doi:10.1007/s10067-011-1686-5 · Cited by 142
On the functional consequences of bronchial basement membrane thickening
Milanese, M., Crimi, E., Scordamaglia, A., Riccio, A., Pellegrino, R., Canonica, G. W., & Brusasco, V. (2001) · Journal of Applied Physiology · doi:10.1152/jappl.2001.91.3.1035 · Cited by 125
Inhaled house dust mite induces pulmonary T helper 2 cytokine production
Gregory, L. G., Causton, B., Murdoch, J. R., Mathie, S. A., O’Donnell, V. B., Thomas, C. P., Priest, F., Quint, D. J., & Lloyd, C. M. (2009) · Clinical & Experimental Allergy · doi:10.1111/j.1365-2222.2009.03302.x · Cited by 113
Self-citationLiew, F. Y. (2012) · Annals of the Rheumatic Diseases · doi:10.1136/annrheumdis-2011-200589 · Cited by 101
Economic burden of impairment in children with severe or difficult-to-treat asthma
Szefler, S. J., Zeiger, R. S., Haselkorn, T., Mink, D. R., Kamath, T. V., Fish, J. E., & Chipps, B. E. (2011) · Annals of Allergy Asthma & Immunology · doi:10.1016/j.anai.2011.04.008 · Cited by 100
Pathophysiological Features of Asthma Develop in Parallel in House Dust Mite–Exposed Neonatal Mice
Saglani, S., Mathie, S. A., Gregory, L. G., Bell, M. J., Bush, A., & Lloyd, C. M. (2009) · American Journal of Respiratory Cell and Molecular Biology · doi:10.1165/rcmb.2008-0396oc · Cited by 98
Self-citationUltrastructure of the reticular basement membrane in asthmatic adults, children and infants
Saglani, S., Molyneux, C., Gong, H., Rogers, A. V., Malmström, K., Pelkonen, A. S., Mäkelä, M. J., Adelroth, E. C., Bush, A., Payne, D., et al. (2006) · European Respiratory Journal · doi:10.1183/09031936.06.00056405 · Cited by 71
Self-citationNuocytes: expanding the innate cell repertoire in type-2 immunity
Barlow, J. L., & McKenzie, A. N. J. (2011) · Journal of Leukocyte Biology · doi:10.1189/jlb.0311160 · Cited by 70
Noneosinophilic asthma in children: relation with airway remodelling
Baraldo, S., Turato, G., Bazzan, E., Ballarin, A., Damin, M., Balestro, E., Oliani, K. L., Calabrese, F., Maestrelli, P., Snijders, D., et al. (2011) · European Respiratory Journal · doi:10.1183/09031936.00168210 · Cited by 70
IL-33 regulates TNF-α dependent effects in synovial fibroblasts
Kunisch, E., Chakilam, S., Gandesiri, M., & Kinne, R. W. (2012) · International Journal of Molecular Medicine · doi:10.3892/ijmm.2012.883 · Cited by 66
Tomlinson, K. L., Davies, G., Sutton, D. J., & Palframan, R. T. (2010) · PLoS ONE · doi:10.1371/journal.pone.0013136 · Cited by 64
Is Interleukin-13 Critical in Maintaining Airway Hyperresposiveness in Allergen-challenged Mice?
Leigh, R., Ellis, R., Wattie, J. N., Donaldson, D. D., & Inman, M. D. (2004) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/rccm.200311-1488oc · Cited by 61
Long-term effectiveness of a staged assessment for paediatric problematic severe asthma
Sharples, J., Gupta, A. K., Fleming, L., Bossley, C. J., Bracken-King, M., Hall, P., Hayward, A., Puckey, M., Balfour-Lynn, I. M., Rosenthal, M., et al. (2012) · European Respiratory Journal · doi:10.1183/09031936.00209511 · Cited by 60
Self-citationLiou, C., & Huang, W. (2011) · Journal of Clinical Immunology · doi:10.1007/s10875-011-9529-3 · Cited by 55
Effects of interleukin-33 on cardiac fibroblast gene expression and activity
Zhu, J., & Carver, W. E. (2012) · Cytokine · doi:10.1016/j.cyto.2012.02.008 · Cited by 49
Choi, I. S., Cui, Y., Koh, Y.-A., Lee, H., Cho, Y.-B., & Won, Y.-H. (2008) · The Korean Journal of Internal Medicine · doi:10.3904/kjim.2008.23.4.176 · Cited by 46
BOURDIN, A. A., Kleis, S., Chakra, M., Vachier, I., Paganin, F., Godard, P., & Chanez, P. (2011) · CHEST Journal · doi:10.1378/chest.11-0232 · Cited by 29
Effect of Ciclesonide Treatment on Allergen-Induced Changes in T Cell Regulation in Asthma
Heijink, I. H., Kauffman, H. F., Vellenga, E., Veltman-Starkenburg, C. A., Postma, D. S., & de Monchy, J. G. R. (2007) · International Archives of Allergy and Immunology · doi:10.1159/000108136 · Cited by 13
Research works printed but not linked: 2
- Saglani, 2009, Pathophysiological features of asthma develop in parallel in house dust mite exposed neonatal mice, Am J Respir Cell Mol Biol, 41, 281, 10.1165/rcmb.2008-0396OC · DOI
- Bossley, 2012, Pediatric severe asthma is characterized by eosinophilia and remodeling without T(H)2 cytokines, J Allergy Clin Immunol, 129, 974, 10.1016/j.jaci.2012.01.059 · DOI
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Scadding, G. K., Kariyawasam, H. H., Scadding, G. K., Mirakian, R. M., Buckley, R., Dixon, T. A., Durham, S. R., Farooque, S. P., Jones, N. S., Leech, S. C., et al. (2017) · Clinical & Experimental Allergy · doi:10.1111/cea.12953 · Cited by 371
Perinatal Activation of the Interleukin-33 Pathway Promotes Type 2 Immunity in the Developing Lung
de Kleer, I. M., Kool, M., de Bruijn, M. J. W., Willart, M. A. M., Moorleghem, J. V., Schuijs, M. J., Plantinga, M., Beyaert, R., Hams, E., Fallon, P. G., et al. (2016) · Immunity · doi:10.1016/j.immuni.2016.10.031 · Cited by 347
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Lloyd, C. M., & Snelgrove, R. J. (2018) · Science Immunology · doi:10.1126/sciimmunol.aat1604 · Cited by 338
Self-citationIL33: Roles in Allergic Inflammation and Therapeutic Perspectives
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Metadata
- Authors
- Saglani, S., Lui, S., Ullmann, N., Campbell, G. A., Sherburn, R. T., Mathie, S. A., Denney, L., Bossley, C. J., Oates, T., Walker, S. A., Bush, A., & Lloyd, C. M.
- Affiliations
- Royal Brompton Hospital (GB)
- Imperial College London (GB)
- Corresponding author
- Lloyd, Clare M.
- ORCID
- Venue
- Journal of Allergy and Clinical Immunology
- Publisher
- Elsevier BV
- Published
- 2013-09
- Volume
- 132
- Issue
- 3
- Pages
- 676-685.e13
- ISSN
- 0091-6749 (ISSN-L)
- PMC
- PMC4218948
- OpenAlex
- W2030003617
- Cited by
- 258
- References
- 37
- Citations by year
- 2026: 6 · 2025: 12 · 2024: 12 · 2023: 11 · 2022: 14 · 2021: 27 · 2020: 22 · 2019: 34 · 2018: 19 · 2017: 30 · 2016: 20 · 2015: 23 · 2014: 25 · 2013: 2
- FWCI
- 10.20
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Journal of Allergy and Clinical Immunology (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Funders
- Wellcome Trust (087618)
- National Institute for Health and Care Research (NF-SI-0510-10192)
- Medical Research Council (MR/J010529/1)
- Topics
- Life Sciences › Immunology and Microbiology › Immunology › IL-33, ST2, and ILC Pathways
- Health Sciences › Medicine › Pulmonary and Respiratory Medicine › Asthma and respiratory diseases
- Health Sciences › Medicine › Dermatology › Dermatology and Skin Diseases
- Keywords
- IL-33, airway remodeling, steroid-resistant asthma, childhood asthma, IL-13, allergic airway disease, house dust mites, airway hyperresponsiveness, collagen synthesis, airway fibroblasts, budesonide, bronchial biopsy
- MeSH terms
- Interleukin-33, Adolescent, Animals, Animals, Newborn, Anti-Inflammatory Agents, Asthma, Child, Collagen, Drug Resistance, Female, Glucocorticoids, Humans, Interleukins, Male, Mice, Inbred BALB C, Bronchial Hyperreactivity, Mice, Knockout, Interleukin-13, Budesonide, Pyroglyphidae, Mice, Airway Remodeling
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