The DOI matches its Crossref record; 76 of the 76 references it cites were found in a registry or an index.
Respiratory allergy caused by house dust mites: What do we really know?
Open accessAbstract
The house dust mite (HDM) is a major perennial allergen source and a significant cause of allergic rhinitis and allergic asthma. However, awareness of the condition remains generally low. This review assesses the links between exposure to HDM, development of the allergic response, and pathologic consequences in patients with respiratory allergic diseases. We investigate the epidemiology of HDM allergy to explore the interaction between mites and human subjects at the population, individual, and molecular levels. Core and recent publications were identified by using "house dust mite" as a key search term to evaluate the current knowledge of HDM epidemiology and pathophysiology. Prevalence data for HDM allergen sensitization vary from 65 to 130 million persons in the general population worldwide to as many as 50% among asthmatic patients. Heterogeneity of populations, terminology, and end points in the literature confound estimates, indicating the need for greater standardization in epidemiologic research. Exposure to allergens depends on multiple ecological strata, including climate and mite microhabitats within the domestic environment, with the latter providing opportunity for intervention measures to reduce allergen load. Inhaled mite aeroallergens are unusually virulent: they are able to activate both the adaptive and innate immune responses, potentially offering new avenues for intervention. The role of HDM allergens is crucial in the development of allergic rhinitis and asthma, but the translation of silent sensitization into symptomatic disease is still incompletely understood. Improved understanding of HDMs, their allergens, and their microhabitats will enable development of more effective outcomes for patients with HDM allergy.
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Cites
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Cited by
Scadding, G. K., Kariyawasam, H. H., Scadding, G., Mirakian, R., Buckley, R. J., Dixon, T., Durham, S. R., Farooque, S., Jones, N., Leech, S., et al. (2017) · Clinical & Experimental Allergy · doi:10.1111/cea.12953 · Cited by 359
Posa, D., Perna, S., Resch, Y., Lupinek, C., Panetta, V., Hofmaier, S., Rohrbach, A., Hatzler, L., Grabenhenrich, L., Tsilochristou, O., et al. (2017) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2016.08.014 · Cited by 281
The role of dust mites in allergy
Miller, J. D. (2019) · Clinical Reviews in Allergy & Immunology · doi:10.1007/s12016-018-8693-0 · Cited by 250
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Self-citationSbihi, H., Boutin, R. C., Cutler, C., Suen, M., Finlay, B. B., & Turvey, S. E. (2019) · Allergy · doi:10.1111/all.13812 · Cited by 199
Metadata
- Authors
- Calderón, M. A., Linneberg, A., Kleine-Tebbe, J., De Blay, F., Hernandez Fernandez de Rojas, D., Virchow, J. C., & Demoly, P.
- Venue
- Journal of Allergy and Clinical Immunology
- Publisher
- Elsevier BV
- Published
- 2015-07
- Volume
- 136
- Issue
- 1
- Pages
- 38-48
- ISSN
- 0091-6749 (ISSN-L)
- OpenAlex
- W1969980812
- Cited by
- 553
- References
- 76
- FWCI
- 21.15
- Type
- journal article
- Language
- en
- Open access
- hybrid
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- Calderón, M. A., Linneberg, A., Kleine-Tebbe, J., De Blay, F., Hernandez Fernandez de Rojas, D., Virchow, J. C., & Demoly, P. (2015). Respiratory allergy caused by house dust mites: What do we really know? Journal of Allergy and Clinical Immunology. https://doi.org/10.1016/j.jaci.2014.10.012
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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