Solitary chemosensory cells are a primary epithelial source of IL-25 in patients with chronic rhinosinusitis with nasal polyps

Kohanski, Michael A.; Workman, Alan D.; Patel, Neil N.; Hung, Li-Yin; Shtraks, Julie P.; Chen, Bei; Blasetti, Mariel; Doghramji, Laurel; Kennedy, David W.; Adappa, Nithin D.; Palmer, James N.; Herbert, De'Broski R.; Cohen, Noam A.

doi:10.1016/j.jaci.2018.03.019

Solitary chemosensory cells are a primary epithelial source of IL-25 in patients with chronic rhinosinusitis with nasal polyps

Background: IL‐25 can function as an early signal for the respiratory type 2 response characteristic of allergic asthma and chronic rhinosinusitis with nasal polyps (CRSwNP). In the mouse gut, tuft cells are the epithelial source of IL‐25. However, the source of human airway epithelial IL‐25 has …