The DOI matches its Crossref record; 6 of the 6 references it cites were found in a registry or an index.
Itch: From mechanism to (novel) therapeutic approaches
Abstract
&NA; Itch is a common sensory experience that is prevalent in patients with inflammatory skin diseases, as well as in those with systemic and neuropathic conditions. In patients with these conditions, itch is often severe and significantly affects quality of life. Itch is encoded by 2 major neuronal pathways: histaminergic (in acute itch) and nonhistaminergic (in chronic itch). In the majority of cases, crosstalk existing between keratinocytes, the immune system, and nonhistaminergic sensory nerves is responsible for the pathophysiology of chronic itch. This review provides an overview of the current understanding of the molecular, neural, and immune mechanisms of itch: beginning in the skin, proceeding to the spinal cord, and eventually ascending to the brain, where itch is processed. A growing understanding of the mechanisms of chronic itch is expanding, as is our pipeline of more targeted topical and systemic therapies. Our therapeutic armamentarium for treating chronic itch has expanded in the last 5 years, with developments of topical and systemic treatments targeting the neural and immune systems.
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Noda, S., Suárez-Fariñas, M., Ungar, B., Kim, S. J., de Guzman Strong, C., Xu, H., Peng, X., Estrada, Y. D., Nakajima, S., Honda, T., et al. (2015) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2015.08.015 · Cited by 657
Prostaglandin E2-induced inflammation: Relevance of prostaglandin E receptors
Kawahara, K., Hohjoh, H., Inazumi, T., Tsuchiya, S., & Sugimoto, Y. (2015) · Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids · doi:10.1016/j.bbalip.2014.07.008 · Cited by 488
Kremer, A. E., van Dijk, R., Leckie, P., Schaap, F. G., Kuiper, E. M. M., Mettang, T., Reiners, K. S., Raap, U., van Buuren, H. R., van Erpecum, K. J., et al. (2012) · Hepatology · doi:10.1002/hep.25748 · Cited by 291
Kabashima, K., Furue, M., Hanifin, J. M., Pulka, G., Wollenberg, A., Galus, R., Etoh, T., Mihara, R., Nakano, M., & Ruzicka, T. (2018) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2018.03.018 · Cited by 248
Psychological interventions in the treatment of chronic itch
Schut, C., Mollanazar, N., Kupfer, J., Gieler, U., & Yosipovitch, G. (2016) · Acta Dermato-Venereologica · doi:10.2340/00015555-2177 · Cited by 119 · cited 2×
“Similar benefits can be seen with other techniques, such as acupuncture or progressive muscle relaxation.(175,177,178)”
BackgroundSelf-citationAprepitant: A Novel Antiemetic for Chemotherapy-Induced Nausea and Vomiting
Massaro, A. M., & Lenz, K. L. (2005) · Annals of Pharmacotherapy · doi:10.1345/aph.1e242 · Cited by 73 · cited 1×
“The NK-1 inhibitor aprepitant demonstrated efficacy in the treatment of prurigo nodularis, Sezary syndrome, and paraneoplastic itch; however, interactions with other medications restrict its use in some patients.(132,149) In a phase II clinical trial, serlopitant, another NK-1 inhibitor, significantly reduced pruritus…”
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Cited by
Hashimoto, T., Yokozeki, H., Karasuyama, H., & Satoh, T. (2023) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2022.11.009 · Cited by 96
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Metadata
- Authors
- Yosipovitch, G., Rosen, J. D., & Hashimoto, T.
- Venue
- Journal of Allergy and Clinical Immunology
- Publisher
- Elsevier BV
- Published
- 2018-11
- Volume
- 142
- Issue
- 5
- Pages
- 1375-1390
- ISSN
- 0091-6749 (ISSN-L)
- OpenAlex
- W2900062735
- Cited by
- 343
- References
- 6
- FWCI
- 25.87
- Type
- journal article
- Language
- en
- Open access
- closed
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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