Nonatopic eczema in elderly women: Effect of air pollution and genes
Open accessAbstract
Background Although many risk factors have been described for atopic eczema in children, little is known about the eczema phenotype in middle-aged or elderly adults.Objective We sought to examine the association between air pollution, atopy, and eczema in adulthood.Methods This analysis was based on 834 women from the Study on the influence of Air pollution on Lung Function, Inflammation and Ageing cohort in Germany. Incident symptoms of eczema after age 55 years and prevalent symptoms of eczema 12 months or less before investigation were assessed by means of questionnaire at the second follow-up (2007-2010). Total serum IgE levels were measured at baseline (1985-1994) and in 2007-2010. Exposure to air pollution was assessed by using land-use regression. Adjusted logistic regression models were applied to estimate the association between air pollution and incident and prevalent symptoms of eczema. Weighted genetic risk scores were used to investigate the effect of atopic eczema-related risk alleles on this association.Results Exposures to oxides of nitrogen (nitrogen dioxide and nitrogen oxides) and particulate matter (fine particulate matter with an aerodynamic diameter of ≤2.5 μm [PM 2.5] and particulate matter with an aerodynamic diameter of <10 μm) were significantly associated with increased odds of incident eczema (eg, with PM 2.5 per 4.7 μg/m 3; odds ratio, 1.45; 95% CI, 1.06-1.99). These associations were slightly more pronounced with nonatopic eczema (eg, with PM 2.5; odds ratio of 1.65 and 95% CI of 1.15-2.34 for participants without hay fever or increased IgE levels). Associations with air pollution were stronger in carriers of fewer risk alleles for atopic eczema.Conclusion Nonatopic eczema in the elderly is associated with traffic-related air pollutants, and this phenotype differs from genetically driven atopic eczema.
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PM2.5 is significantly associated with the development and exacerbation of skin diseases such as AD.
“Recent meta-analysis (21) and epidemiologic studies (22, 23) showed PM2.5 is significantly associated with the development and the exacerbation of skin diseases such as AD.”
From Particulate matter causes skin barrier dysfunction. (2021) · cites this paper as [22]
Table IV (Discussion; page unavailable) reports a significant association between PM2.5 and newly developed eczema symptoms after age 55, particularly after excluding atopic participants. It does not establish a significant association with exacerbation: the PM2.5 estimates for recent prevalent symptoms include the null, and the Discussion says no association was found for those symptoms. The study’s principal finding concerns nonatopic eczema in elderly women, not atopic dermatitis generally. (LLM, conf=0.88)
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References 52 · Cited by 58
Research works printed but not linked: 1
- H€ uls A, Kl€ umper C, MacIntyre EA, Brauer M, Mel en E, Bauer M, et al. Atopic dermatitis: interaction between genetic variants of GSTP1, TNF, TLR2 & TLR4 and air pollution in early life. Pediatr Allergy Immunol 2018;29: 596-605.
- Authors
- Hüls, A., Abramson, M. J., Sugiri, D., Fuks, K., Krämer, U., Krutmann, J., & Schikowski, T.
- Affiliations
- Leibniz Institute of Environmental Medicine (DE)
- Corresponding author
- Schikowski, Tamara
- Venue
- Journal of Allergy and Clinical Immunology
- Publisher
- Elsevier BV
- Published
- 2019-01
- Volume
- 143
- Issue
- 1
- Pages
- 378-385.e9
- ISSN
- 0091-6749 (ISSN-L)
- OpenAlex
- W2896801238
- Cited by
- 58
- References
- 52
- Citations by year
- 2026: 2 · 2025: 7 · 2024: 8 · 2023: 8 · 2022: 8 · 2021: 12 · 2020: 7 · 2019: 6
- FWCI
- 6.77
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Journal of Allergy and Clinical Immunology (publishedVersion)
- PubMed (publishedVersion)
- Monash University Research Portal (Monash University) (submittedVersion, other-oa)
- Funders
- Deutsche Forschungsgemeinschaft (HE-4510/2-1, KR 1938/3-1, LU 691/4-1, SCHI 1358/3-1)
- Ministry of the Environment of the State of North Rhine-Westphalia
- Federal Ministry of the Environment
- DGUV (VT 266.1)
- European Community's Seventh Framework Program (211250)
- Federal Ministry of Education and Research
- Heinrich-Heine University of Düsseldorf
- Topics
- Health Sciences › Medicine › Dermatology › Dermatology and Skin Diseases
- Physical Sciences › Environmental Science › Health, Toxicology and Mutagenesis › Air Quality and Health Impacts
- Health Sciences › Medicine › Physiology › Asthma and respiratory diseases
- Keywords
- atopic dermatitis, older women, air pollution, traffic-related air pollutants, nitrogen dioxide, nitrogen oxides, particulate matter, PM2.5, serum IgE, atopy, gene-environment interaction, risk alleles, risk score, allergic rhinitis, aging, land use regression, sailing
- MeSH terms
- Air Pollution, Alleles, Eczema, Environmental Exposure, Female, Follow-Up Studies, Gene Frequency, Humans, Middle Aged, Risk Factors, Incidence, Prevalence
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