The association between triglyceride-rich lipoproteins, circulating leukocytes, and low-grade inflammation: The Brazilian Longitudinal Study of Adult Health (ELSA-Brasil)
Abstract
Background Experimental studies have linked triglyceride-rich lipoproteins (TRLs) to inflammation, but the extent of this phenomenon in vivo has not been completely elucidated. Objective We investigated the association between TRL subparticles and inflammatory markers (circulating leukocytes, plasma high-sensitivity C-reactive protein [hs-CRP], and GlycA) in the general population. Methods This was a cross-sectional analysis of the Brazilian Longitudinal Study of Adult Health (ELSA-Brasil). TRLs (number of particles per unit volume) and GlycA were measured by nuclear magnetic resonance spectroscopy. The association between TRLs and inflammatory markers was determined by multiple linear regression models adjusted for demographic data, metabolic conditions, and lifestyle factors. Standardized regression coefficients (beta) with 95% confidence intervals are reported. Results The study population comprised 4,001 individuals (54% females, age 50 ± 9 years). TRLs, especially medium and large subparticles, were associated with GlycA (beta 0.202 [0.168, 0.235], p Conclusions There are different patterns of association between TRL subparticles and inflammatory markers. The findings support the hypothesis that TRLs (especially medium and larger subparticles) may induce a low-grade inflammatory environment that involves leukocyte activation and is captured by GlycA, but not hs-CRP.
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Systemically, TRLs and their remnants have been linked to markers of low-grade inflammation, including hs-CRP, circulating cytokines such as IL-6 and TNF-α, and immune cell activation.
“Systemically, TRLs and their remnants have been linked to markers of low-grade inflammation, including hs-CRP, circulating cytokines such as IL-6 and TNF-α, and immune cell activation [22–28].”
From Targeting triglycerides for cardiovascular risk reduction (2026) · cites this paper as [23]
Cites
Matthews, D. R., Hosker, J. P., Rudenski, A. S., Naylor, B. A., Treacher, D. F., & Turner, R. C. (1985) · Diabetologia · doi:10.1007/bf00280883 · Cited by 31,502 · see citing works
Joshi, P. H., Khokhar, A. A., Massaro, J. M., Lirette, S. T., Griswold, M. E., Martin, S. S., Blaha, M. J., Kulkarni, K. R., Correa, A., D'Agostino, R. B., et al. (2016) · Journal of the American Heart Association · doi:10.1161/jaha.115.002765 · Cited by 177 · see citing works
Self-citationLipolysis of triglyceride-rich lipoproteins, vascular inflammation, and atherosclerosis
Schwartz, E. A., & Reaven, P. D. (2012) · Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids · doi:10.1016/j.bbalip.2011.09.021 · Cited by 130 · see citing works
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Targeting triglycerides for cardiovascular risk reduction
Maiorca, C., Tramontano, D., Di Costanzo, A., & D’Erasmo, L. (2026) · Internal and Emergency Medicine · doi:10.1007/s11739-026-04383-1
- Authors
- Cesena, F. Y., Generoso, G., Santos, R. D., Pereira, A. C., Blaha, M. J., Jones, S. R., Toth, P. P., Lotufo, P. A., Bittencourt, M. S., & Benseñor, I. M.
- Affiliations
- Universidade de São Paulo (BR)
- Harvard University (US)
- Johns Hopkins Medicine (US)
- Johns Hopkins University (US)
- Corresponding author
- Cesena, Fernando Yue
- ORCID
- Venue
- Journal of Clinical Lipidology
- Publisher
- Elsevier BV
- Published
- 2023-03
- Volume
- 17
- Issue
- 2
- Pages
- 261-271
- ISSN
- 1876-4789 (ISSN-L)
- 1933-2874
- OpenAlex
- W4319601698
- Cited by
- 15
- References
- 3
- Citations by year
- 2026: 7 · 2025: 2 · 2024: 4 · 2023: 2
- FWCI
- 4.00
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Journal of clinical lipidology (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Department of Science and Technology, Ministry of Science and Technology, India
- Ministério da Ciência, Tecnologia e Inovação
- CNPq (303734/2018-3)
- Ministry of Science Technology and Innovation
- Ministry of Health
- Financiadora de Estudos e Projetos
- Topics
- Health Sciences › Medicine › Surgery › Lipoproteins and Cardiovascular Health
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Lipid metabolism and disorders
- Health Sciences › Medicine › Epidemiology › Adipokines, Inflammation, and Metabolic Diseases
- Keywords
- triglyceride-rich lipoproteins, low-grade inflammation, circulating leukocytes, glycated albumin, high-sensitivity C-reactive protein, neutrophils, lymphocytes, monocytes, ELSA-Brasil
- MeSH terms
- Adult, Brazil, C-Reactive Protein, Cross-Sectional Studies, Female, Humans, Inflammation, Leukocytes, Lipoproteins, Longitudinal Studies, Male, Middle Aged, Triglycerides
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