Effect of PCSK9 inhibition on plasma levels of small dense low density lipoprotein-cholesterol and 7-ketocholesterol

Mahmood, Tahir; Miles, Joshua R.; Minnier, Jessica; Tavori, Hagai; DeBarber, Andrea E.; Fazio, Sergio; Shapiro, Michael D.

doi:10.1016/j.jacl.2023.10.009

Effect of PCSK9 inhibition on plasma levels of small dense low density lipoprotein-cholesterol and 7-ketocholesterol

Background Oxidized forms of cholesterol (oxysterols) are implicated in atherogenesis and can accumulate in the body via direct absorption from food or through oxidative reactions of endogenous cholesterol, inducing the formation of LDL particles loaded with oxidized cholesterol. It remains unkno…