Possible connections among job stress, depressive symptoms, lipid modulation and antioxidants
Abstract
Background Oxidative/antioxidative status may be related to psychological stress or pathogenesis of depression. Subjects and methods Participants were selected from 381 female nurses working in a university hospital, and the Brief Job Stress Questionnaire was utilized to assess them. Nurses with high job stress (JS) (n = 18) and with low JS (n = 15) consented to participate in this study. Depressive symptoms were assessed by the Centre for Epidemiologic Studies Depression scale (CES-D). Cholesterols, lipid peroxidation (malondialdehyde, MDA) and antioxidants in the plasma were measured. Results High JS participants exhibited significantly higher CES-D scores (t = 3.34, p Limitations Sample numbers in each JS group were relatively small. Conclusions Psychological stress may reduce the plasma levels of LDL+VLDL accompanying an alpha-tocopherol decrease. There appeared to be a correlation between elevated MDA and depressive symptoms in low JS participants.
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Depression is associated with higher concentrations of low-density and very-low-density lipoprotein cholesterols.
“Some studies demonstrate associations of depression with higher concentrations of low-density and very-low-density lipoprotein cholesterols, 97”
From Psychological Health, Well-Being, and the Mind-Heart-Body Connection: A Scientific Statement From the American Heart Association (2021) · cites this paper as [97]
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References 37 · Cited by 119
- Authors
- Tsuboi, H., Tatsumi, A., Yamamoto, K., Kobayashi, F., Shimoi, K., & Kinae, N.
- Affiliations
- Hamamatsu University (JP)
- Corresponding author
- Tsuboi, Hirohito
- Venue
- Journal of Affective Disorders
- Publisher
- Elsevier BV
- Published
- 2006-03
- Volume
- 91
- Issue
- 1
- Pages
- 63-70
- ISSN
- 0165-0327 (ISSN-L)
- OpenAlex
- W2155108575
- Cited by
- 119
- References
- 37
- Citations by year
- 2026: 2 · 2025: 1 · 2024: 6 · 2023: 5 · 2022: 6 · 2021: 9 · 2020: 4 · 2019: 2 · 2018: 8 · 2017: 4 · 2016: 2 · 2015: 3 · 2014: 12 · 2013: 13 · 2012: 13
- FWCI
- 3.59
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Journal of Affective Disorders (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Biochemistry › Antioxidant Activity and Oxidative Stress
- Health Sciences › Health Professions › Occupational Therapy › Occupational Health and Burnout
- Health Sciences › Health Professions › General Health Professions › Workplace Health and Well-being
- Keywords
- occupational stress, depressive symptoms, lipid peroxidation, malondialdehyde, antioxidants, alpha-tocopherol, beta-carotene, total cholesterol, nurses, oxidative stress, lifestyle factors, plasma lipids, depression pathogenesis, Brief Job Stress Questionnaire
- MeSH terms
- Adult, Antioxidants, Cholesterol, Depressive Disorder, Female, Hospitals, University, Humans, Japan, Job Satisfaction, Cholesterol, LDL, Male, Malondialdehyde, Nurses, Surveys and Questionnaires, Risk Factors, Statistics as Topic, Stress, Psychological, Lipid Peroxidation, Cholesterol, VLDL, Workload, alpha-Tocopherol
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