Acute and long-term treatment outcome in depressed inpatients with vs. without anxious features: results of a one-year follow-up study
Abstract
Background Anxious depression (AD) is common in patients with unipolar depression. It remains unclear if they have a higher level of depressive symptoms, a higher risk of non-response, a poorer prognosis and a higher relapse rate compared to non-anxious depressed (non-AD) patients.Methods 168 patients took part in all three measurement points: (1) intake, (2) discharge and (3) follow-up. Patients fulfilled the criteria for anxious depression if they had a baseline score >7 on the anxiety/somatisation factor of the Hamilton Rating Scale for Depression (HRSD). Patients with AD and non-AD were compared regarding symptom reduction from intake to discharge as well as from discharge to one year after discharge. Primary outcome measure was the HRSD.Results The prevalence of AD was considerably high (81%). At intake, patients with AD had a significant higher score in the modified HRSD (M=20.67±4.12 vs. M=14.35±5.06). Both patient groups showed a significant and comparable intake-to-discharge symptom reduction in all inventories. Remission rates at discharge did not differ between AD and non-AD patients. At 1-year follow-up, AD patients showed a similar symptom severity compared to non-AD patients.Conclusion Symptoms of anxiety are common in depressive disorders are associated with higher depressive symptoms at the beginning of treatment. Acute and longer-term treatment outcome of AD patients was comparable to that of non-AD patients.Limitations Limitations of this study are the naturalistic design, treatment was not standardized and comorbid anxiety disorders were not assed using a structured interview.
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Patients with depression and comorbid anxiety disorders had a lower quality of life.
“Recently, multiple large-scale studies have reported that patients with depression and comorbid anxiety disorders had higher readmission rates [35], lower remission rates [41], greater depression severity [31 && ,41], higher suicidal risks [29,31 && ], a lower quality of life (QOL) [32,41], impaired social and occupational dysfunction [29], and an increased comorbidity of somatic conditions such”
From Patients with anxious depression: overview of prevalence, pathophysiology and impact on course and treatment outcome (2018) · cites this paper as [41]
Patients with depression and comorbid anxiety disorders had lower remission rates.
“Recently, multiple large-scale studies have reported that patients with depression and comorbid anxiety disorders had higher readmission rates [35], lower remission rates [41], greater depression severity [31 && ,41], higher suicidal risks [29,31 && ], a lower quality of life (QOL) [32,41], impaired social and occupational dysfunction [29], and an increased comorbidity of somatic conditions such”
From Patients with anxious depression: overview of prevalence, pathophysiology and impact on course and treatment outcome (2018) · cites this paper as [41]
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References 28 · Cited by 11
- Authors
- Köhler, S., Unger, T., Hoffmann, S., Steinacher, B., & Fydrich, T.
- Affiliations
- Charité – Universitätsmedizin Berlin (DE)
- Humboldt-Universität zu Berlin (DE)
- Vivantes Klinikum (DE)
- Corresponding author
- Unger, Theresa
- Venue
- Journal of Affective Disorders
- Publisher
- Elsevier BV
- Published
- 2013-09
- Volume
- 150
- Issue
- 3
- Pages
- 1055-1061
- ISSN
- 0165-0327 (ISSN-L)
- OpenAlex
- W2053325366
- Cited by
- 11
- References
- 28
- Citations by year
- 2021: 1 · 2020: 1 · 2017: 1 · 2016: 1 · 2015: 3 · 2014: 4
- FWCI
- 1.96
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Journal of Affective Disorders (publishedVersion)
- PubMed (publishedVersion)
- Research Publications (Maastricht University) (publishedVersion)
- Research Publications (Maastricht University) (submittedVersion)
- Topics
- Health Sciences › Medicine › Pharmacology › Treatment of Major Depression
- Social Sciences › Psychology › Experimental and Cognitive Psychology › Anxiety, Depression, Psychometrics, Treatment, Cognitive Processes
- Social Sciences › Psychology › Clinical Psychology › Psychotherapy Techniques and Applications
- Keywords
- anxious depression, major depressive disorder, hospitalized patients, treatment outcomes, remission, relapse, anxiety symptoms, symptom severity, long-term follow-up, comorbid anxiety disorders
- MeSH terms
- Adult, Aged, Anxiety Disorders, Depressive Disorder, Major, Major Depressive Disorder, Female, Follow-Up Studies, Humans, Inpatients, Long-Term Care, Male, Middle Aged, Personality Inventory, Recurrence, Comorbidity, Prevalence, Treatment Outcome
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