Do the dissociative side effects of ketamine mediate its antidepressant effects?
Luckenbaugh, David A., Niciu, Mark J., Ionescu, Dawn F., Nolan, Neal M., Richards, Erica M., Brutsche, Nancy E., Guevara, Sara, Zarate, Carlos A.·2014·Journal of Affective Disorders
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- Glutamate Pharmacological Models Relevant to Schizophrenia and PsychosisM. D. Rafter, Kevin C.F. Fone, Paula M. Moran · 2015 · Handbook of behavioral neuroscience
- Ketamine’s Mechanism of Rapid Antidepressant Activity: Evidence Gleaned from Clinical StudiesLynnette A. Averill, James W. Murrough, Chadi G. Abdallah · 2016 · Springer eBooks
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- High Baseline Plasma Anthranilic Acid Predicts Remission Upon Acute-Series Ketamine Infusion for Treatment-Resistant DepressionStephen Murata, Zachary Madaj, Colt D. Capan, Ryan D. Sheldon, Rif S. El‐Mallakh, Sagar V. Parikh, William Victor Bobo, Fernando S. Goes, Owen M. Wolkowitz, Jennifer L. Vande Voort et al. · 2025 · Biological Psychiatry Global Open Science
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- Ketamine: An Update for Its Use in Complex Regional Pain Syndrome and Major Depressive DisorderWilliam E. Bentley · 2015 · Clinical and Experimental Pharmacology
- Psychedelic PsychiatryDavid A. Bender, Joshua S. Siegel · 2024 · Elsevier eBooks
- General Anesthesia Occludes Ketamine's Antidepressant Response in a Rodent Model of Chronic StressDaniel Markman, Andrzej Z. Wasilczuk, Joseph Cichon · 2024 · Psychedelic Medicine
- Negative emotionality shapes the modulatory effects of ketamine and lamotrigine in subregions of the anterior cingulate cortexMatti Gärtner, Anne Weigand, Marvin Sören Meiering, David Weigner, Luisa Carstens, Christian Keicher, Rita Hertrampf, Christian F. Beckmann, Maarten Mennes, Andreas Wunder et al. · 2024 · Translational Psychiatry
- Oral Ketamine as a Treatment Option in Patients With Treatment Resistant Depression and Comorbid Arterial HypertensionL. Silberbauer, Lucie Bartova, Konstantinos Papageorgiou, Rupert R. Lanzenberger, Siegfried F. Kasper, Dietmar Winkler · 2020 · Journal of Clinical Psychopharmacology
- Cortical thickness of the posterior cingulate cortex is associated with the ketamine-induced altered sense of self: An ultra-high field MRI studyLena Vera Danyeli, Zümrüt Duygu Şen, Lejla Čolić, Nils Opel, Alexander Refisch, Nikolai Blekic, Tamar Macharadze, Moritz Kretzschmar, Matthias H. J. Munk, Christian Gaser B et al. · 2024 · Journal of Psychiatric Research
- A placebo-controlled crossover study of iloperidone augmentation for residual anger and irritability in major depressive disorderDawn Flosnik Ionescu, Maurizio Fava M. D, Daniel Ju Hyung Kim, Lee Baer, Richard Charles Shelton, Cristina Cusin · 2015 · Therapeutic Advances in Psychopharmacology
- Oral Prolonged-Release Ketamine for Treatment-Resistant DepressionMartin Walter, Christine zu Eulenburg, A. Damyanova, Karin Schmid, Isabel Schwienbacher, Evangelos Papanastasiou, K. Maiboe, Lars Arvastson, Caren Strote, Daniel Gehrlach et al. · 2026 · JAMA Network Open
- Ketamine for Depression: A Mixed-Methods StudyPhilip E. Wolfson · 2014 · International Journal of Transpersonal Studies
- The Modulation of Glutamatergic Signaling as a Potential Therapeutic Strategy for Major DepressionPatricio Molero, Enrique Aubá, María del Mar Unceta, Felipe Ortuño Sánchez Pedreño · 2022 · Springer eBooks
- The Link Between Dissociation and Religious/Spiritual ExperiencesEverton de Oliveira Maraldi · 2024 · Oxford University Press eBooks
- “Angry at the Wrong Thing:” Queering Ketamine Assisted Psychotherapy for Clients Experiencing Body Image and Eating DistressJessalyn Maguire · 2024 · Studies in Clinical Social Work Transforming Practice Education and Research
- Clinical relevance of cognitive dysfunction in major depressive disorderDanielle S. Cha · 2015 · Cambridge University Press eBooks
- From psychache to neuroplasticity: A unified rescue-repair model of Ketamine’s anti-suicidal actionDomany, Yoav, Solomon-Shashua, Aviv · 2026 · Neuroscience & Biobehavioral Reviews
- A computational model to characterize the time-course of response to rapid antidepressant therapiesA. Nunes, Selena Singh · 2024 · PLoS ONE
- Case Report: A possible association between significant dissociations after esketamine treatment and histrionic personality disorderVeronika Savica, Liene Sīle, Māris Taube · 2025 · Frontiers in Psychiatry
- Clinical Predictors of Antidepressant Effects of Ketamine and Esketamine in Treatment-Resistant Unipolar and Bipolar Depression: A Systematic ReviewOmer A. Syed, Valentyne Sobolenko, Sean M. Nestor, Muhammad Ishrat Husain, Nir Lipsman, Fahad Alam, Peter Giacobbe · 2026 · CNS Drugs
- IARS Emery Brown Award 2026: Anesthetics and Serotonergic Psychedelics May Promote Therapeutic Neuroplasticity by Destabilizing Pathological Neuronal CircuitryJoseph Cichon · 2026 · Anesthesia & Analgesia
- Antidepressant and Abuse Potential of KetamineHelge Hasselmann · 2016 · Elsevier eBooks
- Ketamine-Based Treatment of MDD: A Biologist’s PerspectiveShupeng Li, Yingli Zhang, Qiang Zhou · 2017 · Journal of Depression And Therapy
- A Pain Physician and Anesthesiologist’s Perspective on Ketamine for Treatment-Resistant DepressionLauren E. Gatewood, Andrew W. Gorlin, Christopher H. Bailey, George Barsoum, Steven B. Porter · 2023 · SN Comprehensive Clinical Medicine
- Ketamin und EsketaminCornelius Schüle, Gabi Koller, Uwe Herwig · 2024 · Nervenheilkunde
- Predictable Biomarkers for Rapid-Acting Antidepressant Response to KetamineYunfei Tan, Kenji Hashimoto · 2021 · Contemporary clinical neuroscience
- Ketamine and Other Glutamate Receptor Antagonists As Fast-ActinMu‐Hong Chen, Tung‐Ping Su, Shih‐Jen Tsai · 2022 · Neuromethods
- Ketamine in Psychiatric DisordersLena Vera Danyeli, Florian N. Götting, Zümrüt Duygu Şen, Meng Li, Martin Walter · 2022 · Springer eBooks
- Dissociative DisordersDamla E. Aksen, Steven Jay Lynn · 2025 · Cambridge University Press eBooks
- Dr Andrade RepliesChittaranjan Andrade · 2017 · The Journal of Clinical Psychiatry
- Is there a future for other glutamate receptor modulators in the pharmacotherapy of mood disorders?P. Šóš · 2016 · Evidence-Based Mental Health
- Ketamine Usage at Subanesthetic Doses and Psychoactive EffectsDaniel Flack, Elias Dakwar · 2016 · Elsevier eBooks
- Article Open AccessHolly Lawford‐Smith · 2015
- Ketamine: An important drug with a serious adverse effect - a reviewRoy Sebastian · 2018 · Journal of Psychology & Clinical Psychiatry
- Hur upplevda livsförändringar relaterar till enskilda, handledda psykedeliska sessionerDennis Ekeberg · 2014 · DiVA (Södertörn University)
- Evaluation of the antidepressant potential of dextromethorphanLinda Nguyen · 2015
- Ketamine in Psychiatric DisordersLena Vera Danyeli, Florian N. Götting, Zümrüt Duygu Şen, Meng Li, Martin Walter · 2021 · Springer eBooks
- (R)-Ketamine: A New Rapid-Acting AntidepressantKai Zhang, Kenji Hashimoto · 2021 · Contemporary clinical neuroscience
- Analysis of the self-ignition of a turbulent gas jet in a stream of oxidizing agentV. N. Strokin · 1972 · OSTI OAI (U.S. Department of Energy Office of Scientific and Technical Information)
- Faculty Opinions recommendation of Attenuation of antidepressant effects of ketamine by opioid receptor antagonism.René Hen · 2018 · Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature
- Schnell wirksame AntidepressivaZümrüt Duygu Şen, Lena Vera Danyeli, Martin Walter · 2022 · Springer eBooks
- KetamineJoshua D. Di Vincenzo, Joshua Daniel Rosenblat, Roger S. McIntyre · 2023
- Comparação de eficácia da cetamina intramuscular e da combinação escitalopram e aripiprazol no tratamento agudo e manutenção da depressão resistente: ensaio clínico duplo cego, controlado com placebo, randomizado e de grupos paralelosMarco Aurélio Cigognini · 2023
- Case report: Maintaining altered states of consciousness over repeated ketamine infusions may be key to facilitate long-lasting antidepressant effects: some initial lessons from a personalized-dosing single-case studySteffen Reissmann, Matthias Hartmann, Andreas Kist, Matthias E. Liechti, Kurt Stocker · 2023 · Frontiers in Psychiatry
- Exploring inner depthsJoost J. Breeksema · 2024
- Ketamine, Dissociation, and Depression: What Is “Special” About Ketamine? (Revisited)Mina Rizk, James W. Murrough · 2024 · The International Journal of Neuropsychopharmacology
- The parable of the TGA approval of esketamine (Spravato) in Australia: Part 2 - Submission for listing on the PBSWilliam Lugg · 2025 · Australasian Psychiatry
- Altered States of Consciousness Induced by Subanesthetic Ketamine Influence Differential Effects on Negative Affect Circuitry in Response to Emotional Stimulation in Nonclinical VolunteersLaura M. Hack, Xue Zhang, Leanne Maree Williams · 2025 · Neuromethods
- Ritual to Relief: Ethical Frontiers in Repurposing Psychoactive SubstancesEmma O’Leary, Seetal Dodd, Stephen M. Stahl · 2025 · Cambridge University Press eBooks
- Ketamine as a prophylactic agent against post-traumatic stress disorderJulia Peavey · 2023 · Journal of High School Science
- Sympathetic activation but not dissociation linked to ketamine’s sustained antidepressant effectVeronika Andrashko, T. Novak, Miloslav Kopeček, Anna Šuláková, V. Knop, Jiri Horacek · 2026 · Therapeutic Advances in Psychopharmacology
- A Blueprint for Implementing Ketamine-Assisted Psychotherapy in Palliative Care: Design, Process, and Treatment Patterns of a Real-World Clinical ProgramRobert K. Horowitz, William E. Rosa, Ali John Zarrabi, Marc T. Swogger · 2026 · Journal of Palliative Medicine
- Effectiveness and factors associated with esketamine response during the 4-week induction period for treatment-resistant depression: post-hoc analysis of the real-world ESKALE studyLudovic Samalin, Maud Rothärmel, Lila Mékaoui, Anne Sauvaget, Clotilde Wicart, E. Gaudre-Wattinne, Vanessa Cohignac, Andrés Malatesta, Julien Dupin · 2026 · Journal of Psychiatric Research
- Esketamine hydrochloride in the management of moderate‐to‐severe depressive symptoms in patients undergoing multiple wound repair surgeries: A multi‐centre randomized, double‐blind, placebo‐controlled trialXiaomeng Yu, Tianqi Shen, Ting Zhang, Rui Bao, Ziyi Guo, Zirui Feng, Li Tong, Xiaoying Zhang, Mingzi Ran, Guanyong Sun et al. · 2026 · Clinical and Translational Medicine
- Ketamine-induced changes in accumbal glutamate and their association with altered states of consciousnessLadina P Gubser, Anna Trippel, Niklaus Zoelch, Etna Engeli, Marcus Herdener · 2026 · Brain Research Bulletin
- Distinct Roles of Therapeutic Expectations and Dissociative Symptoms in Antidepressant Response During Ketamine Treatment in Routine CareWillys Cantenys, Zeynep Yoldas, Luc Masset, Alix Romier, Leonie Samion, Marion Imbault, Thai-Moc Tram Tran, Flávia M. Garcia, Samar Soltani, Martina Marradi et al. · 2026 · medRxiv
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- Dissociation and antidepressant response to subcutaneous esketamine: A clinical studyKaike Thiê da Costa Gonçalves, Vagner Deuel de Oliveira Tavares, Fernanda Palhano-Fontes, Patrícia Cavalcanti-Ribeiro, Victor Rocha Nóbrega de Almeida, David Cavalcante Barbosa, Tatiane Uetti Gomes Fernandes, Eduardo Igor Torquato Cardoso, Nicole Bezerra de Medeiros Lima, Aldielyson Jorge Cavalcante de Brito et al. · 2026 · Journal of Psychiatric Research
- A crucial cautionary note on frequently incorrect dose equivalence between ketamine and esketamineRodolfo Furlan Damiano, Gustavo C. Medeiros, João Quevedo · 2026 · Molecular Psychiatry
- Ketamine‐Assisted Psychotherapy as an Approach to Psychedelic HealingPhil Wolfson · 2026 · Wiley eBooks
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