The Effects of Lisdexamfetamine Dimesylate on Driving Behaviors in Young Adults With ADHD Assessed With the Manchester Driving Behavior Questionnaire
Abstract
Purpose Young adults with ADHD have been shown to be at increased risk for impairment in driving behaviors. Although stimulant medications have proven efficacy in reducing ADHD symptomatology, there is limited knowledge as to their effects on driving behavior. The focus of this report is on assessing the impact of lisdexamfetamine dimesylate (LDX) on driving behaviors in young adults with ADHD using a validated driving behavior questionnaire. Methods This assessment was carried out in the context of a randomized, double-blind, 6-week, placebo-controlled, parallel-design study of LDX versus placebo. Subjects were 61 outpatients of both sexes, 18-26 years of age, who met Diagnostic and Statistical Manual of Mental Disorders, fourth edition, criteria for ADHD. Subjects were randomized to receive LDX or placebo for 6 weeks. Driving behavior was assessed at baseline and at the end of treatment using a U.S. version of the Manchester Driving Behavior Questionnaire (DBQ). Results Highly significant improvements were documented on LDX, over placebo, in driving behaviors assessed through the DBQ in measures of driving errors, driving lapses, and a trend toward fewer driving violations. There were no meaningful associations between these DBQ results and previously documented changes in a laboratory driving simulation paradigm or with improvement in symptoms of ADHD assessed through the ADHD rating scale. Conclusions LDX treatment was associated with significant improvements in self-repo…
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In Babinski et al task 1 (neutral discussion), parents on LDX displayed a lower command to verbalization ratio, statistically significant (P = .04), associated with a large decrease in commands and moderate increases in verbalizations and responsiveness, although the latter were not significant.
“Task 1 was neutral discussion between parent and child, and parents on LDX displayed a lower command to verbalization ratio, which was statistically significant (P = .04), and associated with a large decrease in the number of commands, and moderate increases in verbalizations and responsiveness, although the latter were not significant.”
From Review of Lisdexamfetamine Dimesylate in Adults With Attention-Deficit/Hyperactivity Disorder (2017) · cites this paper as [43]
In Babinski et al, a 3-week open-label dose-optimization trial, LDX improved some aspects of parenting behaviors during 3 parent-child interaction tasks.
“In this 3-week open-label, dose-optimization trial, LDX was noted to improve some aspects of parenting behaviors during 3 parent-child interaction tasks.”
From Review of Lisdexamfetamine Dimesylate in Adults With Attention-Deficit/Hyperactivity Disorder (2017) · cites this paper as [43]
In Babinski et al, LDX was associated with a large increase in verbalizations and moderate decrease in ratio of commands to verbalizations as well as an increase in total commands with little change in verbalizations, resulting in an increase in the ratio of commands to total verbalizations.
“Lisdexamfetamine dimesylate was associated with a large increase in verbalizations and moderate decrease in ratio of commands to verbalizations as well as an increase in total commands with little change in verbalizations, resulting in an increase in the ratio of commands to total verbalizations.”
From Review of Lisdexamfetamine Dimesylate in Adults With Attention-Deficit/Hyperactivity Disorder (2017) · cites this paper as [43]
In Babinski et al, statistically significant effects were noted during tasks 2 and 3, associated with problem discussion and homework assignment, respectively.
“Statically significant effects were noted during tasks 2 and 3, associated with problem discussion and homework assignment, respectively.”
From Review of Lisdexamfetamine Dimesylate in Adults With Attention-Deficit/Hyperactivity Disorder (2017) · cites this paper as [43]
Some randomized controlled trials of lisdexamfetamine demonstrated efficacy and tolerability compared with placebo in adult ADHD but had limited sample size.
“Although some randomized controlled trials (RCTs) of LDX demonstrated its efficacy and tolerability, compared with placebo, in the treatment of adult ADHD,16,18–21 they had a limited sample size.”
From Exploratory meta-analysis on lisdexamfetamine versus placebo in adult ADHD (2014) · cites this paper as [19]
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References 34 · Cited by 24
- Authors
- Biederman, J., Fried, R., Hammerness, P., Surman, C., Mehler, B., Petty, C. R., Faraone, S. V., Miller, C., Bourgeois, M., Meller, B., Godfrey, K. M., Baer, L., & Reimer, B.
- Affiliations
- Harvard University (US)
- New England University Transportation Center (US)
- Massachusetts General Hospital (US)
- SUNY Upstate Medical University (US)
- ORCID
- Venue
- Journal of Adolescent Health
- Publisher
- Elsevier BV
- Published
- 2012-12
- Volume
- 51
- Issue
- 6
- Pages
- 601-607
- ISSN
- 1054-139X (ISSN-L)
- OpenAlex
- W2029010975
- Cited by
- 24
- References
- 34
- Citations by year
- 2026: 1 · 2024: 2 · 2023: 2 · 2022: 2 · 2021: 1 · 2020: 2 · 2018: 1 · 2017: 3 · 2016: 2 · 2015: 2 · 2014: 4 · 2013: 1 · 2012: 1
- FWCI
- 1.82
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Journal of Adolescent Health (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Shire
- Janssen Pharmaceuticals
- Topics
- Health Sciences › Medicine › Psychiatry and Mental health › Attention Deficit Hyperactivity Disorder
- Physical Sciences › Engineering › Safety, Risk, Reliability and Quality › Traffic and Road Safety
- Health Sciences › Medicine › Epidemiology › Substance Abuse Treatment and Outcomes
- Keywords
- lisdexamfetamine dimesylate, attention deficit hyperactivity disorder, driver behavior, young adults, stimulant medication, driving errors, traffic offenses, driving safety, ADHD symptom improvement
- MeSH terms
- Lisdexamfetamine Dimesylate, Adolescent, Adult, Central Nervous System Stimulants, Attention, Attention Deficit Disorder with Hyperactivity, Automobile Driving, Computer Simulation, Dextroamphetamine, Female, Humans, Male, Massachusetts, Psychomotor Performance, Surveys and Questionnaires, Young Adult
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