β-Amyloid, APOE and BDNF Genotype, and Depressive and Anxiety Symptoms in Cognitively Normal Older Women and Men
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Objective To examine how β-amyloid (Aβ), APOE and BDNF genotypes, and cortisol relate to depressive and anxiety symptoms in cognitively normal older women and men. Methods Cross-sectional data were analyzed from 423 older adults from the Australian Imaging Biomarkers and Lifestyle study. Analyses of covariance evaluated associations between Aβ, APOE and BDNF genotype, and cortisol in relation to severity of depressive and anxiety symptoms. Results Among Aβ+ older adults, APOE ε4 carriage was associated with greater severity of anxiety symptoms (d = 0.55); and in the full sample, APOE ε4 carriage was linked to greater severity of depressive (d = 0.26) and anxiety (d = 0.21) symptoms. Among Aβ+ women, ε4 carriers reported greater anxiety symptoms than non-ε4 carriers (d = 0.83), and female BDNF rs6265 Val66 Met allele carriers reported greater depressive symptoms (d = 0.29). Conclusion Sex moderated the relationship between Aβ, APOE genotype, and BDNF genotype in predicting severity of anxiety and depressive symptoms in cognitively normal older adults.
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The APOE ε4 allele is associated with severer depressive symptoms.
“and is associated with severer depressive symptoms [7]”
From APOE4 genotype exacerbates the depression-like behavior of mice during aging through ATP decline (2021) · cites this paper as [7]
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APOE4 genotype exacerbates the depression-like behavior of mice during aging through ATP decline
Fang, W., Xiao, N., Zeng, G., Bi, D., Dai, X., Mi, X., Ye, Q., Chen, X., & Zhang, J. (2021) · Translational Psychiatry · doi:10.1038/s41398-021-01631-0 · Cited by 42 · see citing works
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- Authors
- Holmes, S. E., Esterlis, I., Mazure, C. M., Lim, Y. Y., Ames, D., Rainey-Smith, S., Martins, R. N., Salvado, O., Dore, V., Villemagne, V. L., Rowe, C. C., Laws, S. M., Masters, C. L., Maruff, P., & Pietrzak, R. H.
- Affiliations
- Yale University (US)
- The University of Melbourne (AU)
- Edith Cowan University (AU)
- Commonwealth Scientific and Industrial Research Organisation (AU)
- Austin Hospital (AU)
- United States Department of Veterans Affairs (US)
- Corresponding author
- Holmes, Sophie E.
- ORCID
- Venue
- The American Journal of Geriatric Psychiatry
- Publisher
- Elsevier BV
- Published
- 2016-12
- Volume
- 24
- Issue
- 12
- Pages
- 1191-1195
- ISSN
- 1064-7481 (ISSN-L)
- OpenAlex
- W2514914570
- Cited by
- 40
- References
- 0
- Citations by year
- 2026: 5 · 2025: 4 · 2024: 8 · 2023: 3 · 2022: 1 · 2021: 5 · 2020: 3 · 2019: 4 · 2018: 3 · 2017: 4
- FWCI
- 2.80
- Type
- journal article
- Language
- en
- Open access
- green
- ro.ecu.edu.au
- Locations
- American Journal of Geriatric Psychiatry (publishedVersion)
- PubMed (publishedVersion)
- Murdoch University Research Portal (submittedVersion)
- Australasian Journal of Paramedicine (submittedVersion)
- eSpace (Curtin University) (submittedVersion)
- Funders
- National Health and Medical Research Council Australia (APP1009292)
- Science and Industry Endowment Fund
- Cooperative Research Centre for Mental Health
- National Institutes of Health (5R01MH104459, 1K01MH092681)
- U.S. Department of Veterans Affairs National Center for Posttraumatic Stress Disorder
- Topics
- Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
- Health Sciences › Medicine › Physiology › Alzheimer's disease research and treatments
- Health Sciences › Medicine › Neurology › Parkinson's Disease Mechanisms and Treatments
- Keywords
- amyloid-beta, APOE ε4, BDNF Val66Met polymorphism, genetic risk factors, depressive symptoms, anxiety symptoms, cortisol, sex differences, older adults, cognitively normal, Alzheimer's disease risk
- MeSH terms
- Aged, Aged, 80 and over, Anxiety, Apolipoproteins E, Cross-Sectional Studies, Depression, Female, Genetic Markers, Humans, Male, Middle Aged, Psychiatric Status Rating Scales, Amyloid beta-Peptides, Brain-Derived Neurotrophic Factor, Genetic Association Studies
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