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Cited by 149Treatment of Major DepressionElectroconvulsive Therapy StudiesTranscranial Magnetic Stimulation Studies

The DOI matches its Crossref record; 29 of the 29 references it cites were found in a registry or an index.

Pilot Randomized Controlled Trial of Titrated Subcutaneous Ketamine in Older Patients with Treatment-Resistant Depression

George, Duncan, Gálvez, Verònica, Martin, Donel, Kumar, Divya, Leyden, John, Hadzi-Pavlovic, Dusan, Harper, Simon, Brodaty, Henry, Glue, Paul, Taylor, Rohan, Mitchell, Philip B., Loo, Colleen K.·2017·The American Journal of Geriatric Psychiatry
DOI 10.1016/j.jagp.2017.06.007
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Abstract

Objective To assess the efficacy and safety of subcutaneous ketamine for geriatric treatment-resistant depression. Secondary aims were to examine if repeated treatments were safe and more effective in inducing or prolonging remission than a single treatment. Methods In this double-blind, controlled, multiple-crossover study with a 6-month follow-up (randomized controlled trial [RCT] phase), 16 participants (≥60 years) with treatment-resistant depression who relapsed after remission or did not remit in the RCT were administered an open-label phase. Up to five subcutaneous doses of ketamine (0.1, 0.2, 0.3, 0.4, and 0.5 mg/kg) were administered in separate sessions (≥1 week apart), with one active control (midazolam) randomly inserted (RCT phase). Twelve ketamine treatments were given in the open-label phase. Mood, hemodynamic, and psychotomimetic outcomes were assessed by blinded raters. Remitters in each phase were followed for 6 months. Results Seven of 14 RCT-phase completers remitted with ketamine treatment. Five remitted at doses below 0.5 mg/kg. Doses ≥ 0.2 mg/kg were significantly more effective than midazolam. Ketamine was well tolerated. Repeated treatments resulted in higher likelihood of remission or longer time to relapse. Conclusion Results provide preliminary evidence for the efficacy and safety of ketamine in treating elderly depressed. Dose titration is recommended for optimizing antidepressant and safety outcomes on an individual basis. Subcutaneous injection i…

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Metadata

Authors
George, D., Gálvez, V., Martin, D., Kumar, D., Leyden, J., Hadzi-Pavlovic, D., Harper, S., Brodaty, H., Glue, P., Taylor, R., Mitchell, P. B., & Loo, C. K.
Affiliations
  • Black Dog Institute (AU)
  • UNSW Sydney (AU)
  • Royal North Shore Hospital (AU)
  • Wesley Hospital (AU)
  • University of Otago (NZ)
Corresponding author
Loo, Colleen K.
ORCID
Venue
The American Journal of Geriatric Psychiatry
Publisher
Elsevier BV
Published
2017-11
Volume
25
Issue
11
Pages
1199-1209
ISSN
1064-7481 (ISSN-L)
DOI
10.1016/j.jagp.2017.06.007
OpenAlex
W2625860417
Cited by
149
References
29
Citations by year
2026: 10 · 2025: 17 · 2024: 37 · 2023: 13 · 2022: 17 · 2021: 21 · 2020: 16 · 2019: 4 · 2018: 10 · 2017: 4
FWCI
6.51
Type
journal article
Language
en
Open access
closed
Licence
www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations
  • American Journal of Geriatric Psychiatry (publishedVersion)
  • PubMed (publishedVersion)
Funders
  • NSW Institute of Psychiatry
  • University of Barcelona
  • NARSAD
Topics
  • Health Sciences › Medicine › Pharmacology (medical) › Treatment of Major Depression
  • Health Sciences › Medicine › Psychiatry and Mental health › Electroconvulsive Therapy Studies
  • Life Sciences › Neuroscience › Neurology › Transcranial Magnetic Stimulation Studies
Keywords
subcutaneous ketamine, treatment-resistant depression, geriatric depression, older adults, dose titration, remission, relapse, psychotomimetic effects, antidepressant efficacy, drug safety
MeSH terms
Aged, Double-Blind Method, Drug Administration Schedule, Female, Follow-Up Studies, Humans, Hypnotics and Sedatives, Injections, Subcutaneous, Ketamine, Male, Midazolam, Middle Aged, Pilot Projects, Remission Induction, Outcome Assessment, Health Care, Cross-Over Studies, Excitatory Amino Acid Antagonists, Depressive Disorder, Treatment-Resistant

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