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Cited by 24Alzheimer's disease research and treatmentsParkinson's Disease Mechanisms and TreatmentsDementia and Cognitive Impairment Research

High apolipoprotein E in cerebrospinal fluid of patients with Lewy body disorders is associated with dementia

Vijayaraghavan, Swetha, Maetzler, Walter, Reimold, Matthias, Lithner, Christina Unger, Liepelt‐Scarfone, Inga, Berg, Daniela, Darreh‐Shori, Taher·2014·Alzheimer's & Dementia
DOI 10.1016/j.jalz.2013.03.010
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Abstract

Apolipoprotein E ε4 allele (APOE ε4) increases the apolipoprotein E (apoE) protein levels in Alzheimer's disease (AD) cerebrospinal fluid (CSF). Thus, we hypothesized that apoE levels were also associated with the APOE genotype, and amyloid‐β (Aβ)‐associated clinical, functional, and imaging parameters in patients with Lewy body‐associated disorders (LBD). Indeed, similar to AD, patients with LBD displayed high CSF apoE levels (greatest in patients with dementia with LBD), and this was linked to APOE ε4. High CSF apoE protein correlated positively with CSF soluble amyloid precursor protein, total tau, and cortical and striatal Pittsburgh compound B retention; and correlated negatively with CSF Aβ 42, cognitive tests scores, and glucose uptake ratio in the temporal and parietal cortices. APOE ε4‐triggered accumulation of apoE in CSF is related to Aβ‐associated clinical and functional imaging parameters in LBD. Accordingly, therapeutic strategies aimed at reducing apoE levels in the brain should be explored not only in AD but also in LBD, particularly when accompanied with dementia.

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Crossref · 10.1016/j.jalz.2013.03.010

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  • Human studies of cerebrospinal fluid with various Alzheimer disease-related outcomes are conflicting, including differences in APOE genotype stratified analyses.

    “Human studies of cerebrospinal fluid with various Alzheimer diseaseerelated outcomes are conflicting, including differences in the APOE genotype stratified analyses [105,106].”

    From Plasma levels of apolipoprotein E, APOE genotype and risk of dementia and ischemic heart disease: A review (2016) · cites this paper as [106]

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Authors
Vijayaraghavan, S., Maetzler, W., Reimold, M., Lithner, C. U., Liepelt‐Scarfone, I., Berg, D., & Darreh‐Shori, T.
Affiliations
  • Karolinska Institutet (SE)
  • German Center for Neurodegenerative Diseases (DE)
  • University of Tübingen (DE)
Corresponding author
Darreh‐Shori, Taher
ORCID
Venue
Alzheimer's & Dementia
Publisher
Wiley
Published
2013-08-26
Volume
10
Issue
5
Pages
530
ISSN
  • 1552-5260 (ISSN-L)
  • 1552-5279
DOI
10.1016/j.jalz.2013.03.010
OpenAlex
W2082564633
Cited by
24
References
6
Citations by year
2025: 1 · 2024: 6 · 2020: 1 · 2019: 3 · 2017: 3 · 2016: 3 · 2015: 3 · 2014: 3 · 2013: 1
FWCI
2.32
Type
journal article
Language
en
Open access
closed
Licence
onlinelibrary.wiley.com/termsAndConditions#vor (vor)
Locations
  • Alzheimer s & Dementia (publishedVersion)
  • PubMed (publishedVersion)
  • DZNE Pub (submittedVersion)
Funders
  • American Liver Foundation
  • Stockholms Läns Landsting
  • Karolinska Institutet
  • Loo och Hans Ostermans Stiftelse för Medicinsk Forskning
  • Stiftelsen Olle Engkvist Byggmästare
  • Stiftelsen för Gamla Tjänarinnor
  • Gun och Bertil Stohnes Stiftelse
  • Åke Wiberg Stiftelse
  • Stiftelsen Ragnhild och Einar Lundströms Minne
Topics
  • Health Sciences › Medicine › Physiology › Alzheimer's disease research and treatments
  • Health Sciences › Medicine › Neurology › Parkinson's Disease Mechanisms and Treatments
  • Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
Keywords
apolipoprotein E, APOE ε4
MeSH terms
Aged, Aged, 80 and over, Aniline Compounds, Apolipoproteins E, Brain, Carbon Radioisotopes, Female, Glucose, Humans, Male, Middle Aged, Neuropsychological Tests, Peptide Fragments, Thiazoles, Cohort Studies, Biomarkers, Amyloid beta-Peptides, Amyloid beta-Protein Precursor, tau Proteins, Radiopharmaceuticals, Fluorodeoxyglucose F18, Lewy Body Disease, Positron-Emission Tomography

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