APOE interacts with age to modify rate of decline in cognitive and brain changes in Alzheimer's disease
Open accessAbstract
Objective: To determine (1) whether age‐standardized cognitive declines and brain morphometric change differ between Young‐Old patients with Alzheimer's disease (YOAD) and Very‐Old patients with Alzheimer's disease (VOAD), and (2) whether the apolipoprotein E ( APOE ) genotype modifies these neuropsychological and morphometric changes. Methods: Baseline and 12‐month follow‐up neuropsychological and morphometric measures were examined for healthy control subjects and patients with AD. The two AD groups were divided further into subgroups on the basis of the presence of at least one APOE ε4 allele. Results: The YOAD group showed more severe deficits and steeper declines in cognition than the VOAD group. Moreover, the presence of an APOE ε4 allele had a more deleterious effect on the YOAD group than the VOAD group on cognition and brain structure both cross‐sectionally and longitudinally. Conclusions: Results underscore the importance of integrating an individual's age and genetic susceptibility—and their interaction—when examining neuropsychological and neuroimaging changes in the early stages of Alzheimer's disease.
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
Cross-sectional studies have shown that SARS-CoV-2 infection is linked to an increased risk of cognitive impairment.
“several cross-sectional studies showing that SARS-CoV-2 infection is associated with an increase in risk of cognitive impairment”
From One-Year Trajectory of Cognitive Changes in Older Survivors of COVID-19 in Wuhan, China: A Longitudinal Cohort Study (2022) · cites this paper as [25]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
The citation lists haven’t been fetched yet
References 47 · Cited by 39
- Authors
- Chang, Y., Fennema‐Notestine, C., Holland, D., McEvoy, L. K., Stricker, N. H., Salmon, D. P., Dale, A. M., Bondi, M. W., & Initiative, A. D. N.
- Affiliations
- National Taiwan University (TW)
- University of California San Diego (US)
- Boston University (US)
- Corresponding author
- Bondi, Mark W.
- ORCID
- Venue
- Alzheimer's & Dementia
- Publisher
- Wiley
- Published
- 2013-07-29
- Volume
- 10
- Issue
- 3
- Pages
- 336-348
- ISSN
- 1552-5260 (ISSN-L)
- 1552-5279
- PMC
- PMC3815680
- OpenAlex
- W2070094826
- Cited by
- 39
- References
- 47
- Citations by year
- 2026: 1 · 2025: 1 · 2024: 1 · 2023: 2 · 2022: 2 · 2021: 3 · 2020: 2 · 2019: 3 · 2018: 3 · 2017: 4 · 2016: 8 · 2015: 5 · 2014: 4
- FWCI
- 4.03
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Alzheimer s & Dementia (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- eScholarship (California Digital Library) (submittedVersion)
- Funders
- National Institutes of Health (U01 AG024904, P30 AG010129, K01 AG030514)
- National Institute on Aging
- National Institute of Biomedical Imaging and Bioengineering
- Dana Foundation
- Topics
- Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
- Health Sciences › Medicine › Physiology › Alzheimer's disease research and treatments
- Social Sciences › Psychology › Experimental and Cognitive Psychology › Cognitive Abilities and Testing
- Keywords
- Alzheimer's disease, apolipoprotein E
- MeSH terms
- Age Factors, Aged, Aged, 80 and over, Alzheimer Disease, Brain, Cross-Sectional Studies, Female, Follow-Up Studies, Genotype, Humans, Longitudinal Studies, Magnetic Resonance Imaging, Male, Middle Aged, Neuropsychological Tests, Genetic Predisposition to Disease, Apolipoprotein E4
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
