A platform for discovery: The University of Pennsylvania Integrated Neurodegenerative Disease Biobank
Open accessAbstract
Neurodegenerative diseases (NDs) are defined by the accumulation of abnormal protein deposits in the central nervous system (CNS), and only neuropathological examination enables a definitive diagnosis. Brain banks and their associated scientific programs have shaped the actual knowledge of NDs, identifying and characterizing the CNS deposits that define new diseases, formulating staging schemes, and establishing correlations between neuropathological changes and clinical features. However, brain banks have evolved to accommodate the banking of biofluids as well as DNA and RNA samples. Moreover, the value of biobanks is greatly enhanced if they link all the multidimensional clinical and laboratory information of each case, which is accomplished, optimally, using systematic and standardized operating procedures, and in the framework of multidisciplinary teams with the support of a flexible and user‐friendly database system that facilitates the sharing of information of all the teams in the network. We describe a biobanking system that is a platform for discovery research at the Center for Neurodegenerative Disease Research at the University of Pennsylvania.
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Autopsy analyses classified the level of ADNC from "none" to "high" using an established scoring system when available.
“Autopsy analyses classified the level of ADNC from “none” to “high” using an established scoring system when available.”
From Automatic classification of AD pathology in FTD phenotypes using natural speech (2024) · cites this paper as [31]
Section 6 (page not provided) describes autopsy grading of Alzheimer-related pathology using Thal staging, a CERAD score, and a semiquantitative scale. It does not say that an overall ADNC level was classified from “none” to “high”; the scale it gives runs from “no changes” to “severe.” (LLM, conf=0.84)
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References 73 · Cited by 234
- Authors
- Toledo, J. B., Van Deerlin, V. M., Lee, E. B., Suh, E., Baek, Y., Robinson, J. L., Xie, S. X., McBride, J., Wood, E. M., Schuck, T., Irwin, D. J., Gross, R. G., Hurtig, H., McCluskey, L., Elman, L., Karlawish, J., Schellenberg, G., Chen‐Plotkin, A., Wolk, D., Grossman, M., Arnold, S. E., Shaw, L. M., Lee, V. M. ‐., & Trojanowski, J. Q.
- Affiliations
- Institute on Aging (US)
- Department of Pathology & Laboratory Medicine, Institute on Aging Center for Neurodegenerative Disease Research Philadelphia Pennsylvania USA
- University of Pennsylvania (US)
- Corresponding author
- Trojanowski, John Q.
- ORCID
- Venue
- Alzheimer's & Dementia
- Publisher
- Wiley
- Published
- 2013-08-26
- Volume
- 10
- Issue
- 4
- Pages
- 477
- ISSN
- 1552-5260 (ISSN-L)
- 1552-5279
- PMC
- PMC3933464
- OpenAlex
- W2123177715
- Cited by
- 234
- References
- 73
- Citations by year
- 2026: 17 · 2025: 20 · 2024: 23 · 2023: 18 · 2022: 32 · 2021: 25 · 2020: 27 · 2019: 11 · 2018: 21 · 2017: 13 · 2016: 6 · 2015: 10 · 2014: 10 · 2013: 1
- FWCI
- 6.27
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Alzheimer s & Dementia (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Institutes of Health (AG39510, AG033101, AG17586, AG10124, NS053488, NS44266, AG15116)
- Wyncote Foundation
- Fundación Alfonso Martín Escudero
- Topics
- Health Sciences › Medicine › Physiology › Alzheimer's disease research and treatments
- Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
- Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Ethics in Clinical Research
- Keywords
- neurodegenerative diseases
- MeSH terms
- Central Nervous System, Female, Genotype, Hospitals, University, Humans, Male, Pennsylvania, Databases, Factual, Amyloid beta-Peptides, tau Proteins, Biological Specimen Banks, Neurodegenerative Diseases
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