Sex biology contributions to vulnerability to Alzheimer's disease: a think tank convened by the Women's Alzheimer's Research Initiative
Open accessAbstract
More than 5 million Americans are living with Alzheimer's disease (AD) today, and nearly two-thirds of Americans with AD are women. This sex difference may be due to the higher longevity women generally experience; however, increasing evidence suggests that longevity alone is not a sufficient explanation and there may be other factors at play. The Alzheimer's Association convened an expert think tank to focus on the state of the science and level of evidence around gender and biological sex differences for AD, including the knowledge gaps and areas of science that need to be more fully addressed. This article summarizes the think tank discussion, moving forward a research agenda and funding program to better understand the biological underpinnings of sex- and gender-related disparities of risk for AD.
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AD is one of the most common diseases of aging and shows sex-specific incidence and progression.
“given that AD is one of the most common diseases of aging and shows sex-specific incidence and progression (113).”
From The Transcriptional Landscape of Microglial Genes in Aging and Neurodegenerative Disease (2019) · cites this paper as [113]
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References 125 · Cited by 262
Research works printed but not linked: 3
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- Authors
- Snyder, H. M., Asthana, S., Bain, L., Brinton, R., Craft, S., Dubal, D. B., Espeland, M. A., Gatz, M., Mielke, M. M., Raber, J., Rapp, P. R., Yaffe, K., & Carrillo, M. C.
- Affiliations
- Alzheimer's Association (US)
- University of Wisconsin–Madison (US)
- Independent Science Writer Philadelphia PA USA
- University of Southern California (US)
- Wake Forest University Health Sciences (US)
- University of California, San Francisco (US)
- Mayo Clinic (US)
- Oregon National Primate Research Center (US)
- National Institute on Aging (US)
- Division of Medical & Scientific Relations Alzheimer's Association Chicago IL USA
- Corresponding author
- Snyder, Heather M.
- ORCID
- Venue
- Alzheimer's & Dementia
- Publisher
- Wiley
- Published
- 2016-09-26
- Volume
- 12
- Issue
- 11
- Pages
- 1186-1196
- ISSN
- 1552-5260 (ISSN-L)
- 1552-5279
- PMC
- PMC10341380
- OpenAlex
- W2525025909
- Cited by
- 262
- References
- 125
- Citations by year
- 2026: 20 · 2025: 36 · 2024: 27 · 2023: 38 · 2022: 27 · 2021: 28 · 2020: 24 · 2019: 24 · 2018: 22 · 2017: 14 · 2016: 2
- FWCI
- 2.96
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Alzheimer s & Dementia (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- eScholarship (California Digital Library) (submittedVersion)
- Funders
- Mayo Clinic
- Alzheimer's Association
- National Institute on Aging (P50AG044170, P50AG033514)
- Topics
- Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
- Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Sex and Gender in Healthcare
- Health Sciences › Medicine › Physiology › Alzheimer's disease research and treatments
- Keywords
- Alzheimer's disease, sex differences
- MeSH terms
- Alzheimer Disease, Disease Susceptibility, Female, Humans, Risk Factors, Sex Characteristics, Sex Factors, Societies, Scientific
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