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Cited by 192Thyroid and Parathyroid SurgeryParathyroid Disorders and TreatmentsThyroid Disorders and Treatments

The DOI matches its Crossref record; 30 of the 30 references it cites were found in a registry or an index.

Early Prediction of Hypocalcemia after Thyroidectomy using Parathyroid Hormone: An Analysis of Pooled Individual Patient Data from Nine Observational Studies

Noordzij, Pieter J., Lee, Stephanie L., Bernet, Victor J., Payne, Richard J., Cohen, Seth M., McLeod, Ian K., Hier, Michael P., Black, Martin J., Kerr, Paul D., Richards, Melanie L., Lo, Chung Yau, Raffaelli, Marco, Bellantone, Rocco, Lombardi, Celestino P., Cohen, James I., Dietrich, Mary S.·2007·Journal of the American College of Surgeons
DOI 10.1016/j.jamcollsurg.2007.06.298
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Abstract

BACKGROUND: Monitoring for hypocalcemia after thyroidectomy, using only symptoms and serum calcium levels, can delay the discharge of patients who will remain normocalcemic and can delay the treatment of hypocalcemic patients. STUDY DESIGN: We conducted a systematic search for articles describing use of parathyroid hormone (PTH) assay, checked within hours of completing thyroidectomy, to predict postoperative symptomatic hypocalcemia. Studies were excluded if all patients were treated with postoperative calcium, or if early PTH values were used to alter management of the patient. Individual patient data (perioperative PTH and calcium levels, development of hypocalcemia) were obtained for 457 patients from the corresponding authors of 9 studies and pooled to yield the following results. RESULTS: PTH, checked at three time periods after removal of the thyroid gland (0 to 20 minutes, 1 to 2 hours, and 6 hours), was substantially lower in patients who became hypocalcemic compared with those who remained normocalcemic. The accuracy of PTH in determining hypocalcemia increased with time and was excellent when checked 1 to 6 hours postoperatively. A single PTH threshold (65% decrease compared with preoperative level), checked 6 hours after completing thyroidectomy, had a sensitivity of 96.4% and specificity of 91.4% in detecting postoperative hypocalcemia. CONCLUSIONS: PTH assay, when checked 1 to 6 hours after thyroidectomy, has excellent accuracy in determining which patients will become symptomatically hypocalcemic. Routine use of this assay should be considered because it may allow earlier discharge of the normocalcemic patient and earlier identification of patients requiring treatment of postthyroidectomy hypocalcemia.

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Crossref · 10.1016/j.jamcollsurg.2007.06.298

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Metadata

Authors
Noordzij, P. J., Lee, S. L., Bernet, V. J., Payne, R. J., Cohen, S. M., McLeod, I. K., Hier, M. P., Black, M. J., Kerr, P. D., Richards, M. L., Lo, C. Y., Raffaelli, M., Bellantone, R., Lombardi, C. P., Cohen, J. I., & Dietrich, M. S.
Affiliations
  • Boston University (US)
  • Walter Reed National Military Medical Center (US)
  • Jewish General Hospital (CA)
  • Duke University (US)
  • University of Manitoba (CA)
  • Mayo Clinic (US)
  • Queen Mary Hospital (CN)
  • Università Cattolica del Sacro Cuore (IT)
  • Oregon Health & Science University (US)
  • Vanderbilt University (US)
ORCID
Venue
Journal of the American College of Surgeons
Publisher
Ovid Technologies (Wolters Kluwer Health)
Published
2007-12
Volume
205
Issue
6
Pages
748-754
ISSN
1072-7515 (ISSN-L)
DOI
10.1016/j.jamcollsurg.2007.06.298
OpenAlex
W2043355472
Cited by
192
References
30
Citations by year
2026: 8 · 2025: 3 · 2024: 6 · 2023: 3 · 2022: 6 · 2021: 13 · 2020: 10 · 2019: 12 · 2018: 8 · 2017: 19 · 2016: 8 · 2015: 21 · 2014: 12 · 2013: 13 · 2012: 12
FWCI
7.96
Type
journal article
Language
en
Open access
closed
Licence
www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations
  • Journal of the American College of Surgeons (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Health Sciences › Medicine › Surgery › Thyroid and Parathyroid Surgery
  • Health Sciences › Medicine › Nephrology › Parathyroid Disorders and Treatments
  • Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Thyroid Disorders and Treatments
Keywords
postoperative hypocalcemia, thyroidectomy, parathyroid hormone assay, postoperative discharge, diagnostic accuracy, sensitivity and specificity
MeSH terms
Humans, Hypocalcemia, Parathyroid Hormone, Predictive Value of Tests, ROC Curve, Thyroidectomy, Time Factors

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