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The Impact of Prehabilitation on Postoperative Outcomes in Colorectal Cancer: A Meta-Analysis of Randomized Controlled Trials

Xun, Xiaodong, Wang, Renxian, Cheng, Qian, Gao, Pengji·2026·Journal of the American Medical Directors Association

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Research works printed but not linked: 23

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  2. van Vledder, 2012, Body composition and outcome in patients undergoing resection of colorectal liver metastases, Br J Surg, 99, 550, 10.1002/bjs.7823 · DOI
  3. Shanmugasundaram, 2025, Prehabilitation strategies: enhancing surgical resilience with a focus on nutritional optimization and multimodal interventions, Adv Nutr, 16
  4. Fulop, 2021, The effect of trimodal prehabilitation on the physical and psychological health of patients undergoing colorectal surgery: a randomised clinical trial, Anaesthesia, 76, 82, 10.1111/anae.15215 · DOI
  5. Hughes, 2019, Prehabilitation before major abdominal surgery: a systematic review and meta-analysis, World J Surg, 43, 1661, 10.1007/s00268-019-04950-y · DOI · Paper page
  6. Kottner, 2011, Guidelines for Reporting Reliability and Agreement Studies (GRRAS) were proposed, J Clin Epidemiol, 64, 96, 10.1016/j.jclinepi.2010.03.002 · DOI
  7. Sterne, 2019, RoB 2: a revised tool for assessing risk of bias in randomised trials, BMJ, 366
  8. Zou, 2007, One relative risk versus two odds ratios: implications for meta-analyses involving paired and unpaired binary data, Clin Trials, 4, 25, 10.1177/1740774506075667 · DOI
  9. Egger, 1997, Bias in meta-analysis detected by a simple, graphical test, BMJ, 315, 629, 10.1136/bmj.315.7109.629 · DOI · Paper page
  10. Begg, 1994, Operating characteristics of a rank correlation test for publication bias, Biometrics, 50, 1088, 10.2307/2533446 · DOI · Paper page
  11. Danielsson, 2025, Optimizing physical fitness before colorectal cancer surgery (CanOptiPhys): the effect of preoperative exercise on pre- and postoperative physical fitness in older people - a randomized controlled trial, J Prim Care Community Health, 16, 10.1177/21501319251346417 · DOI
  12. Ten Cate, 2024, Multimodal prehabilitation in elective oncological colorectal surgery enhances postoperative functional recovery: a secondary analysis of the prehab randomized clinical trial, Eur J Surg Oncol, 50, 10.1016/j.ejso.2024.108270 · DOI
  13. Pesce, 2024, A randomized controlled clinical trial on multimodal prehabilitation in colorectal cancer patients to improve functional capacity: preliminary results, Surg Endosc, 38, 7440, 10.1007/s00464-024-11198-8 · DOI
  14. Yang, 2024, Effect of prehabilitation exercises on postoperative frailty in patients undergoing laparoscopic colorectal cancer surgery, Front Oncol, 14
  15. Triguero-Canovas, 2023, Home-based prehabilitation improves physical conditions measured by ergospirometry and 6MWT in colorectal cancer patients: a randomized controlled pilot study, Support Care Cancer, 31, 673
  16. Carli, 2020, Effect of multimodal prehabilitation vs postoperative rehabilitation on 30-day postoperative complications for frail patients undergoing resection of colorectal cancer: a randomized clinical trial, JAMA Surg, 155, 233, 10.1001/jamasurg.2019.5474 · DOI · Paper page
  17. Karlsson, 2019, Feasibility of preoperative supervised home-based exercise in older adults undergoing colorectal cancer surgery - a randomized controlled design, PLoS One, 14, 10.1371/journal.pone.0219158 · DOI
  18. Bousquet-Dion, 2018, Evaluation of supervised multimodal prehabilitation programme in cancer patients undergoing colorectal resection: a randomized control trial, Acta Oncol, 57, 849, 10.1080/0284186X.2017.1423180 · DOI
  19. Gillis, 2016, Prehabilitation with whey protein supplementation on perioperative functional exercise capacity in patients undergoing colorectal resection for cancer: a pilot double-blinded randomized placebo-controlled trial, J Acad Nutr Diet, 116, 802, 10.1016/j.jand.2015.06.007 · DOI
  20. Schneider, 2020, Prehabilitation programs and ERAS protocols in gynecological oncology: a comprehensive review, Arch Gynecol Obstet, 301, 315, 10.1007/s00404-019-05321-7 · DOI
  21. Wijma, 2023, Personalized multimodal prehabilitation reduces cardiopulmonary complications after pancreatoduodenectomy: results of a propensity score matching analysis, HPB (Oxford), 25, 1429, 10.1016/j.hpb.2023.07.899 · DOI
  22. Kash, 2014, The perioperative surgical home (PSH): a comprehensive review of US and non-US studies shows predominantly positive quality and cost outcomes, Milbank Q, 92, 796, 10.1111/1468-0009.12093 · DOI
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Metadata

Authors
Xun, X., Wang, R., Cheng, Q., & Gao, P.
Venue
Journal of the American Medical Directors Association
Publisher
Elsevier BV
Published
2026-04
Volume
27
Issue
4
Pages
106132
ISSN
1525-8610
Cited by
5
References
4
Language
en
Funders
Beijing Municipal Health Commission

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CoChat. (2026). Citation check: The Impact of Prehabilitation on Postoperative Outcomes in Colorectal Cancer: A Meta-Analysis of Randomized Controlled Trials. https://app.cochat.ai/papers/10.1016/j.jamda.2026.106132
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Xun, X., Wang, R., Cheng, Q., & Gao, P. (2026). The Impact of Prehabilitation on Postoperative Outcomes in Colorectal Cancer: A Meta-Analysis of Randomized Controlled Trials. Journal of the American Medical Directors Association. https://doi.org/10.1016/j.jamda.2026.106132