Disentangling intolerance of uncertainty and threat appraisal in everyday situations
Open accessAbstract
Intolerance of Uncertainty is a transdiagnostic risk and maintenance factor in a range of anxiety disorders and major depressive disorder. However, the mechanism of action in the development and maintenance of anxiety disorders is poorly understood, with the relationship between the constructs of uncertainty and threat appraisal remaining unclear. Most research to date has investigated IU in situations that are explicitly or implicitly threatening (i.e. where they have a negative outcome), which makes it difficult to establish whether it is the uncertainty or the prospect of a negative outcome (or threat) that people find aversive. If the construct of IU is about uncertainty (and not threat), it should also be operating in situations where there are no negative outcomes possible. Participants (N = 224) completed a battery of online measures in tasks designed to evaluate level of situational uncertainty and perception of threat level. These tasks required responses to scenarios which displayed or implied varying levels of estimated threat. Regression analyses indicated that IU was related to perceiving threat and uncertainty in negative situations and positive situations, with the greatest contribution from uncertainty within the situations, supporting the conceptualisation of IU as a response to uncertainty that is largely independent of threat although may contribute to perceptions of threat.
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IU has been related to social anxiety, generalized anxiety disorder, panic disorder, agoraphobia and hypochondria, PTSD, and major depressive disorder.
“With regard to anxiety-related disorders per se, IU has been related to social anxiety, generalized anxiety disorder, panic disorder, agoraphobia and hypochondria, PTSD, and major depressive disorder. 5,18,19-21”
From Psychometric properties of the brazilian intolerance of uncertainty scale – short version (Ius-12) (2020) · cites this paper as [20]
Individuals with higher levels of intolerance of uncertainty perceive uncertain situations as more threatening and unsafe.
“A wealth of research has shown that individuals with higher levels of IU perceive uncertain situations as more threatening and unsafe (Cupid et al., 2021; Pepperdine et al., 2018)”
From Intolerance of uncertainty, paranoia, and prodromal symptoms: Comparisons between a schizophrenia spectrum disorder, anxiety disorder and non‐clinical sample. (2025) · cites this paper as Pepperdine et al., 2018
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References 44 · Cited by 84
- Authors
- Pepperdine, E., Lomax, C., & Freeston, M. H.
- Affiliations
- Cumbria Northumberland Tyne and Wear NHS Foundation Trust (GB)
- Newcastle University (GB)
- Corresponding author
- Lomax, C.
- ORCID
- Freeston, M.H.
- Venue
- Journal of Anxiety Disorders
- Publisher
- Elsevier BV
- Published
- 2018-06
- Volume
- 57
- Pages
- 31-38
- ISSN
- 0887-6185 (ISSN-L)
- OpenAlex
- W2795560020
- Cited by
- 84
- References
- 44
- Citations by year
- 2026: 22 · 2025: 18 · 2024: 10 · 2023: 5 · 2022: 12 · 2021: 5 · 2020: 7 · 2019: 3 · 2018: 1
- FWCI
- 5.24
- Type
- journal article
- Language
- en
- Open access
- green
- doi.org
- Licence
- Locations
- Journal of Anxiety Disorders (publishedVersion)
- PubMed (publishedVersion)
- Newcastle University ePrints (Newcastle Univesity)
- Topics
- Social Sciences › Psychology › Experimental and Cognitive Psychology › Anxiety, Depression, Psychometrics, Treatment, Cognitive Processes
- Social Sciences › Psychology › Clinical Psychology › Child and Adolescent Psychosocial and Emotional Development
- Social Sciences › Decision Sciences › General Decision Sciences › Decision-Making and Behavioral Economics
- Keywords
- intolerance of uncertainty, threat appraisal, situational uncertainty, threat perception, anxiety disorders, major depressive disorder, transdiagnostic risk factors, everyday situations
- MeSH terms
- Adolescent, Adult, Affect, Aged, Anxiety, Anxiety Disorders, Major Depressive Disorder, Female, Humans, Male, Middle Aged, Regression Analysis, Uncertainty, Young Adult
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