The DOI matches its Crossref record; 125 of the 125 references it cites were found in a registry or an index.
Gout: An old disease in new perspective – A review
Open accessAbstract
Gout is a picturesque presentation of uric acid disturbance. It is the most well understood and described type of arthritis. Its epidemiology is studied. New insights into the pathophysiology of hyperuricemia and gouty arthritis; acute and chronic allow for an even better understanding of the disease. The role of genetic predisposition is becoming more evident. The clinical picture of gout is divided into asymptomatic hyperuricemia, acute gouty arthritis, intercritical period, and chronic tophaceous gout. Diagnosis is based on laboratory and radiological features. The gold standard of diagnosis is identification of characteristic MSU crystals in the synovial fluid using polarized light microscopy. Imaging modalities include conventional radiography, ultrasonography, conventional CT, Dual-Energy CT, Magnetic Resonance Imaging, nuclear scintigraphy, and positron emission tomography. There is remarkable progress in the application of ultrasonography and Dual-Energy CT which is bound to influence the diagnosis, staging, follow-up, and clinical research in the field. Management of gout includes management of flares, chronic gout and prevention of flares, as well as management of comorbidities. Newer drugs in the pharmacological armamentarium are proving successful and supplement older ones. Other important points in its management include patient education, diet and life style changes, as well as cessation of hyperuricemic drugs.
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Cites
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Overlapping DRESS and Stevens-Johnson Syndrome: Case Report and Review of the Literature
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Self-citationFebuxostat Compared with Allopurinol in Patients with Hyperuricemia and Gout
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HLA-B*5801 allele as a genetic marker for severe cutaneous adverse reactions caused by allopurinol
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Global epidemiology of gout: prevalence, incidence and risk factors
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Low-Dose Colchicine for Secondary Prevention of Cardiovascular Disease
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Cited by
Inflammation in gout: mechanisms and therapeutic targets
So, A. K., & Martinon, F. (2017) · Nature Reviews Rheumatology · doi:10.1038/nrrheum.2017.155 · Cited by 608
From purines to purinergic signalling: molecular functions and human diseases
Huang, Z., Xie, N., Illes, P., Di Virgilio, F., Ulrich, H., Semyanov, A., Verkhratsky, A., Sperlagh, B., Yu, S.-G., Huang, C., et al. (2021) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-021-00553-z · Cited by 489
Atherosclerosis and Inflammation: Insights from the Theory of General Pathological Processes
Gusev, E., & Sarapultsev, A. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms24097910 · Cited by 312
Metadata
- Authors
- Ragab, G., Elshahaly, M., & Bardin, T.
- Venue
- Journal of Advanced Research
- Publisher
- Elsevier BV
- Published
- 2017-09
- Volume
- 8
- Issue
- 5
- Pages
- 495-511
- ISSN
- 2090-1224 (ISSN-L)
- 2090-1232
- OpenAlex
- W2613828117
- Cited by
- 599
- References
- 125
- FWCI
- 28.70
- Type
- journal article
- Language
- en
- Open access
- gold
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
