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Abstract 1092 Hepatic nonvesicular cholesterol transport is critical for systemic lipid homeostasis

Xiao, Xu, Kennelly, J.P., Tontonoz, Peter·2024·Journal of Biological Chemistry

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Integrity signals

Registry

Crossref · 10.1016/j.jbc.2024.106422

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Claims other papers make about this one

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  • Previous studies showed that in macrophages and hepatocytes Asters specifically recognize the accessible pool of plasma membrane cholesterol.

    “Previous studies showed that in macrophages (33) and hepatocytes (28) Asters specifically recognize the accessible pool of PM cholesterol (34, 35).”

    From Aster-dependent nonvesicular transport facilitates dietary cholesterol uptake (2023) · cites this paper as [28]

    The Abstract Body (page not given) says accessible plasma-membrane cholesterol engages the Aster pathway in the liver, supporting the hepatocyte connection. It does not establish that Asters specifically recognize that cholesterol pool. The macrophage finding is separately attributed to citation 33 in the citing sentence. (LLM, conf=0.80)

    Experimental — accuracy not yet measured
  • Aster-C is important for hepatic reverse cholesterol transport.

    “In mice, Aster-B is required for CE storage and corticosteroid synthesis in the adrenal cortex (25), while Aster-C is important for hepatic reverse cholesterol transport (28).”

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Metadata

Authors
Xiao, X., Kennelly, J. P., & Tontonoz, P.
Venue
Journal of Biological Chemistry
Publisher
Elsevier BV
Published
2024-03
Volume
300
Issue
3
Pages
106422
ISSN
0021-9258
Cited by
0
Language
en

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