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Cited by 44Knee injuries and reconstruction techniquesElasticity and Material ModelingTendon Structure and Treatment

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Microstructural properties and mechanics vary between bundles of the human anterior cruciate ligament during stress-relaxation

Castile, Ryan M., Skelley, Nathan W., Babaei, Behzad, Brophy, Robert H., Lake, Spencer P.·2016·Journal of Biomechanics
DOI 10.1016/j.jbiomech.2015.11.016
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Abstract

Previous studies have shown different elastic properties between the anteromedial (AM) and posterolateral (PL) bundles of the human anterior cruciate ligament (ACL). However, it is unknown if the two bundles of the ACL exhibit distinct time-dependent properties and microstructural organization, which have important implications for fully understanding the structure-function relationships of this oft-injured ligament. The goal of this study was to quantify the viscoelastic material properties and collagen fiber alignment of the AM and PL bundles in 16 human ACLs during stress-relaxation mechanical tests using the quasi-linear viscoelastic (QLV) model and a quantitative polarization imaging technique. We hypothesized that the AM and PL bundles would exhibit differences in the instantaneous mechanical and organizational properties (i.e., immediately following a step increase in strain), but similar time-dependent changes during stress-relaxation. Results showed that AM samples exhibited larger peak/equilibrium stresses and less stress-relaxation during a 300-s hold compared to PL samples. The AM bundle demonstrated stronger and more uniform collagen fiber alignment (i.e., higher degree of linear polarization (DoLP) values and less distributed angle of polarization (AoP) values) compared to the PL bundle, and larger changes in alignment strength during the hold. Results suggest that the AM bundle is the more "dominant" bundle, with significantly different mechanical and material properties in stress-relaxation. While more research is needed to better understand how these findings relate to the pathophysiology of ACL tears and can best guide treatment, the findings provide additional insight into the microstructural properties and biomechanics of the human ACL.

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Metadata

Authors
Castile, R. M., Skelley, N. W., Babaei, B., Brophy, R. H., & Lake, S. P.
Affiliations
Washington University in St. Louis (US)
Corresponding author
Lake, Spencer P.
ORCID
Venue
Journal of Biomechanics
Publisher
Elsevier BV
Published
2016-01
Volume
49
Issue
1
Pages
87-93
ISSN
0021-9290 (ISSN-L)
DOI
10.1016/j.jbiomech.2015.11.016
OpenAlex
W2283315735
Cited by
44
References
46
Citations by year
2025: 4 · 2024: 5 · 2023: 2 · 2022: 3 · 2021: 3 · 2020: 10 · 2019: 2 · 2018: 8 · 2017: 4 · 2016: 3
FWCI
5.05
Type
journal article
Language
en
Open access
closed
Licence
www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations
  • Journal of Biomechanics (publishedVersion)
  • PubMed (publishedVersion)
Funders
Musculoskeletal Transplant Foundation
Topics
  • Health Sciences › Medicine › Surgery › Knee injuries and reconstruction techniques
  • Physical Sciences › Engineering › Biomedical Engineering › Elasticity and Material Modeling
  • Health Sciences › Medicine › Orthopedics and Sports Medicine › Tendon Structure and Treatment
Keywords
anterior cruciate ligament, anteromedial bundle, posterolateral bundle, stress relaxation, viscoelasticity, collagen fiber alignment, quasi-linear viscoelastic model, polarization imaging, time-dependent mechanical properties, anterior cruciate ligament rupture
MeSH terms
Anterior Cruciate Ligament Injuries, Adult, Biomechanical Phenomena, Collagen, Elasticity, Female, Humans, Male, Middle Aged, Sprains and Strains, Stress, Physiological, Stress, Mechanical, Viscosity, Anterior Cruciate Ligament

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