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Cited by 82Cancer, Lipids, and MetabolismLipid metabolism and biosynthesisSphingolipid Metabolism and Signaling

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Molecular mechanisms of fatty acid synthase (FASN)-mediated resistance to anti-cancer treatments

Wu, Xi, Qin, Li, Fako, Valerie, Zhang, Jian-Ting·2014·Advances in Biological Regulation
DOI 10.1016/j.jbior.2013.09.004
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Abstract

Human FASN is the key enzyme required for de novo synthesis of fatty acids. Up-regulated FASN expression has been reported in various human cancers and was thought to contribute to poor prognosis and recurrence of these cancers. Studies using model cell lines have indicated the role of FASN in both intrinsic and acquired drug and radiation resistance. Recent studies suggest that FASN may play an important role in regulating gene expression such as pro-apoptotic proteins and cellular processes such as DNA repair pathways, which in turn contribute to resistance to drug and radiation-induced apoptosis. In this review, we will highlight our recent progress in understanding the mechanism of FASN-induced resistance.

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Research works printed but not linked: 48

  1. Alo, 2007, Immunohistochemical expression and prognostic significance of fatty acid synthase in pancreatic carcinoma, Anticancer Res, 27, 2523
  2. Anderson, 2007, Key stages in mammary gland development. Secretory activation in the mammary gland: it's not just about milk protein synthesis!, Breast Cancer Res, 9, 204, 10.1186/bcr1653 · DOI
  3. Bandyopadhyay, 2006, Mechanism of apoptosis induced by the inhibition of fatty acid synthase in breast cancer cells, Cancer Res, 66, 5934, 10.1158/0008-5472.CAN-05-3197 · DOI
  4. Bryant, 2009, PARP is activated at stalled forks to mediate Mre11-dependent replication restart and recombination, EMBO J, 28, 2601, 10.1038/emboj.2009.206 · DOI
  5. Chen, 2008, Structural enzymological studies of 2-enoyl thioester reductase of the human mitochondrial FAS II pathway: new insights into its substrate recognition properties, J Mol Biol, 379, 830, 10.1016/j.jmb.2008.04.041 · DOI
  6. Dantzer, 2000, Base excision repair is impaired in mammalian cells lacking Poly(ADP-ribose) polymerase-1, Biochemistry, 39, 7559, 10.1021/bi0003442 · DOI
  7. Fu, 2012, Balancing repair and tolerance of DNA damage caused by alkylating agents, Nat Rev Cancer, 12, 104, 10.1038/nrc3185 · DOI
  8. Gagne, 2008, Proteome-wide identification of poly(ADP-ribose) binding proteins and poly(ADP-ribose)-associated protein complexes, Nucleic Acids Res, 36, 6959, 10.1093/nar/gkn771 · DOI
  9. Gansler, 1997, Increased expression of fatty acid synthase (OA-519) in ovarian neoplasms predicts shorter survival, Hum Pathol, 28, 686, 10.1016/S0046-8177(97)90177-5 · DOI
  10. Hanahan, 2000, The hallmarks of cancer, Cell, 100, 57, 10.1016/S0092-8674(00)81683-9 · DOI · Paper page
  11. Hanahan, 2011, Hallmarks of cancer: the next generation, Cell, 144, 646, 10.1016/j.cell.2011.02.013 · DOI · Paper page
  12. Hegde, 2008, Early steps in the DNA base excision/single-strand interruption repair pathway in mammalian cells, Cell Res, 18, 27, 10.1038/cr.2008.8 · DOI
  13. Jackowski, 1994, Coordination of membrane phospholipid synthesis with the cell cycle, J Biol Chem, 269, 3858, 10.1016/S0021-9258(17)41939-9 · DOI
  14. Kao, 2013, Fatty acid synthase overexpression confers an independent prognosticator and associates with radiation resistance in nasopharyngeal carcinoma, Tumour Biol, 34, 759, 10.1007/s13277-012-0605-y · DOI
  15. Khodyreva, 2010, Apurinic/apyrimidinic (AP) site recognition by the 5'-dRP/AP lyase in poly(ADP-ribose) polymerase-1 (PARP-1), Proc Natl Acad Sci U S A, 107, 22090, 10.1073/pnas.1009182107 · DOI
  16. Knowles, 2007, Genome-wide changes accompanying knockdown of fatty acid synthase in breast cancer, BMC Genomics, 8, 168, 10.1186/1471-2164-8-168 · DOI
  17. Knowles, 2008, Inhibition of fatty-acid synthase induces caspase-8-mediated tumor cell apoptosis by up-regulating DDIT4, J Biol Chem, 283, 31378, 10.1074/jbc.M803384200 · DOI
  18. Kuhajda, 2000, Fatty-acid synthase and human cancer: new perspectives on its role in tumor biology, Nutrition, 16, 202, 10.1016/S0899-9007(99)00266-X · DOI
  19. Kuhajda, 2006, Fatty acid synthase and cancer: new application of an old pathway, Cancer Res, 66, 5977, 10.1158/0008-5472.CAN-05-4673 · DOI
  20. Liu, 2010, Biochemistry, molecular biology, and pharmacology of fatty acid synthase, an emerging therapeutic target and diagnosis/prognosis marker, Int J Biochem Mol Biol, 1, 69
  21. Liu, 2008, A new mechanism of drug resistance in breast cancer cells: fatty acid synthase overexpression-mediated palmitate overproduction, Mol Cancer Ther, 7, 263, 10.1158/1535-7163.MCT-07-0445 · DOI
  22. Liu, 2013, Fatty acid synthase causes drug resistance by inhibiting TNF-alpha and ceramide production, J Lipid Res, 54, 776, 10.1194/jlr.M033811 · DOI
  23. Maier, 2008, The crystal structure of a mammalian fatty acid synthase, Science, 321, 1315, 10.1126/science.1161269 · DOI
  24. Menendez, 2004, Inhibition of tumor-associated fatty acid synthase activity enhances vinorelbine (Navelbine)-induced cytotoxicity and apoptotic cell death in human breast cancer cells, Oncol Rep, 12, 411
  25. Menendez, 2007, Fatty acid synthase and the lipogenic phenotype in cancer pathogenesis, Nat Rev Cancer, 7, 763, 10.1038/nrc2222 · DOI · Paper page
  26. Menendez, 2004, Inhibition of tumor-associated fatty acid synthase hyperactivity induces synergistic chemosensitization of HER -2/neu -overexpressing human breast cancer cells to docetaxel (taxotere), Breast Cancer Res Treat, 84, 183, 10.1023/B:BREA.0000018409.59448.60 · DOI
  27. Menendez, 2005, Pharmacological and small interference RNA-mediated inhibition of breast cancer-associated fatty acid synthase (oncogenic antigen-519) synergistically enhances Taxol (paclitaxel)-induced cytotoxicity, Int J Cancer, 115, 19, 10.1002/ijc.20754 · DOI
  28. Menendez, 2005, Targeting fatty acid synthase-driven lipid rafts: a novel strategy to overcome trastuzumab resistance in breast cancer cells, Med Hypotheses, 64, 997, 10.1016/j.mehy.2004.09.027 · DOI
  29. Menendez, 2006, The antiobesity drug Orlistat induces cytotoxic effects, suppresses Her-2/neu (erbB-2) oncogene overexpression, and synergistically interacts with trastuzumab (Herceptin) in chemoresistant ovarian cancer cells, Int J Gynecol Cancer, 16, 219
  30. Ogino, 2008, Cohort study of fatty acid synthase expression and patient survival in colon cancer, J Clin Oncol, 26, 5713, 10.1200/JCO.2008.18.2675 · DOI
  31. Paris, 2010, Inhibition of phosphatidylcholine-specific phospholipase C downregulates HER2 overexpression on plasma membrane of breast cancer cells, Breast Cancer Res, 12, R27, 10.1186/bcr2575 · DOI
  32. Peetla, 2010, Drug resistance in breast cancer cells: biophysical characterization of and doxorubicin interactions with membrane lipids, Mol Pharm, 7, 2334, 10.1021/mp100308n · DOI
  33. Pizer, 1998, Pharmacological inhibitors of mammalian fatty acid synthase suppress DNA replication and induce apoptosis in tumor cell lines, Cancer Res, 58, 4611
  34. Pizer, 1996, Inhibition of fatty acid synthesis induces programmed cell death in human breast cancer cells, Cancer Res, 56, 2745
  35. Pizer, 1998, Fatty acid synthase expression in endometrial carcinoma: correlation with cell proliferation and hormone receptors, Cancer, 83, 528, 10.1002/(SICI)1097-0142(19980801)83:3<528::AID-CNCR22>3.0.CO;2-X · DOI
  36. Pizer, 2000, Malonyl-coenzyme-A is a potential mediator of cytotoxicity induced by fatty-acid synthase inhibition in human breast cancer cells and xenografts, Cancer Res, 60, 213
  37. Pizer, 1996, Inhibition of fatty acid synthesis delays disease progression in a xenograft model of ovarian cancer, Cancer Res, 56, 1189
  38. Pizer, 1996, Fatty acid synthase (FAS): a target for cytotoxic antimetabolites in HL60 promyelocytic leukemia cells, Cancer Res, 56, 745
  39. Pleschke, 2000, Poly(ADP-ribose) binds to specific domains in DNA damage checkpoint proteins, J Biol Chem, 275, 40974, 10.1074/jbc.M006520200 · DOI
  40. Puig, 2011, A novel inhibitor of fatty acid synthase shows activity against HER2+ breast cancer xenografts and is active in anti-HER2 drug-resistant cell lines, Breast Cancer Res, 13, R131, 10.1186/bcr3077 · DOI
  41. Rossi, 2003, Fatty acid synthase expression defines distinct molecular signatures in prostate cancer, Mol Cancer Res, 1, 707
  42. Sears, 2012, Complex cisplatin-double strand break (DSB) lesions directly impair cellular non-homologous end-joining (NHEJ) independent of downstream damage response (DDR) pathways, J Biol Chem, 287, 24263, 10.1074/jbc.M112.344911 · DOI
  43. Swinnen, 2003, Fatty acid synthase drives the synthesis of phospholipids partitioning into detergent-resistant membrane microdomains, Biochem Biophys Res Commun, 302, 898, 10.1016/S0006-291X(03)00265-1 · DOI
  44. Takahiro, 2003, Expression of fatty acid synthase as a prognostic indicator in soft tissue sarcomas, Clin Cancer Res, 9, 2204
  45. Vazquez-Martin, 2007, Inhibition of fatty acid synthase (FASN) synergistically enhances the efficacy of 5-fluorouracil in breast carcinoma cells, Oncol Rep, 18, 973
  46. Visca, 2004, Fatty acid synthase (FAS) is a marker of increased risk of recurrence in lung carcinoma, Anticancer Res, 24, 4169
  47. Yang, 2011, Role of fatty acid synthase in gemcitabine and radiation resistance of pancreatic cancers, Int J Biochem Mol Biol, 2, 89
  48. Zhang, 2003, Cloning, expression, characterization, and interaction of two components of a human mitochondrial fatty acid synthase. Malonyltransferase and acyl carrier protein, J Biol Chem, 278, 40067, 10.1074/jbc.M306121200 · DOI

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Metadata

Authors
Wu, X., Qin, L., Fako, V., & Zhang, J.-T.
Affiliations
Indiana University Melvin and Bren Simon Comprehensive Cancer Center (US)
Corresponding author
Zhang, Jian-Ting
ORCID
Venue
Advances in Biological Regulation
Publisher
Elsevier BV
Published
2014-01
Volume
54
Pages
214-221
ISSN
2212-4926 (ISSN-L)
DOI
10.1016/j.jbior.2013.09.004
OpenAlex
W2034590888
Cited by
82
References
2
Citations by year
2026: 7 · 2025: 6 · 2024: 6 · 2023: 2 · 2022: 7 · 2021: 11 · 2020: 8 · 2019: 9 · 2018: 4 · 2017: 3 · 2016: 9 · 2015: 5 · 2014: 4
FWCI
0.50
Type
journal article
Language
en
Open access
closed
Licence
Locations
  • Advances in Biological Regulation (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › Cancer, Lipids, and Metabolism
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Biochemistry › Lipid metabolism and biosynthesis
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Sphingolipid Metabolism and Signaling
Keywords
fatty acid synthase, drug resistance, radioresistance (biology), de novo lipogenesis, cancer, apoptosis, DNA repair, gene expression regulation, acquired resistance
MeSH terms
Animals, Antineoplastic Agents, Humans, Neoplasms, Gene Expression Regulation, Neoplastic, Apoptosis, Drug Resistance, Neoplasm, Fatty Acid Synthases

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