Prognostic implications of coronary CT angiography-derived quantitative markers for the prediction of major adverse cardiac events
Abstract
Objective To evaluate quantitative markers derived from coronary CT angiography (coronary CTA) for the prediction of major adverse cardiac events (MACE). Materials and methods Pooled data from two centers in the US and Europe were retrospectively analyzed. Forty-six patients (65.5 ± 8.1 years, 62% male) with suspected coronary artery disease (CAD) who had undergone dual-source CCTA and had experienced MACE within 12 months were included and compared to a Framingham risk score matched cohort (n = 46) without MACE. Various quantitative markers derived from coronary CTA were compared between both groups: Total plaque volume (TPV), calcified and non-calcified plaque volumes (CPV and NCPV), plaque burden (%), remodeling index, lesion length, presence of Napkin-ring sign, segment involvement score (SIS), and segment stenosis score (SSS). Discriminatory power of these markers for predicting MACE was assessed. Results Patients with MACE had significantly more obstructive CAD with higher plaque burden, SSS, and SIS (all p 3 vs. 76.3 mm 3 ), NCPV (67.3 mm 3 vs. 56.1 mm 3 ), plaque burden (66.3% vs. 44.9%), greater lesion length (23.1 mm vs. 19.2 mm), and higher prevalence of Napkin-ring sign (63% vs. 32%) (all p Conclusion Coronary CTA-derived markers portend predictive value for MACE on a per-patient (plaque burden and SSS) and per-lesion level (lesion length, plaque burden, remodeling index, and Napkin-ring sign). A combination of markers added to the Framingham risk score has the hi…
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
The SSS and SIS have demonstrated clinical validity in detecting major adverse cardiac events in multiple populations.
“The SSS and SIS have demonstrated clinical validity in detecting major adverse cardiac events in multiple populations.15–19”
From Lifelong endurance exercise and its relation with coronary atherosclerosis (2023) · cites this paper as [16]
No citation lists for this paper
No citation lists for this paper yet — checked again daily.
References 28 · Cited by 73
- Authors
- Tesche, C., Plank, F., De Cecco, C. N., Duguay, T. M., Albrecht, M. H., Varga-Szemes, A., Bayer, R. R., Yang, J., Jacks, I. L., Gramer, B. M., Ebersberger, U., Hoffmann, E., Chiaramida, S. A., Feuchtner, G., & Schoepf, U. J.
- Affiliations
- Medical University of South Carolina (US)
- Innsbruck Medical University (AT)
- TUM Klinikum (DE)
- München Klinik Bogenhausen (DE)
- Corresponding author
- Schoepf, U. Joseph
- ORCID
- Venue
- Journal of Cardiovascular Computed Tomography
- Publisher
- Elsevier BV
- Published
- 2016-11
- Volume
- 10
- Issue
- 6
- Pages
- 458-465
- ISSN
- 1876-861X (ISSN-L)
- 1934-5925
- OpenAlex
- W2506925819
- Cited by
- 73
- References
- 28
- Citations by year
- 2026: 4 · 2025: 3 · 2024: 6 · 2023: 5 · 2022: 9 · 2021: 10 · 2020: 12 · 2019: 9 · 2018: 7 · 2017: 8
- FWCI
- 6.96
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Journal of cardiovascular computed tomography (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Radiology, Nuclear Medicine and Imaging › Cardiac Imaging and Diagnostics
- Health Sciences › Medicine › Surgery › Coronary Interventions and Diagnostics
- Health Sciences › Medicine › Pulmonary and Respiratory Medicine › Coronary Artery Anomalies
- Keywords
- major adverse cardiac events, coronary CT angiography, coronary artery disease, plaque burden, napkin-ring sign, remodeling index, lesion length, segment involvement score, plaque volume, Framingham risk score, risk prediction, coronary plaque imaging, prognostic factors, dual-source CT, coronary artery calcification
- MeSH terms
- Computed Tomography Angiography, Aged, Coronary Artery Disease, Coronary Vessels, Female, Germany, Humans, Male, Middle Aged, Predictive Value of Tests, Prognosis, Retrospective Studies, ROC Curve, Severity of Illness Index, South Carolina, Time Factors, Coronary Angiography, Area Under Curve, Coronary Stenosis, Plaque, Atherosclerotic, Vascular Calcification, Multidetector Computed Tomography
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
