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Chronic Mycobacterium abscessus infection and lung function decline in cystic fibrosis
Open accessAbstract
Background Although nontuberculous mycobacteria (NTM) are recognized pathogens in cystic fibrosis (CF), associations with clinical outcomes remain unclear. Methods Microbiological data was obtained from 1216 CF patients over 8 years (481±55 patients/year). Relationships to clinical outcomes were examined in the subset (n=271, 203±23 patients/year) with longitudinal data. Results Five hundred thirty-six of 4862 (11%) acid-fast bacilli (AFB) cultures grew NTM, with Mycobacterium abscessus (n=298, 55.6%) and Mycobacterium avium complex (n=190, 35.4%) most common. Associated bacterial cultures grew Stenotrophomonas or Aspergillus species more often when NTM were isolated (18.2% vs. 8.4% and 13.9% vs. 7.2%, respectively, p<0.01). After controlling for confounders, patients with chronic M. abscessus infection had greater rates of lung function decline than those with no NTM infection (−2.52 vs. −1.64% predicted FEV1/year, p<0.05). Conclusions NTM infection is common in CF and associated with particular pathogens. Chronic M. abscessus infection is associated with increased lung function decline.
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Infection or colonization with multidrug-resistant organisms including Burkholderia cepacia complex, Pseudomonas aeruginosa, and nontuberculous mycobacteria, especially M. abscessus, increases lung function decline or death without transplant in advanced cystic fibrosis.
“Infection or colonization with multi-drug resistant organisms including Burkholderia cepacia complex, Pseudomonas aeruginosa, and nontuberculous mycobacteria (M. abscessus in particular) have been shown to increase the rate of lung function decline or death without transplant in advanced CF.(245, 247, 254, 258, 262)”
From Consensus document for the selection of lung transplant candidates: An update from the International Society for Heart and Lung Transplantation. (2021) · cites this paper as [262]
The Abstract Results and Conclusions report that chronic M. abscessus infection was associated with faster lung-function decline in patients with CF. The Discussion cautions that the study demonstrates an association, not causation. This paper does not establish the claim about death without transplant or specifically advanced CF, nor does it provide the claimed outcomes for Burkholderia cepacia complex or P. aeruginosa. (LLM, conf=0.88)
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References 23 · Cited by 410
Metadata
- Authors
- Esther, C. R., Esserman, D. A., Gilligan, P., Kerr, A., & Noone, P. G.
- Affiliations
- University of North Carolina at Chapel Hill (US)
- Corresponding author
- Esther, Charles R.
- Venue
- Journal of Cystic Fibrosis
- Publisher
- Elsevier BV
- Published
- 2010-03
- Volume
- 9
- Issue
- 2
- Pages
- 117-123
- ISSN
- 1569-1993 (ISSN-L)
- PMC
- PMC3837580
- OpenAlex
- W2026042024
- Semantic Scholar
- 0d82f161e8b79c19c4b37a0d812776feea838474
- Cited by
- 410
- References
- 23
- Citations by year
- 2026: 17 · 2025: 18 · 2024: 24 · 2023: 32 · 2022: 39 · 2021: 28 · 2020: 23 · 2019: 34 · 2018: 35 · 2017: 27 · 2016: 26 · 2015: 32 · 2014: 24 · 2013: 17 · 2012: 24
- FWCI
- 11.90
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- Journal of Cystic Fibrosis (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Funders
- NIH (UL1RR025747)
- Topics
- Health Sciences › Medicine › Epidemiology › Mycobacterium research and diagnosis
- Health Sciences › Medicine › Pulmonary and Respiratory Medicine › Cystic Fibrosis Research Advances
- Health Sciences › Medicine › Microbiology (medical) › Infections and bacterial resistance
- Keywords
- Mycobacterium abscessus, nontuberculous mycobacteria, lung function decline, Mycobacterium avium complex, Stenotrophomonas, Aspergillus, acid-fast bacilli, FEV1, clinical outcomes
- MeSH terms
- Adolescent, Adult, Aspergillus, Child, Chronic Disease, Cystic Fibrosis, Female, Humans, Longitudinal Studies, Lung, Male, Mycobacterium, Mycobacterium Infections, Respiratory Function Tests, Stenotrophomonas, Young Adult
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