Regional and cellular distribution patterns of insulin-degrading enzyme in the adult human brain and pituitary
Abstract
The regional distribution and cellular localization of insulin-degrading enzyme (IDE) was studied in adult human brain and pituitary by means of immunhistochemistry. We show that the enzyme is widely but unevenly distributed in human brain, with hypothalamic neurons showing the strongest immunoreaction. Strong to moderate immunostaining for the enzyme was observed in multiple cortical areas, hippocampus, cerebellum, and brain stem. Cellularly, IDE was mainly confined to neurons, but it was also present in oligodendrocytes, choroid plexus, and some blood vessel endothelial cells. A strong immunoreaction was seen in a subset of adenohypophysial cells. Some immunolabeling was also present in the neurohypophysis. The putative importance of the distribution of the enzyme in brain and pituitary is discussed in relation to its main known substrates, insulin, Abeta, and beta-endorphin.
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IDE is produced and secreted by neurons, oligodendrocytes, and microglia in the brain.
“IDE is produced and secreted by neurons, oligodendrocytes, and microglia in the brain [33]”
From Pharmacological ablation of astrocytes reduces Aβ degradation and synaptic connectivity in an ex vivo model of Alzheimer’s disease (2021) · cites this paper as [33]
Cites
Brain insulin and insulin receptors in aging and sporadic Alzheimer’s disease
Frölich, L., Blum-Degen, D., Bernstein, H.-G., Engelsberger, S., Humrich, J., Laufer, S., Muschner, D., Thalheimer, A., Türk, A., Hoyer, S., et al. (1998) · Journal of Neural Transmission · doi:10.1007/s007020050068 · Cited by 748 · see citing works
Self-citationUnger, J. W., & Lange, W. (1997) · Cell and Tissue Research · doi:10.1007/s004410050833 · Cited by 45 · see citing works
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Mechanisms of Aβ Clearance and Degradation by Glial Cells
Ries, M., & Sastre, M. (2016) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2016.00160 · Cited by 527 · see citing works
“In the brain, IDE is synthesized and secreted by neurons, oligodendrocytes, and microglia (Bernstein et al., 2008), where it is released via exosomes (Tamboli et al., 2010) especially acting on extracellular Aβ deposits.”
BackgroundDavis, N., Mota, B. C., Stead, L., Palmer, E. O. C., Lombardero, L., Rodríguez-Puertas, R., de Paola, V., Barnes, S. J., & Sastre, M. (2021) · Journal of Neuroinflammation · doi:10.1186/s12974-021-02117-y · Cited by 65 · see citing works
- Authors
- Bernstein, H.-G., Lendeckel, U., Bukowska, A., Ansorge, S., Ernst, T., Stauch, R., Trübner, K., Steiner, J., Dobrowolny, H., & Bogerts, B.
- Affiliations
- University Hospital Magdeburg (DE)
- Otto-von-Guericke-Universität Magdeburg (DE)
- University of Duisburg-Essen (DE)
- Corresponding author
- Bernstein, Hans-Gert
- Venue
- Journal of Chemical Neuroanatomy
- Publisher
- Elsevier BV
- Published
- 2008-03
- Volume
- 35
- Issue
- 2
- Pages
- 216-224
- ISSN
- 0891-0618 (ISSN-L)
- OpenAlex
- W2087150397
- Cited by
- 22
- References
- 2
- Citations by year
- 2025: 1 · 2023: 3 · 2022: 2 · 2021: 4 · 2019: 2 · 2018: 2 · 2016: 1 · 2014: 2 · 2013: 1 · 2012: 1
- FWCI
- 0.68
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Journal of Chemical Neuroanatomy (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Physiology › Alzheimer's disease research and treatments
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuropeptides and Animal Physiology
- Social Sciences › Psychology › Social Psychology › Neuroendocrine regulation and behavior
- Keywords
- insulin-degrading enzyme, human brain, pituitary gland, regional distribution, subcellular localization, hypothalamic neurons, anterior pituitary, neurohypophysis, oligodendrocytes, choroid plexus, insulin, amyloid-beta, beta-endorphin, enzyme substrates
- MeSH terms
- Adult, Brain, Cadaver, Cause of Death, Female, Humans, Immunohistochemistry, Insulysin, Male, Middle Aged, Pituitary Gland, Postmortem Changes
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