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Cited by 401Heart Failure Treatment and ManagementCardiovascular Function and Risk FactorsDiabetes Treatment and Management

The DOI matches its Crossref record; 59 of the 59 references it cites were found in a registry or an index.

Impact of Diabetes on Epidemiology, Treatment, and Outcomes of Patients With Heart Failure

Open access
Dei Cas, Alessandra, Khan, Sadiya S., Butler, Javed, Mentz, Robert J., Bonow, Robert O., Avogaro, Angelo, Tschoepe, Diethelm, Doehner, Wolfram, Greene, Stephen J., Senni, Michele, Gheorghiade, Mihai, Fonarow, Gregg C.·2015·JACC Heart Failure
DOI 10.1016/j.jchf.2014.08.004
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Abstract

The prevalence of patients with concomitant heart failure (HF) and diabetes mellitus (DM) continues to increase with the general aging of the population. In patients with chronic HF, prevalence of DM is 24% compared with 40% in those hospitalized with worsening HF. Patients with concomitant HF and DM have diverse pathophysiologic, metabolic, and neurohormonal abnormalities that potentially contribute to worse outcomes than those without comorbid DM. In addition, although stable HF outpatients with DM show responses that are similar to those of patients without DM undergoing evidence-based therapies, it is unclear whether hospitalized HF patients with DM will respond similarly to novel investigational therapies. These data support the need to re-evaluate the epidemiology, pathophysiology, and therapy of HF patients with concomitant DM. This paper discusses the role of DM in HF patients and underscores the potential need for the development of targeted therapies.

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Authors
Dei Cas, A., Khan, S. S., Butler, J., Mentz, R. J., Bonow, R. O., Avogaro, A., Tschoepe, D., Doehner, W., Greene, S. J., Senni, M., Gheorghiade, M., & Fonarow, G. C.
Affiliations
  • Northwestern University (US)
  • Stony Brook University (US)
  • Duke Medical Center (US)
  • University of Padua (IT)
  • University Hospitals of the Ruhr-University of Bochum (DE)
  • Center for Stroke Research Berlin (DE)
  • Ospedale Papa Giovanni XXIII (IT)
  • University of California, Los Angeles (US)
Corresponding author
Fonarow, Gregg C.
ORCID
Venue
JACC Heart Failure
Publisher
Elsevier BV
Published
2015-02
Volume
3
Issue
2
Pages
136-145
ISSN
2213-1779 (ISSN-L)
DOI
10.1016/j.jchf.2014.08.004
OpenAlex
W2072535229
Cited by
401
References
59
Citations by year
2026: 8 · 2025: 28 · 2024: 33 · 2023: 17 · 2022: 55 · 2021: 69 · 2020: 55 · 2019: 31 · 2018: 40 · 2017: 20 · 2016: 26 · 2015: 19
FWCI
6.04
Type
journal article
Language
en
Open access
Licence
Locations
  • JACC Heart Failure (publishedVersion)
  • PubMed (publishedVersion)
  • BOA (University of Milano-Bicocca) (submittedVersion)
Funders
  • Amgen
  • Boston Scientific Corporation
  • National Institutes of Health
  • Agency for Healthcare Research and Quality
Topics
  • Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Heart Failure Treatment and Management
  • Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiovascular Function and Risk Factors
  • Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes Treatment and Management
Keywords
heart failure, diabetes mellitus, comorbidities, prevalence, pathophysiology, metabolic abnormalities, treatment outcomes, targeted therapy
MeSH terms
Adrenergic beta-Antagonists, Angiotensin-Converting Enzyme Inhibitors, Autonomic Nervous System Diseases, Diabetes Mellitus, Diuretics, Fatty Acids, Nonesterified, Heart, Heart Failure, Humans, Insulin Resistance, Mitochondria, Heart, Myocardium, Renin-Angiotensin System, Renal Insufficiency, Vascular Remodeling

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