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Cited by 165Heart Failure Treatment and ManagementDiabetes Treatment and ManagementCardiovascular Function and Risk Factors

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Effects of the Novel Long-Acting GLP-1 Agonist, Albiglutide, on Cardiac Function, Cardiac Metabolism, and Exercise Capacity in Patients With Chronic Heart Failure and Reduced Ejection Fraction

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Lepore, John J., Olson, Eric, Demopoulos, Laura, Haws, Thomas, Fang, Zixing, Barbour, April M., Fossler, Michael, Davila-Roman, Victor G., Russell, Stuart D., Gropler, Robert J.·2016·JACC: Heart Failure
DOI 10.1016/j.jchf.2016.01.008
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Abstract

Objectives This study sought to determine if glucagon-like peptide (GLP)-1 ameliorates myocardial metabolic abnormalities in chronic heart failure.Background Albiglutide (GSK716155) is a GLP-1 agonist indicated for type 2 diabetes.Methods We performed a randomized, placebo-controlled study evaluating 12 weeks of albiglutide in New York Heart Association II or III subjects with ejection fraction <40%. Subjects received weekly placebo (n = 30) or albiglutide 3.75 mg (n = 12), 15 mg (n = 13), or 30 mg (n = 27). The primary comparison was between albiglutide 30 mg and placebo. Assessments included echocardiography, 6-minute-walk test, and peak oxygen consumption. In a subgroup of patients, myocardial glucose and oxygen use were assessed. Endpoints are reported as change from baseline ± SE.Results Albiglutide 30 mg compared with placebo did not improve change from baseline in left ventricular ejection fraction (2.4% [1.1%] vs. 4.4% [1.1%]; p = 0.22), 6-min walk test (18 [12] m vs. 9 [11] m; p = 0.58), myocardial glucose use (p = 0.59), or oxygen use (p = 0.25). In contrast, albiglutide 30 mg versus placebo improved change from baseline in peak oxygen consumption (0.9 [0.5] ml/kg/min vs. -0.6 [0.5] ml/kg/min; p = 0.02). Albiglutide was well tolerated.Conclusions Although there was no detectable effect of albiglutide on cardiac function or myocardial glucose use, there was a modest increase in peak oxygen consumption, which could have been mediated by noncardiac effects. (A Multi-center, Placebo-controlled Study to Evaluate the Safety of GSK716155 and Its Effects on Myocardial Metabolism, Myocardial Function, and Exercise Capacity in Patients With NYHA Class II/III Congestive Heart Failure; NCT01357850).

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Authors
Lepore, J. J., Olson, E., Demopoulos, L., Haws, T., Fang, Z., Barbour, A. M., Fossler, M., Davila-Roman, V. G., Russell, S. D., & Gropler, R. J.
Affiliations
  • GlaxoSmithKline (United States) (US)
  • Johns Hopkins University (US)
  • Washington University in St. Louis (US)
Corresponding author
Lepore, John J.
ORCID
Venue
JACC: Heart Failure
Publisher
Elsevier BV
Published
2016-07
Volume
4
Issue
7
Pages
559-566
ISSN
2213-1779 (ISSN-L)
DOI
10.1016/j.jchf.2016.01.008
OpenAlex
W2335779504
Cited by
165
References
31
Citations by year
2026: 12 · 2025: 18 · 2024: 23 · 2023: 15 · 2022: 12 · 2021: 16 · 2020: 10 · 2019: 18 · 2018: 13 · 2017: 17 · 2016: 11
FWCI
16.22
Type
journal article
Language
en
Open access
Licence
Locations
  • JACC Heart Failure (publishedVersion)
  • PubMed (publishedVersion)
Funders
GlaxoSmithKline (NCT01357850)
Topics
  • Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Heart Failure Treatment and Management
  • Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes Treatment and Management
  • Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiovascular Function and Risk Factors
Keywords
albiglutide, GLP-1 receptor agonists, myocardial metabolism, peak oxygen uptake, exercise capacity, left ventricular ejection fraction, cardiac function
MeSH terms
Walk Test, Positron Emission Tomography Computed Tomography, Adult, Aged, Carbon Radioisotopes, Chronic Disease, Echocardiography, Female, Glucose, Heart Failure, Humans, Male, Middle Aged, Myocardium, Oxygen Consumption, Quality of Life, Stroke Volume, Exercise Tolerance, Radiopharmaceuticals, Fluorodeoxyglucose F18, Glucagon-Like Peptide 1, Incretins

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