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Cited by 346

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Electrospray ionization with low-energy collisionally activated dissociation tandem mass spectrometry of glycerophospholipids: Mechanisms of fragmentation and structural characterization

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Hsu, Fong-Fu, Turk, J.·2009·Journal of Chromatography B

Abstract

This review describes the use of low-energy collisionally activated dissociation (CAD) with both tandem quadrupole and ion-trap mass spectrometry toward to structural characterization of glycerophospholipids (GPLs), including classes of glycerophosphocholine, glycerophosphoethanolamine, glycerophosphoserine, glycerophosphoglycerol glycerophosphoinositol and glycerophosphatidic acid, as well as their lyso-, plasmanyl-, and plasmenylphospholipid subclasses.. The mechanisms underlying the fragmentation processes leading to structural characterization of GPLs in various ion forms desorbed by electrospray ionization in the positive-ion and negative-ion modes are also discussed. The tandem mass spectrometric approaches afford the identification of the polar head group, the fatty acid substituents and the location of the radyl groups on the glycerol backbone of all the GPLs.

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Crossref · 10.1016/j.jchromb.2009.02.033

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Metadata

Authors
Hsu, F.-F., & Turk, J.
Venue
Journal of Chromatography B
Publisher
Elsevier BV
Published
2009-09
Volume
877
Issue
26
Pages
2673-2695
ISSN
1570-0232 (ISSN-L)
OpenAlex
W2041235251
Cited by
346
References
1
FWCI
9.47
Type
journal article
Language
en
Open access
green

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