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Cited by 40Pickering emulsions and particle stabilizationProteins in Food SystemsSurfactants and Colloidal Systems

Tuning morphology of Pickering emulsions stabilised by biodegradable PLGA nanoparticles: How PLGA characteristics influence emulsion properties

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Robin, Baptiste, Albert, Claire, Beladjine, Mohamed, Legrand, François-Xavier, Geiger, Sandrine, Moine, Laurence, Nicolas, Valérie, Canette, Alexis +4 more·2021·Journal of Colloid and Interface Science
DOI 10.1016/j.jcis.2021.03.061
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Abstract

In this study, we proved that the stabilisation of Pickering emulsions by polymer nanoparticles (NPs) heavily depends on polymer characteristics. We prepared NPs with four poly(lactide-co-glycolide) polymers (PLGA), of different molar masses (14,000 and 32,000 g/mol) and end groups (acid or alkylester). NPs were either bare (without stabilising polymer) or covered by polyvinyl alcohol (PVA). Pickering emulsions were prepared by mixing NP aqueous suspensions with various amounts of oil (Miglyol 812 N). First, NP wettability was directly affected by PLGA end group: ester-ending PLGA led to more hydrophobic NPs, compared to acid-ending PLGA. This effect of the end group could be slightly enhanced with smaller molar mass. Thus, bare PLGA NPs stabilised different types of emulsions (W/O/W and W/O), following Finkle's rule. However, the effect of PLGA characteristics was masked when NPs were covered by PVA, as PVA drove the stabilisation of O/W emulsions. Secondly, PLGA molar mass and end group also influenced its glass transition temperature (T g), with spectacular consequences on emulsion formation. Indeed, the shortest ester-ending PLGA exhibited a T g close to room temperature, when measured in the emulsion. This T g, easily exceeded during emulsification process, led to a soft solid emulsion, stabilised by a network of NP debris.

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  • PLGA's ester bond linkages enable controlled hydrolysis, and its mechanical flexibility allows fabrication of thin, conformable films that adhere to tissue surfaces without causing irritation or excessive mechanical stress.

    “Its ester bond linkages enable controlled hydrolysis, while its mechanical flexibility allows for the fabrication of thin, conformable films that adhere to tissue surfaces without causing irritation or excessive mechanical stress (Figure 10C) [229].”

    From Biomaterials in Postoperative Adhesion Barriers and Uterine Tissue Engineering (2025) · cites this paper as [229]

    The Introduction states that PLGA’s ester-linked units can be hydrolysed and that its degradation rate can be tuned. Sections 2.4.3 and 3.2.1 describe PLGA films used for wettability measurements, but do not support the claims that mechanical flexibility enables thin, tissue-conformable films or that such films adhere without irritation or excessive stress. No page numbers are available in our copy. (LLM, conf=0.89)

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Authors
Robin, B., Albert, C., Beladjine, M., Legrand, F.-X., Geiger, S., Moine, L., Nicolas, V., Canette, A., Trichet, M., Tsapis, N., Agnely, F., & Huang, N.
Affiliations
  • Centre National de la Recherche Scientifique (FR)
  • Université Paris-Saclay (FR)
Corresponding author
Huang, Nicolas
ORCID
Venue
Journal of Colloid and Interface Science
Publisher
Elsevier BV
Published
2021-08
Volume
595
Pages
202-211
ISSN
0021-9797 (ISSN-L)
DOI
10.1016/j.jcis.2021.03.061
OpenAlex
W3139119380
Cited by
40
References
2
Citations by year
2026: 6 · 2025: 6 · 2024: 10 · 2023: 6 · 2022: 9 · 2021: 3
FWCI
2.13
Type
journal article
Language
en
Open access
Licence
Locations
  • Journal of Colloid and Interface Science (publishedVersion)
  • PubMed (publishedVersion)
  • HAL (submittedVersion, other-oa)
  • Oskar-Bordeaux (Universite de Bordeaux) (submittedVersion)
Funders
French National Research Agency
Topics
  • Physical Sciences › Materials Science › Materials Chemistry › Pickering emulsions and particle stabilization
  • Life Sciences › Agricultural and Biological Sciences › Food Science › Proteins in Food Systems
  • Physical Sciences › Chemistry › Organic Chemistry › Surfactants and Colloidal Systems
Keywords
Pickering emulsions, PLGA nanoparticles, poly(lactic-co-glycolic acid), polymer end groups, molar mass effects, polyvinyl alcohol coating, glass transition temperature, emulsion morphology, oil-in-water emulsions, water-in-oil-in-water emulsion

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Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

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