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Engineered platelet cell motors for boosted cancer radiosensitization

Liu, Wei, Nie, Hongmei, Li, He, Liu, Ya, Tian, Maoye, Wang, Shuhuai, Yang, Yuwei, Long, Wei·2024·Journal of Colloid and Interface Science
DOI 10.1016/j.jcis.2023.12.091
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Abstract

Design of engineered cells to target and deliver nanodrugs to the hard-to-reach regions has become an exciting research area. However, the limited penetration and retention of cell-based carriers in tumor tissue restricted their therapeutic efficiency. Inspired by the enhanced delivery behavior of mobile micro/nanomotors, herein, urease-powered platelet cell motors (PLT@Au@Urease) capable of active locomotion, tumor targeting, and radiosensitizers delivery were designed for boosting radiosensitization. The engineered platelet cell motors were constructed by in situ synthesis and loading of radiosensitizers gold nanoparticles in platelets, and then conjugation with urease as the engine. Under physiological concentration of urea, thrust around PLT@Au@Urease motors can be generated via the biocatalytic reactions of urease, leading to rapid tumor cell targeting and enhanced cellular uptake of radiosensitizers. Encouragingly, in comparison with engineered PLT without propulsion capability (PLT@Au), the self-propelled PLT@Au@Urease motors could significantly increase intracellular ROS level and exacerbate nuclear DNA damage induced by γ-radiation, resulting in a remarkably high sensitization enhancement rate (1.89) than that of PLT@Au (1.08). In vivo experiments with 4 T1-bearing mice demonstrated that PLT@Au@Urease in combination with radiation therapy possessed good antitumor performance. Such an intelligent cell motor would provide a promising approach to enhance radiosensitizat…

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Metadata

Authors
Liu, W., Nie, H., Li, H., Liu, Y., Tian, M., Wang, S., Yang, Y., & Long, W.
Venue
Journal of Colloid and Interface Science
Publisher
Elsevier BV
Published
2024-03
Volume
658
Pages
540-552
ISSN
0021-9797
DOI
10.1016/j.jcis.2023.12.091
Cited by
21
References
1
Language
en
Licence
Funders
  • Chinese Academy of Meteorological Sciences (2021-I2M-1-042, 2022-I2M-2-003)
  • Fundamental Research Funds for the Central Universities (3332022067, 3332023064)
  • CAMS Innovation Fund for Medical Sciences

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CoChat. (2026). Citation check: Engineered platelet cell motors for boosted cancer radiosensitization. https://app.cochat.ai/papers/10.1016/j.jcis.2023.12.091
The paper
Liu, W., Nie, H., Li, H., Liu, Y., Tian, M., Wang, S., Yang, Y., & Long, W. (2024). Engineered platelet cell motors for boosted cancer radiosensitization. Journal of Colloid and Interface Science. https://doi.org/10.1016/j.jcis.2023.12.091