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Multiple imputation of missing repeated outcome measurements did not add to linear mixed-effects models
Abstract
Objective To assess the added value of multiple imputation (MI) of missing repeated outcomes measures in longitudinal data sets analyzed with linear mixed-effects (LME) models.Study design and setting Data were used from a trial on the effects of Rosuvastatin on rate of change in carotid intima-media thickness (CIMT). The reference treatment effect was derived from a complete data set. Scenarios and proportions of missing values in CIMT measurements were applied and LME analyses were used before and after MI. The added value of MI, in terms of bias and precision, was assessed using the mean-squared error (MSE) of the treatment effects and coverage of the 95% confidence interval.Results The reference treatment effect was -0.0177 mm/y. The MSEs for LME analysis without and with MI were similar in scenarios with up to 40% missing values. Coverage was large in all scenarios and was similar for LME with and without MI.Conclusion Our study empirically shows that MI of missing end point data before LME analyses does not increase precision in the estimated rate of change in the end point. Hence, MI had no added value in this setting and standard LME modeling remains the method of choice.
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“Linear mixed modelling has been demonstrated to control for missing data, and therefore, multiple imputation was not required (Peters et al., 2012;Twisk et al., 2013).”
From Exercise combined with Acceptance and Commitment Therapy for chronic pain: One-year follow-up from a randomized controlled trial (2024) · cites this paper as Peters et al., 2012
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“Therefore, patterns of missingness were not found to be MNAR and the decision to continue the analysis with the available data was made [84,85].”
From Negative and positive affect regulation in a transdiagnostic internet-based protocol for emotional disorders: Randomized controlled trial (2021) · cites this paper as [85]
Citations
Cites
An Introduction to the Bootstrap
Efron, B., & Tibshirani, R. J. (1994) · doi:10.1201/9780429246593 · Cited by 40,500
An Introduction to the Bootstrap
Efron, B., & Tibshirani, R. J. (1993) · doi:10.1007/978-1-4899-4541-9 · Cited by 21,230
Multiple Imputation for Nonresponse in Surveys
Rubin, D. B. (1987) · Wiley Series in Probability and Statistics · doi:10.1002/9780470316696 · Cited by 20,701
Statistical Analysis With Missing Data
Lahiff, M., Little, R. J. A., & Rubin, D. B. (1989) · Journal of the American Statistical Association · doi:10.2307/2289883 · Cited by 17,385
mice: Multivariate Imputation by Chained Equations in R
Buuren, S. V., & Groothuis-Oudshoorn, K. (2011) · Journal of Statistical Software · doi:10.18637/jss.v045.i03 · Cited by 13,870
Mixed-Effects Models in Sand S-PLUS
Pinheiro, J. C., & Bates, D. M. (2000) · Statistics and Computing · doi:10.1007/978-1-4419-0318-1 · Cited by 11,187
Mixed-Effects Models in S and S-PLUS
(2001) · Technometrics · doi:10.1198/tech.2001.s574 · Cited by 9,278
Sterne, J. A. C., White, I. R., Carlin, J. B., Spratt, M., Royston, P., Kenward, M. G., Wood, A. M., & Carpenter, J. R. (2009) · BMJ · doi:10.1136/bmj.b2393 · Cited by 7,299
Missing data analysis: making it work in the real world
Graham, J. W. (2009) · Annual Review of Psychology · doi:10.1146/annurev.psych.58.110405.085530 · Cited by 6,163
Review: a gentle introduction to imputation of missing values.
Donders, A. R. T., van der Heijden, G. J. M. G., Stijnen, T., & Moons, K. G. M. (2006) · Journal of Clinical Epidemiology · doi:10.1016/j.jclinepi.2006.01.014 · Cited by 2,582
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Items 101–165 of 165
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Cavell, T. A., Gregus, S. J., Craig, J. T., Pastrana, F. A., & Rodríguez, J. H. (2018) · Children and Youth Services Review · doi:10.1016/j.childyouth.2018.04.045 · Cited by 8
The Bone, Exercise, Alendronate, and Caloric Restriction (BEACON) trial design and methods
Beavers, K. M., Wolle, B. R., Ard, J. D., Beavers, D. P., Biehl, O., Brubaker, P. H., Burghardt, A. J., Calderone, C. T., Carballido‐Gamio, J., Fanning, J. T., et al. (2024) · Contemporary Clinical Trials · doi:10.1016/j.cct.2024.107692 · Cited by 7
Boudreau, F., Dagenais, G. R., de Vries, H., Walthouwer, M. J. L., Côté, J., Turbide, G., Bourlaud, A.-S., & Poirier, P. (2020) · Health Psychology and Behavioral Medicine · doi:10.1080/21642850.2020.1850287 · Cited by 6
Massage Impact on Pain in Opioid-dependent Patients in Substance Use Treatment
Wiest, P., Asphaug, M., Carr, K. E., Gowen, L., & Hartnett, M. (2015) · International Journal of Therapeutic Massage & Bodywork: Research, Education, & Practice · doi:10.3822/ijtmb.v8i1.257 · Cited by 6
Andersson, H. W., & Nordfjærn, T. (2020) · Addictive Behaviors Reports · doi:10.1016/j.abrep.2020.100285 · Cited by 6
Anaby, D., Avery, L. M., Palisano, R. J., Levin, M. F., Khayargoli, P., Hsieh, Y., Gorter, J. W., Teplicky, R., & BEYOND Consultant Team (2023) · Developmental Medicine & Child Neurology · doi:10.1111/dmcn.15822 · Cited by 6
Effect of expressive and neutral writing on respiratory sinus arrhythmia response over time
Sheerin, C. M., Konig, A., Eonta, A. M., & Vrana, S. R. (2018) · Journal of Behavior Therapy and Experimental Psychiatry · doi:10.1016/j.jbtep.2018.01.003 · Cited by 6
Norman, E. R. V., & Forcht, E. R. (2024) · Journal of School Psychology · doi:10.1016/j.jsp.2024.101319 · Cited by 5
Girdwood, M., Crossley, K. M., Patterson, B., Rio, E., Whitehead, T. S., Morris, H. G., & Culvenor, A. G. (2024) · Scandinavian Journal of Medicine and Science in Sports · doi:10.1111/sms.14727 · Cited by 5
Jensen, C., Sommersten, C. H., Laupsa‐Borge, J., Storås, I., Valeur, J., Mellgren, G., Dierkes, J., Dankel, S. N., & Lied, G. A. (2024) · Clinical Nutrition · doi:10.1016/j.clnu.2024.11.041 · Cited by 5
Wang, X., Mak, W. W. S., Wong, S. Y. S., & Yang, X. (2024) · Computers in Human Behavior · doi:10.1016/j.chb.2024.108551 · Cited by 5
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Kuh, D. J., Ben‐Shlomo, Y., Tilling, K. M., & Hardy, R. (2015) · doi:10.1093/med/9780199661756.003.0123 · Cited by 5
Laupsa‐Borge, J., Grytten, E., Bohov, P., Bjørndal, B., Strand, E., Skorve, J., Nordrehaug, J. E., Berge, R. K., Rostrup, E., Mellgren, G., et al. (2023) · Frontiers in Nutrition · doi:10.3389/fnut.2023.1020678 · Cited by 5
Casey, M. B., Takemasa, S., O'Reilly, T., Leamy, M., Mc Kearney, E., Buckley, M., Smart, K. M., Segurado, R., Lowry, D., Flanagan, D., et al. (2024) · European Journal of Pain · doi:10.1002/ejp.2229 · Cited by 4
Zhang, X., Zhang, M., Lei, N., Ouyang, W., Chen, H.-F., Lao, B., Xu, Y., Tang, F., Fu, L., Liu, X., et al. (2022) · International Urology and Nephrology · doi:10.1007/s11255-022-03390-3 · Cited by 4
Tryggedsson, J. S. J., Andersen, K., Behrendt, S., Bilberg, R., Bogenschutz, M. P., Buehringer, G., & Nielsen, A. S. (2023) · Alcoholism Clinical and Experimental Research · doi:10.1111/acer.15170 · Cited by 4
Fatt, S. J., Hay, P., George, E. S., JEACOCKE, N. A., Rogers, K. D., & Mitchison, D. (2025) · Sports Medicine - Open · doi:10.1186/s40798-025-00927-5 · Cited by 4
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Harrell, F. E. (2015) · Springer series in statistics · doi:10.1007/978-3-319-19425-7_7 · Cited by 4
Fiore, J. F., Shirzadi, S., Roversi, K., Prakash, I., Wong, S. M., Meterissian, S. H., Meguerditchian, A. N., Desbiens, C., Rivard, J., Delisle, M., et al. (2025) · BMJ Open · doi:10.1136/bmjopen-2025-107258 · Cited by 4
Gong, J., Scholes, S., Cole, S., Zaninotto, P., & Steptoe, A. (2025) · Molecular Psychiatry · doi:10.1038/s41380-025-03401-6 · Cited by 4
Wei, X., Yu, H., Dai, W., Huang, L., Liu, Y., Cheng, L., Yang, D. C., Zhang, K., Liao, J. X., Wang, Y., et al. (2026) · Annals of Surgical Oncology · doi:10.1245/s10434-025-18834-0 · Cited by 3
Teunissen, J. S., Griffiths, T. T., van der Heijden, B. E. P. A., Wade, R. G., Lane, J. C. E., Hovius, S. E. R., Bourke, G., Issa, F., Rodrigues, J. N., Harrison, C. J., et al. (2024) · Journal of Hand Surgery (European Volume) · doi:10.1177/17531934241275487 · Cited by 3
Rieveschl, N. B., Song, W., Li, A., Conti, T. F., Hom, G. L., Tsai, G. J., Conti, F. F., Babiuch, A. S., & Singh, R. P. (2020) · Ophthalmic surgery, lasers & imaging retina · doi:10.3928/23258160-20200129-01 · Cited by 3
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Levy, J., Amakiri, U. O., Shammas, R. L., Graziano, F. D., Nelson, J. A., & Boe, L. A. (2025) · Journal of Surgical Oncology · doi:10.1002/jso.70006 · Cited by 2
Schagen, M. R., de Souza, A. A., Boer, K., Krijthe, J. H., Bouamar, R., Stubbs, A., Hesselink, D. A., & de Winter, B. C. M. (2025) · Therapeutic Drug Monitoring · doi:10.1097/ftd.0000000000001359 · Cited by 2
Stapleton, J. R., Ard, J. D., Beavers, D. P., Cogdill, L. S., Fernandez, A., Howard, M. J., Justice, J. N., Lynch, S. D., Newman, J. J., Weaver, A. A., et al. (2023) · Contemporary Clinical Trials Communications · doi:10.1016/j.conctc.2023.101181 · Cited by 2
Schlegl, S., Maier, J., Dieffenbacher, A., & Voderholzer, U. (2023) · European Eating Disorders Review · doi:10.1002/erv.3047 · Cited by 2
Williams, S. A., BATTIN, M. R., Cavadino, A., Mirjalili, A., Pearce, L., Mulqueeney, A., & Stott, N. S. (2025) · Archives of Disease in Childhood Fetal & Neonatal · doi:10.1136/archdischild-2024-328402 · Cited by 2
Wang, Y., Wang, A., Li, Z., Li, Z., Hu, B., Li, X., Zheng, H., Hu, H., Hu, H., Nie, Z., et al. (2020) · Trials · doi:10.1186/s13063-020-04741-0 · Cited by 2
Self-citationLynch, S., Lowry, D., Finnerty, C., O’Meara, Y., & Brennan, D. J. (2023) · Trials · doi:10.1186/s13063-023-07088-4 · Cited by 2
van der Swaluw, K., Lambooij, M., Mathijssen, J. J. P., Schipper, M., Zeelenberg, M., Berkhout, S., Polder, J. J., & Prast, H. M. (2018) · SSRN Electronic Journal · doi:10.2139/ssrn.3122342 · Cited by 1
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Teunissen, J. S., van der Heijden, B., Rodrigues, J. N., Issa, F., & Harrison, C. (2025) · Journal of Plastic Reconstructive & Aesthetic Surgery · doi:10.1016/j.bjps.2025.02.013 · Cited by 1
Hamada, Y., Akasaka, K., Okubo, Y., Hattori, H., Mizoguchi, Y., Kikuchi, Y., Nakagawa, H., & Hall, T. M. (2025) · BMC Sports Science Medicine and Rehabilitation · doi:10.1186/s13102-025-01287-z · Cited by 1
Beisheim, E. H., Mauntel, T. C., Rhon, D. I., Patterson, C. G., Parsons, N., Paradise, S. L., Roach, M. H., Pontillo, M., Gorczynski, S. R., Emory, A., et al. (2025) · Physical Therapy · doi:10.1093/ptj/pzaf138 · Cited by 1
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Zhang, Y., Gu, H., Guo, C., Zheng, H., Gao, X., Wei, X., Liu, C., Cheng, L., Yang, X., Shi, Q., et al. (2025) · Journal of Surgical Research · doi:10.1016/j.jss.2025.10.026 · Cited by 1
Suarez, J. R., Lafontant, K., Banarjee, C., Xie, R., Park, J.-H., & Thiamwong, L. (2026) · Geriatrics · doi:10.3390/geriatrics11010006 · Cited by 1
Registe, P. P. W., Faivre, P., Tanguay, P., Gallant, F., Mekari, S., & Bélanger, M. F. (2026) · Journal of Physical Activity and Health · doi:10.1123/jpah.2025-0617 · Cited by 1
Blom, E., & van Witteloostuijn, M. (2026) · Journal of Experimental Child Psychology · doi:10.1016/j.jecp.2026.106486 · Cited by 1
Bråtveit, M., Laupsa‐Borge, J., Bjørnstad, T., Sommersten, C. H., McCann, A., Lied, G. A., Nygard, O. K., Mellgren, G., Dierkes, J., & Dankel, S. N. (2026) · Journal of Nutrition · doi:10.1016/j.tjnut.2026.101625 · Cited by 1
Aguirre, U., Aróstegui, I., Esteban, C., & Quintana, J. M. (2015) · International Journal of Statistics in Medical Research · doi:10.6000/1929-6029.2015.04.03.1 · Cited by 1
Stomach-Preserving Surgery for Early Gastric Cancer—Reply
Eom, B. W., Han, M., & Yoon, H. (2024) · JAMA Surgery · doi:10.1001/jamasurg.2024.4759 · Cited by 1
He, Y., He, H., Li, H., & Yang, J. (2025) · Journal of Community Psychology · doi:10.1002/jcop.23181 · Cited by 1
Koele, I. J., Blankenstein, N. E., Schreuders, E., van Duijvenvoorde, A. C. K., & Güroğlu, B. (2023) · Research Square · doi:10.21203/rs.3.rs-2653418/v1 · Cited by 1
Valenzuela, P. L., Maffiuletti, N. A., Saner, H. E., Schütz, N., Rudin, B., Nef, T., & Urwyler, P. (2019) · Research Square · doi:10.21203/rs.2.15392/v1 · Cited by 1
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Chakraborty, H. (2013) · Journal of Medical Statistics and Informatics · doi:10.7243/2053-7662-1-2
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Kanwar, N. (2013) · K-State Research Exchange (Kansas State University)
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van Montfort, S. J. T. (2020) · Utrecht University Repository (Utrecht University) · doi:10.33540/253
Moorthy, A., Lowry, D., Edgley, C., Casey, M., & Buggy, D. J. (2021) · Research Square · doi:10.21203/rs.3.rs-892586/v1
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Calvert, C. (2022) · SSRN Electronic Journal · doi:10.2139/ssrn.4142495
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Pielkenrood, B. J. (2022) · doi:10.33540/1391
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Lyimo, E., Makenga, G., Turner, L., Lavstsen, T., Lusingu, J., Geertruyden, J. V., Minja, D. T. R., Wang, C. W., & Baraka, V. (2025) · PLoS ONE · doi:10.1371/journal.pone.0316482
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Wang, Y., Wang, A., Li, H., Li, Z., Hu, B., Li, X., Zheng, H., Fu, L., Hu, H., 聂志余, et al. (2020) · Figshare · doi:10.6084/m9.figshare.13225534
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Chen, Y., Berman, A. H., Andersson, C., Blankers, M., & Molander, O. (2026) · Addiction Science & Clinical Practice · doi:10.1186/s13722-026-00663-5
Endres, A., Heise, M., Arntz, A. R., Faßbinder, E., Schaich, A., Schönauer, M., Werthmann, J., & Renner, F. (2026) · Behaviour Research and Therapy · doi:10.1016/j.brat.2026.105089
Applebaum, A. J., Jacobs, J. M., Fresco, D. M., Hoyt, M. A., Schofield, E., Loschiavo, M. J., O’Toole, M. S., Dunderdale, L., & Mennin, D. S. (2026) · Annals of Behavioral Medicine · doi:10.1093/abm/kaag021
Porras, C. P., Canto, E. D., Handoko, M. L., Haitjema, S., de Groot, M., Bots, M. L., Verhaar, M. C., & Vernooij, R. W. M. (2026) · Journal of the American Heart Association · doi:10.1161/jaha.125.046252
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Anoosha Pai, S., White, M. S., Black, M. S., Young, K. A., Sherman, S. L., Chu, C. R., Williams, A. A., Gold, G. E., Kogan, F., Hargreaves, B. A., et al. (2026) · Journal of Orthopaedic Research® · doi:10.1002/jor.70274
Metadata
- Authors
- Peters, S. A. E., Bots, M. L., den Ruijter, H. M., Palmer, M. K., Grobbee, D. E., Crouse, J. R., O’Leary, D. H., Evans, G. W., Raichlen, J. S., Moons, K. G. M., & Koffijberg, H.
- Affiliations
- University Medical Center Utrecht (NL)
- Keele University (GB)
- Wake Forest University Health Sciences (US)
- Carney Hospital (US)
- Wake Forest University (US)
- AstraZeneca (United States) (US)
- Corresponding author
- Peters, Sanne A.E.
- ORCID
- Venue
- Journal of Clinical Epidemiology
- Publisher
- Elsevier BV
- Published
- 2012-06
- Volume
- 65
- Issue
- 6
- Pages
- 686-695
- ISSN
- 0895-4356 (ISSN-L)
- OpenAlex
- W1981329116
- Cited by
- 165
- References
- 51
- Citations by year
- 2026: 13 · 2025: 13 · 2024: 15 · 2023: 15 · 2022: 20 · 2021: 11 · 2020: 13 · 2019: 7 · 2018: 15 · 2017: 9 · 2016: 7 · 2015: 10 · 2014: 6 · 2013: 7 · 2012: 3
- FWCI
- 7.95
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Journal of Clinical Epidemiology (publishedVersion)
- PubMed (publishedVersion)
- University of Twente Research Information (publishedVersion)
- University of Twente Research Information (submittedVersion)
- Topics
- Physical Sciences › Mathematics › Statistics and Probability › Statistical Methods and Bayesian Inference
- Physical Sciences › Mathematics › Statistics and Probability › Statistical Methods in Clinical Trials
- Physical Sciences › Mathematics › Statistics and Probability › Advanced Causal Inference Techniques
- Keywords
- multiple imputation, linear mixed models, longitudinal data, carotid intima-media thickness, rosuvastatin, treatment effect estimation, bias and precision, missing data handling, confidence interval coverage
- MeSH terms
- Rosuvastatin Calcium, Algorithms, Biometry, Clinical Trials as Topic, Female, Fluorobenzenes, Humans, Longitudinal Studies, Male, Middle Aged, Pyrimidines, Research Design, Sulfonamides, Models, Statistical, Confidence Intervals, Hydroxymethylglutaryl-CoA Reductase Inhibitors, Atherosclerosis, Carotid Intima-Media Thickness
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