Adequate sample size for developing prediction models is not simply related to events per variable

Ogundimu, Emmanuel O.; Altman, Douglas G.; Collins, Gary S.

doi:10.1016/j.jclinepi.2016.02.031

Adequate sample size for developing prediction models is not simply related to events per variable

Objectives The choice of an adequate sample size for a Cox regression analysis is generally based on the rule of thumb derived from simulation studies of a minimum of 10 events per variable (EPV). One simulation study suggested scenarios in which the 10 EPV rule can be relaxed. The effect of a ra…