A survey of experts to identify methods to detect problematic studies: stage 1 of the INveStigating ProblEmatic Clinical Trials in Systematic Reviews project

Wilkinson, Jack; Heal, Calvin; Antoniou, George A.; Flemyng, Ella; Avenell, Alison; Barbour, Virginia; Bordewijk, Esmee M.; Brown, Nicholas J.L.; Clarke, Mike; Dumville, Jo; Grohmann, Steph; Gurrin, Lyle C.; Hayden, Jill A.; Hunter, Kylie E.; Lam, Emily; Lasserson, Toby; Li, Tianjing; Lensen, Sarah; Liu, Jianping; Lundh, Andreas; Meyerowitz-Katz, Gideon; Mol, Ben W.; O'Connell, Neil E.; Parker, Lisa; Redman, Barbara; Seidler, Anna Lene; Sheldrick, Kyle; Sydenham, Emma; Dahly, Darren L.; van Wely, Madelon; Bero, Lisa; Kirkham, Jamie J.

doi:10.1016/j.jclinepi.2024.111512

A survey of experts to identify methods to detect problematic studies: stage 1 of the INveStigating ProblEmatic Clinical Trials in Systematic Reviews project

BACKGROUND Randomised controlled trials (RCTs) inform healthcare decisions. Unfortunately, some published RCTs contain false data, and some appear to have been entirely fabricated. Systematic reviews are performed to identify and synthesise all RCTs which have been conducted on a given topic. Thi…