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Cited by 391

The DOI matches its Crossref record; 30 of the 30 references it cites were found in a registry or an index.

Low to Moderate Dose Anthracycline-Based Chemotherapy Is Associated With Early Noninvasive Imaging Evidence of Subclinical Cardiovascular Disease

Open access
Drafts, Brandon C., Twomley, Katie M., D'Agostino, Ralph, Lawrence, Julia, Avis, Nancy, Ellis, Leslie R., Thohan, Vinay, Jordan, Jennifer, Melin, Susan A., Torti, Frank M., Little, William C., Hamilton, Craig A., Hundley, W. Gregory·2013·JACC: Cardiovascular Imaging
DOI 10.1016/j.jcmg.2012.11.017
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Abstract

Objective To determine if low to moderate doses of anthracycline-based chemotherapy (Anth-bC) are associated with subclinical cardiovascular (CV) injury. Background Cancer survivors that receive Anth-bC experience premature CV events. It is unknown whether low to moderate doses of anthracyclines a) promote early subclinical CV disease manifested by deteriorations in left ventricular ejection fraction (LVEF) or increases in aortic stiffness, or b) are associated with change in quality of life (QOL). Methods In 53 men and women with breast cancer, leukemia, or lymphoma, we assessed left ventricular volumes, LVEF, circumferential strain, aortic pulse wave velocity (PWV), late gadolinium enhancement, serum B-type natriuretic peptide (BNP), troponin I (TnI), and the impact of treatment on QOL before, and 1, 3, and 6 months after receipt of Anth-bC. Results Participants averaged 50±2 (range 19–80) years in age, 58% were women, 17% were black, and they each received a range of 50 to 375 mg/m2 of doxorubicin equivalent chemotherapy. Left ventricular end systolic volume (LVESV; 48±3 to 54±3 ml; p=0.02), left ventricular strain (−17.7±0.4 to −15.1±0.4; p=0.0003), PWV (6.7±0.5 to 10.1±1 m/sec; p=0.0006), and QOL deterioration (15.4±3.3 to 28.5±3.9; p=0.008) increased, while LVEF (58±1 to 53±1%; p=0.0002) decreased within 6 months after low to moderate doses of Anth-bC. All findings persisted after accounting for age, gender, race (white/black), doxorubicin equivalent dose, doxorubicin administration technique, comorbidities associated with CV events, and cancer diagnosis (p=0.02 to 0.0001 for all). There were no new late gadolinium enhancement findings after 6 months. Conclusions Low to moderate doses of Anth-bC are associated with the early development of subclinical abnormalities of cardiac and vascular function that in other populations are associated with the future occurrence of CV events.

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Metadata

Authors
Drafts, B. C., Twomley, K. M., D'Agostino, R., Lawrence, J., Avis, N., Ellis, L. R., Thohan, V., Jordan, J., Melin, S. A., Torti, F. M., Little, W. C., Hamilton, C. A., & Hundley, W. G.
Venue
JACC: Cardiovascular Imaging
Publisher
Elsevier BV
Published
2013-08
Volume
6
Issue
8
Pages
877-885
ISSN
  • 1876-7591 (ISSN-L)
  • 1936-878X
DOI
10.1016/j.jcmg.2012.11.017
OpenAlex
W2087954557
Cited by
391
References
30
FWCI
16.74
Type
journal article
Language
en
Open access
bronze

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CoChat. (2026). Citation check: Low to Moderate Dose Anthracycline-Based Chemotherapy Is Associated With Early Noninvasive Imaging Evidence of Subclinical Cardiovascular Disease. https://app.cochat.ai/papers/10.1016/j.jcmg.2012.11.017
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Drafts, B. C., Twomley, K. M., D'Agostino, R., Lawrence, J., Avis, N., Ellis, L. R., Thohan, V., Jordan, J., Melin, S. A., Torti, F. M., Little, W. C., Hamilton, C. A., & Hundley, W. G. (2013). Low to Moderate Dose Anthracycline-Based Chemotherapy Is Associated With Early Noninvasive Imaging Evidence of Subclinical Cardiovascular Disease. JACC: Cardiovascular Imaging. https://doi.org/10.1016/j.jcmg.2012.11.017

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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).

Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.