The DOI matches its Crossref record; 52 of the 52 references it cites were found in a registry or an index.
Cardiomyopathy With Restrictive Physiology in Sickle Cell Disease
Open accessAbstract
Objectives The aim of this study was to identify a unifying cardiac pathophysiology that explains the cardiac pathological features in sickle cell disease (SCD).Background Cardiopulmonary complications, the leading cause of adult death in SCD, are associated with heart chamber dilation, diastolic dysfunction, elevated tricuspid regurgitant jet velocity (TRV), and pulmonary hypertension. However, no unifying cardiac pathophysiology has been identified to explain these findings.Methods In a 2-part study, we first examined patients with SCD who underwent screening echocardiography during steady state at our institution. We then conducted a meta-analysis of cardiac studies in SCD.Results In the 134 patients with SCD studied (median age 11 years), significant enlargement of the left atrial volume was present (z-score 3.1, p = 0.002), shortening fraction was normal (37.6 ± 4.7%), and lateral and septal ratios of mitral velocity to early diastolic velocity of the mitral annulus (E/e') were severely abnormal in 8% and 14% of patients, respectively, indicating impaired diastolic function. Both TRV and lateral E/e' correlated with enlarged left atrial volume in SCD (p = 0.003 and p = 0.006, respectively). Meta-analysis of 68 studies confirmed significant left atrial diameter enlargement in patients with SCD compared with controls, evidence of diastolic dysfunction and enlarged left ventricular end-diastolic dimension with normal shortening fraction. The majority of patients with catheter-confirmed pulmonary hypertension had mild pulmonary venous hypertension consistent with restrictive cardiac physiology.Conclusions Patients with SCD have a unique form of cardiomyopathy with restrictive physiology that is superimposed on hyperdynamic physiology and is characterized by diastolic dysfunction, left atrial dilation, and normal systolic function. This combination results in mild, secondary, pulmonary venous hypertension and elevated TRV. Sudden death is common in other forms of restrictive cardiomyopathy. Our finding of this unique restrictive cardiomyopathy may explain the increased mortality rates and sudden death seen in patients with SCD with mildly elevated TRV.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
The source backs part of the claim, not all of it — or backs it for a different population, condition or comparison.
In the citing paper
“Recent studies in SCD mice further highlight the importance of diastolic dysfunction in SCD, and myocardial fibrosis is reported to occur both in these mice and in patients (the latter measured by extracellular volume using cardiac MRI imaging) (197–199).”
From Pathophysiology of Sickle Cell Disease (2019) · cites this paper as [198]
Experimental — accuracy not yet measured
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
Meta-analysis in clinical trials
DerSimonian, R., & Laird, N. (1986) · Controlled Clinical Trials · doi:10.1016/0197-2456(86)90046-2 · Cited by 39,552
Quantifying heterogeneity in a meta‐analysis
Higgins, J. P. T., & Thompson, S. G. (2002) · Statistics in Medicine · doi:10.1002/sim.1186 · Cited by 36,763
Recommendations for the Evaluation of Left Ventricular Diastolic Function by Echocardiography
Nagueh, S. F., Appleton, C. P., Gillebert, T. C., Marino, P. N., Oh, J. K., Smiseth, O. A., Waggoner, A. D., Flachskampf, F. A., Pellikka, P. A., & Evangelista, A. (2009) · Journal of the American Society of Echocardiography · doi:10.1016/j.echo.2008.11.023 · Cited by 4,367
Survival in Patients with Primary Pulmonary Hypertension
D’Alonzo, G. E., Barst, R. J., Ayres, S. M., Bergofsky, E. H., Brundage, B. H., Detre, K. M., Fishman, A. P., Goldring, R. M., Groves, B. Μ., Kernis, J. T., et al. (1991) · Annals of Internal Medicine · doi:10.7326/0003-4819-115-5-343 · Cited by 3,488
Recommendations for the evaluation of left ventricular diastolic function by echocardiography
Nagueh, S. F., Appleton, C. P., Gillebert, T. C., Marino, P. N., Oh, J. K., Smiseth, O. A., Waggoner, A. D., Flachskampf, F. A., Pellikka, P. A., & Evangelisa, A. (2008) · European Journal of Echocardiography · doi:10.1093/ejechocard/jep007 · Cited by 3,351
Pulmonary Hypertension as a Risk Factor for Death in Patients with Sickle Cell Disease
Gladwin, M. T., Sachdev, V., Jison, M. L., Shizukuda, Y., Plehn, J. F., Minter, K., Brown, B., Coles, W. A., Nichols, J. S., Ernst, I., et al. (2004) · New England Journal of Medicine · doi:10.1056/nejmoa035477 · Cited by 1,325
Kato, G. J., Gladwin, M. T., & Steinberg, M. H. (2007) · Blood Reviews · doi:10.1016/j.blre.2006.07.001 · Cited by 876
Kašner, M., Westermann, D., Paul Steendijk, A., Gaub, R., Wilkenshoff, U. M., Weitmann, K., Hoffmann, W. U., Poller, W. C., Schultheiss, H., Pauschinger, M., et al. (2007) · Circulation · doi:10.1161/circulationaha.106.661983 · Cited by 564
Outcome of Sickle Cell Anemia: A 4-Decade Observational Study of 1056 Patients
Powars, D. R., Chan, L. S., Hiti, A., Ramicone, E., & Johnson, C. (2005) · Medicine · doi:10.1097/01.md.0000189089.45003.52 · Cited by 558
A Hemodynamic Study of Pulmonary Hypertension in Sickle Cell Disease
Parent, F., Bachir, D., Inamo, J., Lionnet, F., Driss, F., Loko, G., Habibi, A., Bennani, S. L., Savale, L., Adnot, S., et al. (2011) · New England Journal of Medicine · doi:10.1056/nejmoa1005565 · Cited by 511
Cited by
Sorted by citations
Haemodynamic definitions and updated clinical classification of pulmonary hypertension
Simonneau, G., Montani, D., Celermajer, D. S., Denton, C. P., Gatzoulis, M. A., Krowka, M., Williams, P. G., & Souza, R. (2019) · European Respiratory Journal · doi:10.1183/13993003.01913-2018 · Cited by 3,813
Rees, D. C., Williams, T. N., & Gladwin, M. T. (2010) · The Lancet · doi:10.1016/s0140-6736(10)61029-x · Cited by 2,504
Ware, R. E., de Montalembert, M., Tshilolo, L. M., & Abboud, M. R. (2017) · The Lancet · doi:10.1016/s0140-6736(17)30193-9 · Cited by 1,036
Pathophysiology of Sickle Cell Disease
Sundd, P., Gladwin, M. T., & Novelli, E. M. (2019) · Annual Review of Pathology Mechanisms of Disease · doi:10.1146/annurev-pathmechdis-012418-012838 · Cited by 813
Intravascular hemolysis and the pathophysiology of sickle cell disease
Kato, G. J., Steinberg, M. H., & Gladwin, M. T. (2017) · Journal of Clinical Investigation · doi:10.1172/jci89741 · Cited by 748
Quinn, C. T. (2016) · Experimental Biology and Medicine · doi:10.1177/1535370216640385 · Cited by 116
Self-citationAssociation between diffuse myocardial fibrosis and diastolic dysfunction in sickle cell anemia
Niss, O., Fleck, R., Makue, F., Alsaied, T., Desai, P., Towbin, J. A., Malik, P., Taylor, M. D., & Quinn, C. T. (2017) · Blood · doi:10.1182/blood-2017-02-767624 · Cited by 115
Self-citationMcGann, P. T., Niss, O., Dong, M., Marahatta, A., Howard, T. A., Mizuno, T., Lane, A., Kalfa, T. A., Malik, P., Quinn, C. T., et al. (2019) · American Journal of Hematology · doi:10.1002/ajh.25510 · Cited by 105
Self-citationCardiovascular complications of sickle cell disease
Sachdev, V., Rosing, D. R., & Thein, S. L. (2020) · Trends in Cardiovascular Medicine · doi:10.1016/j.tcm.2020.02.002 · Cited by 80
Knowledge insufficient: the management of haemoglobin SC disease
Pecker, L. H., Schaefer, B. A., & Luchtman‐Jones, L. (2016) · British Journal of Haematology · doi:10.1111/bjh.14444 · Cited by 70
Vascular Instability and Neurological Morbidity in Sickle Cell Disease: An Integrative Framework
Stotesbury, H., Kawadler, J. M., Hales, P. W., Saunders, D. E., Clark, C. A., & Kirkham, F. J. (2019) · Frontiers in Neurology · doi:10.3389/fneur.2019.00871 · Cited by 66
Losartan for the nephropathy of sickle cell anemia: A phase‐2, multicenter trial
Quinn, C. T., Saraf, S. L., Gordeuk, V. R., Fitzhugh, C. D., Creary, S. E., Bodas, P., George, A., Raj, A. B., Nero, A. C., Terrell, C. E., et al. (2017) · American Journal of Hematology · doi:10.1002/ajh.24810 · Cited by 57
Self-citationCardiovascular complications in patients with sickle cell disease
Gladwin, M. T. (2017) · Hematology · doi:10.1182/asheducation-2017.1.423 · Cited by 56
Quinn, C. T., Smith, E. P., Arbabi, S., Khera, P. K., Lindsell, C. J., Niss, O., Joiner, C. H., Franco, R. S., & Cohen, R. M. (2016) · American Journal of Hematology · doi:10.1002/ajh.24562 · Cited by 55
Self-citationRuhl, A. P., Sadreameli, S. C., Allen, J. L., Bennett, D. P., Campbell, A., Coates, T. D., Diallo, D. A., Field, J. J., Fiorino, E. K., Gladwin, M. T., et al. (2019) · Annals of the American Thoracic Society · doi:10.1513/annalsats.201906-433st · Cited by 57
Cardiovascular manifestations of sickle cell disease
Hammoudi, N., Lionnet, F., Redheuil, A. B., & Montalescot, G. (2019) · European Heart Journal · doi:10.1093/eurheartj/ehz217 · Cited by 54
Sickle cell disease: at the crossroads of pulmonary hypertension and diastolic heart failure
Wood, K. C., Gladwin, M. T., & Straub, A. C. (2019) · Heart · doi:10.1136/heartjnl-2019-314810 · Cited by 48
IL-18 mediates sickle cell cardiomyopathy and ventricular arrhythmias
Gupta, A., Fei, Y., Kim, T. Y., Xie, A., Batai, K., Greener, I. D., Tang, H., Ciftci-Yilmaz, S., Juneman, E. B., Indik, J. H., et al. (2020) · Blood · doi:10.1182/blood.2020005944 · Cited by 47
Farrell, A. T., Panepinto, J. A., Desai, A. A., Kassim, A. A., Lebensburger, J. D., Walters, M. C., Bauer, D. E., Blaylark, R. M., DiMichele, D., Gladwin, M. T., et al. (2019) · Blood Advances · doi:10.1182/bloodadvances.2019000883 · Cited by 41
Self-citationHoppe, C. C., & Neumayr, L. (2019) · Hematology/Oncology Clinics of North America · doi:10.1016/j.hoc.2019.01.014 · Cited by 38
Omote, K., Nagai, T., Iwano, H., Tsujinaga, S., Kamiya, K., Aikawa, T., Konishi, T., Sato, T., Kato, Y., Komoriyama, H., et al. (2019) · ESC Heart Failure · doi:10.1002/ehf2.12541 · Cited by 35
Rotz, S. J., Ryan, T. D., Hlavaty, J., George, S. A., El-Bietar, J. A., & Dandoy, C. E. (2017) · Pediatric Blood & Cancer · doi:10.1002/pbc.26600 · Cited by 31
Clinical Features of β-Thalassemia and Sickle Cell Disease
McGann, P. T., Nero, A. C., & Ware, R. E. (2017) · Advances in experimental medicine and biology · doi:10.1007/978-1-4939-7299-9_1 · Cited by 29
Hemopexin dosing improves cardiopulmonary dysfunction in murine sickle cell disease
Buehler, P. W., Swindle, D. C., Pak, D. I., Ferguson, S. K., Majka, S. M., Karoor, V., Moldovan, R., Sintas, C., Black, J., Gentinetta, T., et al. (2021) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2021.08.238 · Cited by 29
Szafraniec, H. M., Valdez, J. M., Iffrig, E., Lam, W. A., Higgins, J. M., Pearce, P., & Wood, D. K. (2022) · Lab on a Chip · doi:10.1039/d1lc01133b · Cited by 28
Dhar, A., Leung, T. M., Appiah‐Kubi, A., Gruber, D., Aygün, B., Serigano, O., & Mitchell, E. (2021) · Blood Advances · doi:10.1182/bloodadvances.2021005076 · Cited by 26
Diastolic dysfunction is associated with exercise impairment in patients with sickle cell anemia
Alsaied, T., Niss, O., Powell, A. W., Fleck, R. J., Cnota, J. F., Chin, C. C., Malik, P., Quinn, C. T., & Taylor, M. D. (2018) · Pediatric Blood & Cancer · doi:10.1002/pbc.27113 · Cited by 26
Self-citationAlsaied, T., Niss, O., Tretter, J. T., Powell, A. W., Chin, C. C., Fleck, R. J., Cnota, J. F., Malik, P., Quinn, C. T., Nagueh, S. F., et al. (2020) · Scientific Reports · doi:10.1038/s41598-020-58662-8 · Cited by 24
Self-citationGenomic Insights into Cardiomyopathies: A Comparative Cross-Species Review
Simpson, S., Rutland, P., & Rutland, C. S. (2017) · Veterinary Sciences · doi:10.3390/vetsci4010019 · Cited by 24
Niss, O., Detterich, J. A., Wood, J. C., Coates, T. D., Malik, P., Taylor, M. D., & Quinn, C. T. (2022) · Blood · doi:10.1182/blood.2021015303 · Cited by 23
Self-citationThe Cardiopulmonary Complications of Sickle Cell Disease
Desai, A. A., Machado, R. F., & Cohen, R. T. (2022) · Hematology/Oncology Clinics of North America · doi:10.1016/j.hoc.2022.07.014 · Cited by 24
Coronary arterial vasculature in the pathophysiology of hypertrophic cardiomyopathy
Marszalek, R. J., Solaro, R. J., & Wolska, B. M. (2018) · Pflügers Archiv - European Journal of Physiology · doi:10.1007/s00424-018-2224-y · Cited by 20
Epidemiology, Pathogenesis, and Clinical Approach in Group 5 Pulmonary Hypertension
Al‐Qadi, M. O., LeVarge, B. L., & Ford, H. J. (2021) · Frontiers in Medicine · doi:10.3389/fmed.2020.616720 · Cited by 21
Nutritional Heart Disease and Cardiomyopathies
Sliwa, K. S., Viljoen, C. A., Hasan, B. S., & Ntusi, N. (2023) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2022.08.812 · Cited by 20
d’Humières, T., Savale, L., Inamo, J., Deux, J., Deswarte, S., Lionnet, F., Loko, G., Chantalat, C., Damy, T., Guillet, H., et al. (2021) · American Journal of Hematology · doi:10.1002/ajh.26271 · Cited by 19
Manifestations of sickle cell disease on thoracic imaging
Wang, M. X., Pepin, E. W., Verma, N., & Mohammed, T.-L. H. (2017) · Clinical Imaging · doi:10.1016/j.clinimag.2017.09.001 · Cited by 17
Ventricular global longitudinal strain is altered in children with sickle cell disease
Whipple, N. S., Naik, R., Kang, G., Moen, J., Govindaswamy, S. D., Fowler, J. A., Dowdy, J., Penkert, R. R., Joshi, V. M., & Hankins, J. S. (2018) · British Journal of Haematology · doi:10.1111/bjh.15607 · Cited by 16
Yates, A. M., Joshi, V. M., Aygün, B., Moen, J., Smeltzer, M. P., Govindaswamy, D., Dowdy, J., Cotton, A., Kang, G., Ware, R. E., et al. (2019) · Pediatric Blood & Cancer · doi:10.1002/pbc.27717 · Cited by 16
High-Output Heart Failure in Sickle Cell Anemia
Reddy, Y. N. V., & Borlaug, B. A. (2016) · JACC. Cardiovascular imaging · doi:10.1016/j.jcmg.2016.04.004 · Cited by 16
Gbotosho, O. T., Gollamudi, J., & Hyacinth, H. I. (2023) · Biomolecules · doi:10.3390/biom13020381 · Cited by 15
Evolution of echocardiography in subclinical detection of cancer therapy–related cardiac dysfunction
Moudgil, R., Hassan, S. A., Palaskas, N. L., Lopez‐Mattei, J., Banchs, J. A., & Yusuf, S. W. (2018) · Echocardiography · doi:10.1111/echo.14012 · Cited by 13
d’Humières, T., Saba, J., Savale, L., Dupuy, M., Boyer, L., Guillet, H., Alassaad, L., Luna, G. D., Iles, S., D'Orengiani, A.-L. P. H. D., et al. (2023) · Blood · doi:10.1182/blood.2022019571 · Cited by 13
A reappraisal of the mechanisms underlying the cardiac complications of sickle cell anemia
Rai, P., Niss, O., & Malik, P. (2017) · Pediatric Blood & Cancer · doi:10.1002/pbc.26607 · Cited by 13
Self-citationClinical Manifestations of Sickle Cell Disease Across the Lifespan
Pecker, L. H., & Little, J. A. (2017) · Springer eBooks · doi:10.1007/978-3-319-62328-3_1 · Cited by 14
Echocardiographic parameters to identify sickle cell patients with cardio‐pathology
Chiadika, S. M., Lim‐Fung, M., Llanos‐Chea, F., Canache, A. S., Yang, W., Paruthi, C., Zhang, X., McPherson, D. D., & Idowu, M. (2018) · Echocardiography · doi:10.1111/echo.14028 · Cited by 12
Clinical relevance of pulmonary vasculature involvement in sickle cell disease
Carstens, G. R., de Araújo-Paulino, B. B., Katayama, E. H., Amato‐Lourenço, L. F., Fonsêca, G. H. H., Souza, R., Aiello, V. D., & Mauad, T. (2019) · British Journal of Haematology · doi:10.1111/bjh.15795 · Cited by 12
Sleep and the Cardiovascular System in Children
Paul, G., & Pinto, S. J. (2017) · Sleep Medicine Clinics · doi:10.1016/j.jsmc.2017.01.004 · Cited by 12
Pediatric Cardio-Oncology Medicine: A New Approach in Cardiovascular Care
Martinez, H. R., Beasley, G. S., Goldberg, J. F., Absi, M. A., Ryan, K. A., Guerrier, K., Joshi, V. M., Johnson, J. N., Morin, C. E., Hurley, C., et al. (2021) · Children · doi:10.3390/children8121200 · Cited by 11
Self-citationApplications of cardiac magnetic resonance imaging in sickle cell disease
Niss, O., & Taylor, M. D. (2017) · Blood Cells Molecules and Diseases · doi:10.1016/j.bcmd.2017.08.005 · Cited by 10
Self-citationOptimizing Hydroxyurea Treatment for Sickle Cell Disease Patients: The Pharmacokinetic Approach
Nazon, C., Sabo, A.-N., Becker, G., Lessinger, J., Kemmel, V., & Paillard, C. (2019) · Journal of Clinical Medicine · doi:10.3390/jcm8101701 · Cited by 11
Hambley, B. C., Rahman, R. A., Reback, M. A., O’Riordan, M. A., Langer, N., Gilkeson, R., Ginwalla, M. B., Little, J. A., & Schilz, R. J. (2018) · Haematologica · doi:10.3324/haematol.2018.196212 · Cited by 11
Chatzidavid, S., Flevari, P., Tombrou, I., Anastasiadis, G., & Dimopoulou, M. (2024) · International Journal of Molecular Sciences · doi:10.3390/ijms25094792 · Cited by 10
Díaz-Matallana, M., Márquez-Benítez, Y., Martínez, J., Briceño, I., Benavides, E., & Bernal, J. E. (2021) · Revista médica de Chile · doi:10.4067/s0034-98872021000901322 · Cited by 16
Hakami, F., Alhazmi, E. A., Busayli, W. M., Althurwi, S., Darraj, A. M., Alamir, M. A., Hakami, A., Othman, R. A., Moafa, A. I., Mahasi, H. A., et al. (2023) · Cureus · doi:10.7759/cureus.50577 · Cited by 10
Cardiomyopathy in Sickle Cell Disease
Kaur, H., Aurif, F., Kittaneh, M., Chio, J. P. G., & Malik, B. H. (2020) · Cureus · doi:10.7759/cureus.9619 · Cited by 10
Cramer‐Bour, C., Ruhl, A. P., Nouraie, M. S., Emeh, R. O., Ruopp, N. F., Thein, S. L., Weir, N. A., & Klings, E. S. (2021) · European Journal Of Haematology · doi:10.1111/ejh.13612 · Cited by 11
Sickle cell disease and ventricular myocardial strain: A systematic review
Whipple, N. S., Joshi, V. M., Naik, R., Mentnech, T., McFarland, M., Nolan, V. G., & Hankins, J. S. (2021) · Pediatric Blood & Cancer · doi:10.1002/pbc.28973 · Cited by 10
Echocardiographic Evaluation in Paediatric Sickle Cell Disease Patients: A Pilot Study
Sabatini, L., Chinali, M., Franceschini, A., Mauro, M. D., Marchesani, S., Fini, F., Arcuri, G., Lodi, M., Palumbo, G. A., & Ceglie, G. (2022) · Journal of Clinical Medicine · doi:10.3390/jcm12010007 · Cited by 9
Progress in Cardiovascular Imaging
Shaw, L. J., & Chandrashekhar, Y. (2019) · JACC. Cardiovascular imaging · doi:10.1016/j.jcmg.2019.11.002 · Cited by 9
d’Humières, T., Bouvarel, A., Boyer, L., Savale, L., Guillet, H., Alassaad, L., Luna, G. D., Berti, E., Iles, S., D'Orengiani, A.-L. P. H. D., et al. (2024) · Scientific Reports · doi:10.1038/s41598-024-61689-w · Cited by 8
Cardiovascular consequences of sickle cell disease
Palomarez, A., Jha, M., Romero, X. M., & Horton, R. E. (2022) · Biophysics Reviews · doi:10.1063/5.0094650 · Cited by 10
Rai, P., Okhomina, V. I., Kang, G., Martinez, H. R., Hankins, J. S., & Joshi, V. M. (2023) · American Journal of Hematology · doi:10.1002/ajh.26911 · Cited by 8
Effect of voxelotor on cardiopulmonary testing in youths with sickle cell anemia in a pilot study
Phan, V., Hershenson, J. A., Caldarera, L. L., Larkin, S. K., Wheeler, K., Cortez, A. L., Dulman, R. Y., Briere, N., Lewis, A., Kuypers, F. A., et al. (2023) · Pediatric Blood & Cancer · doi:10.1002/pbc.30423 · Cited by 8
Wagdy, R. M., Fathy, A., Elnekidy, A., Salaheldin, G., Nazir, H. F., Fahmy, R., Elkafrawy, H., & Elkafrawy, F. R. (2023) · Pediatric Radiology · doi:10.1007/s00247-023-05750-2 · Cited by 7
17(R)-Resolvin D1 protects against sickle cell–related inflammatory cardiomyopathy in humanized mice
Federti, E., Mattoscio, D., Recchiuti, A., Mattè, A., Monti, M., Cozzolino, F., Iezzi, M., Ceci, M., Ghigo, A., Tolosano, E., et al. (2025) · Blood · doi:10.1182/blood.2024024768 · Cited by 7
Cardiac pathophysiology in sickle cell disease
Gbotosho, O. T., Taylor, M. D., & Malik, P. (2021) · Journal of Thrombosis and Thrombolysis · doi:10.1007/s11239-021-02414-6 · Cited by 8
Self-citationMorin, C. E., Sharma, A., Selukar, S., Beasley, G. S., Merlocco, A. C., Goode, C. G., Rai, P., Towbin, J. A., Hankins, J. S., & Johnson, J. N. (2022) · Blood · doi:10.1182/blood.2022018209 · Cited by 7
Self-citationIn-hospital Outcomes and Characteristics of Heart Failure in Sickle Cell Disease
Fadiran, O., Balogun, A. F., Ogunti, R., Buhari, O., Lanka, C., Atanda, A. C., Larbi, D. A., & Mehrotra, P. P. (2019) · Cureus · doi:10.7759/cureus.5660 · Cited by 7
Simon, T., Savale, L., Skaarup, K. G., Breillat, P., Pham, L., Nouraie, M. S., Johansen, N. D., Inamo, J., Lionnet, F., Loko, G., et al. (2025) · American Journal of Hematology · doi:10.1002/ajh.27768 · Cited by 6
Galadanci, N. A., Johnson, W. H., Carson, A. P., Hellemann, G., Howard, V. J., & Kanter, J. (2022) · Haematologica · doi:10.3324/haematol.2021.280480 · Cited by 6
Lilje, C., Harry, J., Gajewski, K. K., & Gardner, R. V. (2017) · Pediatric Blood & Cancer · doi:10.1002/pbc.26606 · Cited by 6
Morrison, M. L., McMahon, C., Tully, R., Enright, N., Pignatelli, R. H., Towbin, J. A., & McMahon, C. J. (2018) · Congenital Heart Disease · doi:10.1111/chd.12592 · Cited by 6
Self-citationImaging review of sickle cell disease for the emergency radiologist
Gilyard, S. N., Hamlin, S. L., Johnson, J.-O., & Herr, K. D. (2020) · Emergency Radiology · doi:10.1007/s10140-020-01828-8 · Cited by 6
Wang, Y., Zhang, L., Liu, S., Li, G., Kong, F., Zhao, C., Yang, J., & Ma, C. (2021) · BMC Cardiovascular Disorders · doi:10.1186/s12872-021-01920-y · Cited by 6
Adeniyi, A. T., Okeniyi, J., Adegoke, S. A., Oseni, S. B. A., Smith, O. S., & Abe-Dada, A. A. (2021) · Journal of Pediatric Hematology/Oncology · doi:10.1097/mph.0000000000002230 · Cited by 6
Limerick, E. M., Shmukler, J., Sirajuddin, A., Nguyen, M., Jeffries, N. O., Sachdev, V., & Fitzhugh, C. D. (2023) · Transplantation and Cellular Therapy · doi:10.1016/j.jtct.2023.11.007 · Cited by 5
Exercise‐induced changes of vital signs in adults with sickle cell disease
Johnson, S., Gordeuk, V. R., Machado, R. F., Gibbs, J. S. R., Hildesheim, M. E., Little, J. A., Kato, G. J., Gladwin, M. T., & Nouraie, M. S. (2021) · American Journal of Hematology · doi:10.1002/ajh.26369 · Cited by 5
Dabirian, M., Janbabaei, G., Karami, H., Nabati, M., Aarabi, M., Namazi, M., & Darvishi‐Khezri, H. (2017) · Acta Informatica Medica · doi:10.5455/aim.2017.25.9-13 · Cited by 5
Diffuse myocardial fibrosis as an SCD biomarker
Thein, S. L., & Sachdev, V. (2022) · Blood · doi:10.1182/blood.2022017725 · Cited by 5
Diretriz Brasileira de Ergometria em Crianças e Adolescentes – 2024
de Carvalho, T., de Freitas, O. G. A., Chalela, W. A., Hossri, C. A. C., Milani, M., Buglia, S., Falcão, A. M. G. M., Costa, R. V. C., Ritt, L. E. F., Pfeiffer, M. E. T., et al. (2024) · Arquivos Brasileiros de Cardiologia · doi:10.36660/abc.20240525 · Cited by 4
Marshall, W. H., Cleary, E. M., Della‐Moretta, S., Li, R., Samuels, P., Desai, P. C., & Rajpal, S. (2022) · British Journal of Haematology · doi:10.1111/bjh.18160 · Cited by 4
Progress in Cardiovascular Imaging
Kramer, C. K., Shaw, L. J., & Chandrashekhar, Y. (2018) · JACC. Cardiovascular imaging · doi:10.1016/j.jcmg.2018.10.014 · Cited by 4
Swarray‐Deen, A., Adana, M. Y., Alao, M. A., Agyen-Frimpong, V. A., Fakunle, A. G., Alangea, D. O., Adjei, D. N., Yeboah, K., Raji, Y. R., Oppong, S. A., et al. (2024) · AJOG Global Reports · doi:10.1016/j.xagr.2024.100413 · Cited by 3
Resende, M. B. S., Ferrari, T. C. A., de Araújo, C. G., Vasconcelos, M. C. M., Tupinambás, J. T., Dias, R. C. T. M., Barros, F. C., Januário, J. N., Barbosa, M. M., & Nunes, M. C. P. (2020) · International journal of cardiac imaging · doi:10.1007/s10554-020-01924-3 · Cited by 3
Albinni, S., Marx, M., & Lang, I. M. (2020) · Medicina · doi:10.3390/medicina56090420 · Cited by 3
Cardiovascular complications of sickle cell disease: A primer for the general clinician
Ilonze, C., Echefu, G. C., Broadnax, A., Johnson, A. E., Etuk, A., & Ilonze, O. J. (2023) · Journal of the National Medical Association · doi:10.1016/j.jnma.2023.11.010 · Cited by 3
Roger, G., Denormandie, P., Gobé, T., Azzolina, D., Pham, T. O., Chantalat, C., Cuveillier, D., Bouchachi, A., Patrick Jourdain, M., Lai, C., et al. (2024) · British Journal of Haematology · doi:10.1111/bjh.19394 · Cited by 3
Brazilian Guideline for Exercise Testing in Children and Adolescents – 2024
de Carvalho, T., de Freitas, O. G. A., Chalela, W. A., Hossri, C. A. C., Milani, M., Buglia, S., Falcão, A. M. G. M., Costa, R. V. C., Ritt, L. E. F., Pfeiffer, M. E. T., et al. (2024) · Arquivos Brasileiros de Cardiologia · doi:10.36660/abc.20240525i · Cited by 3
Cardiopulmonary changes in patients with sickle cell anemia: A systematic review
Lopes, J. S., Viana, Í. G., Santos, M. L. C., de Melo, F. F., Oliveira, M. V., & Souza, C. L. (2022) · World Journal of Hematology · doi:10.5315/wjh.v9.i3.20 · Cited by 2
Ghazaiean, M., Darvishi‐Khezri, H., Najafi, B., Karami, H., & Kosaryan, M. (2025) · PLoS ONE · doi:10.1371/journal.pone.0318751 · Cited by 3
Longitudinal changes and predictors of cardiac extracellular volume fraction in sickle cell anemia
Niss, O., Morin, C. E., Hashemi, S., Alsaied, T., Lang, S. M., Taylor, M. D., Tasset, M., Malik, P., & Quinn, C. T. (2025) · Blood Red Cells & Iron · doi:10.1016/j.brci.2025.100031 · Cited by 3
Self-citationBradach, D., Calderón-Salavarría, K., Diaz‐Arribasplata, S., Almahdi, R. S. I., Mavus, N. B., Sangaraju, S. L., Sam, A. A., Mohamed, M. S., Brutus, C., Poojary, P. S., et al. (2026) · European Journal Of Haematology · doi:10.1111/ejh.70206 · Cited by 2
Simonson, J. L., Pandya, D., Kang, J., Talwar, A., & Zaidi, G. Z. (2021) · Pulmonary Circulation · doi:10.1177/20458940211018345 · Cited by 2
Giray, D., Ünal, S., Demetgül, H., Karpuz, D., & Hallıoğlu, O. (2022) · Journal of diagnostic medical sonography · doi:10.1177/87564793221138581 · Cited by 2
Adeniyi, A. T., Adegoke, S. A., Olatunya, O. S., Babatola, A. O., Ajite, A. B., Ogundare, E. O., Oluwayemi, I. O., Abe-Dada, A. A., & Okeniyi, J. (2023) · Ghana Medical Journal · doi:10.4314/gmj.v57i3.4 · Cited by 2
Haemoglobinopathies from the cardiac point of view
Romano, M. M. D. (2019) · Hematology Transfusion and Cell Therapy · doi:10.1016/j.htct.2019.05.002 · Cited by 2
Jhaveri, S., Choueiter, N. F., Manwani, D. G., Ranabothu, S., Morrone, K. A., Hafeman, M., Reidy, K. J., Kaskel, F. J., & Mahgerefteh, J. (2021) · Journal of Pediatric Hematology/Oncology · doi:10.1097/mph.0000000000002104 · Cited by 2
Cardiovascular Sequelae of Sickle Cell Disease
Aujla, A. S., Dutta, D., Amar, S., Frishman, W. H., & Lim, S. H. (2019) · Cardiology in Review · doi:10.1097/crd.0000000000000264 · Cited by 2
Caughey, M. C., Ataga, K. I., & Hinderliter, A. L. (2016) · JACC. Cardiovascular imaging · doi:10.1016/j.jcmg.2015.06.024 · Cited by 2
Imaging and the Valley of Death
Marwick, T. H., Chandrashekhar, Y., & Narula, J. (2016) · JACC. Cardiovascular imaging · doi:10.1016/j.jcmg.2016.01.008 · Cited by 2
Metadata
- Authors
- Niss, O., Quinn, C. T., Lane, A., Daily, J., Khoury, P. R., Bakeer, N., Kimball, T. R., Towbin, J. A., Malik, P., & Taylor, M. D.
- Affiliations
- Cincinnati Children's Hospital Medical Center (US)
- Corresponding author
- Niss, Omar
- ORCID
- Venue
- JACC: Cardiovascular Imaging
- Publisher
- Elsevier BV
- Published
- 2016-03
- Volume
- 9
- Issue
- 3
- Pages
- 243-252
- ISSN
- 1876-7591 (ISSN-L)
- 1936-878X
- PMC
- PMC4788530
- OpenAlex
- W2276952480
- Cited by
- 142
- References
- 52
- Citations by year
- 2026: 12 · 2025: 9 · 2024: 10 · 2023: 15 · 2022: 16 · 2021: 15 · 2020: 10 · 2019: 20 · 2018: 10 · 2017: 15 · 2016: 9
- FWCI
- 2.10
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- JACC. Cardiovascular imaging (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Funders
- Amgen
- Eli Lilly and Company
- National Institutes of Health (5u01hl117709-05, UL1TR001425)
- National Heart, Lung, and Blood Institute (U01-HL117709, UO1-HL117709, R01HL112603)
- National Center for Advancing Translational Sciences
- Topics
- Health Sciences › Medicine › Genetics (clinical) › Hemoglobinopathies and Related Disorders
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiovascular Function and Risk Factors
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiomyopathy and Myosin Studies
- Keywords
- sickle cell disease, restrictive cardiomyopathy, diastolic dysfunction, left atrial enlargement, tricuspid regurgitation velocity, pulmonary venous hypertension, pulmonary hypertension, left ventricular end-diastolic diameter, sudden death, cardiac pathophysiology
- MeSH terms
- Adolescent, Anemia, Sickle Cell, Child, Female, Humans, Hypertension, Pulmonary, Male, Cardiomyopathies, Predictive Value of Tests, Prognosis, Pulmonary Veins, Retrospective Studies, Risk Factors, Tricuspid Valve, Venous Pressure, Echocardiography, Doppler, Ventricular Function, Right, Atrial Function, Left, Hypertrophy, Left Ventricular, Ventricular Dysfunction, Left, Arterial Pressure
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
