Role of the endocannabinoid system in the regulation of intestinal homeostasis
Open accessAbstract
The endocannabinoid system is a lipid mediator signaling system widely distributed throughout the gastrointestinal tract.The endocannabinoid system plays a pivotal role in the maintenance of intestinal homeostasis and gut barrier integrity, responding to internal and external environmental factors while also serving as a homeostatic effector system.The maintenance of intestinal homeostasis is fundamentally important to health.Intestinal barrier function and immune regulation are key determinants of intestinal homeostasis and are therefore tightly regulated by a variety of signaling mechanisms.The endocannabinoid system is a lipid mediator signaling system widely expressed in the gastrointestinal tract.Accumulating evidence suggests the endocannabinoid system is a critical nexus involved in the physiological processes that underlie the control of intestinal homeostasis.In this review we will illustrate how the endocannabinoid system is involved in regulation of intestinal permeability, fluid secretion, and immune regulation.We will also demonstrate a reciprocal regulation between the endocannabinoid system and the gut microbiome.The role of the endocannabinoid system is complex and multifaceted, responding to both internal and external factors while also serving as an effector system for the maintenance of intestinal homeostasis.(
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The ECS and GM interact to regulate intestinal homeostasis with functional effects in the gut and CNS.
“The ECS and GM interact to regulate intestinal homeostasis resulting in relevant functional effects in the gut and CNS (238, 246, 248, 250).”
From Signalling cognition: The gut microbiota and hypothalamic-pituitary-adrenal axis (2023) · cites this paper as [248]
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References 164 · Cited by 79
Research works printed but not linked: 1
- [159]Muccioli G.G. Naslain D. Bäckhed F. Reigstad C.S. Lambert D.M. Delzenne N.M. Cani P.D. The endocannabinoid system links gut microbiota to adipogenesis Mol Syst Biol 6 2010 392 20664638 PMC2925525
- Authors
- Cuddihey, H., MacNaughton, W. K., & Sharkey, K. A.
- Affiliations
- University of Calgary (CA)
- Corresponding author
- Sharkey, Keith A.
- Venue
- Cellular and Molecular Gastroenterology and Hepatology
- Publisher
- Elsevier BV
- Published
- 2022
- Volume
- 14
- Issue
- 4
- Pages
- 947-963
- ISSN
- 2352-345X (ISSN-L)
- PMC
- PMC9500439
- OpenAlex
- W4283274944
- Cited by
- 79
- References
- 164
- Citations by year
- 2026: 15 · 2025: 23 · 2024: 30 · 2023: 10 · 2022: 1
- FWCI
- 2.29
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- Locations
- Cellular and Molecular Gastroenterology and Hepatology (publishedVersion, cc-by-nc-nd)
- PubMed Central (publishedVersion, cc-by-nc-nd)
- PubMed (publishedVersion)
- Funders
- Canadian Institutes of Health Research (FDN148380, PJT153290)
- Natural Sciences and Engineering Research Council of Canada (RGPIN/04321-2018)
- Topics
- Health Sciences › Medicine › Pharmacology › Cannabis and Cannabinoid Research
- Health Sciences › Medicine › Gastroenterology › Gastrointestinal motility and disorders
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
- Keywords
- endocannabinoid system, intestinal homeostasis, intestinal barrier function, intestinal permeability, intestinal secretion, intestinal immunity, gut microbiota, gastrointestinal tract
- MeSH terms
- Homeostasis, Intestines, Signal Transduction, Gastrointestinal Tract, Endocannabinoids
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