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Cited by 63Advancements in Transdermal Drug DeliveryAdvanced Drug Delivery SystemsPhotodynamic Therapy Research Studies

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Transdermal delivery from a lipid sponge phase—iontophoretic and passive transport in vitro of 5-aminolevulinic acid and its methyl ester

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Merclin, N., Bender, J., Sparr, E., Guy, R.H., Ehrsson, H., Engström, S.·2004·Journal of Controlled Release
DOI 10.1016/j.jconrel.2004.08.025
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Abstract

The hydrochloride salts of 5-aminolevulinic acid (ALA) and its methyl ester (m-ALA), respectively, were dissolved in a lipid sponge phase comprising monoolein, propylene glycol and aqueous buffer at concentrations of approximately 0.25% and 16% w/w m-ALA. The iontophoretic and passive delivery of ALA and m-ALA from this formulation through porcine skin in vitro were measured and compared to formulations used in clinical practice, 20% w/w ALA in Unguentum M and Metvix (a cream containing 16% w/w m-ALA). A sponge phase with 16% w/w m-ALA showed a higher passive flux (approximately 140 nmol cm(-2) h(-1) at 5 h) but a lower iontophoretic flux (approximately 800 nmol cm(-2) h(-1) at 5 h) compared to the clinically used products but the differences are hardly significant due to large standard deviations. ALA and m-ALA in sponge phase formulation showed iontophoretic fluxes in the range 80-100 nmol cm(-2) h(-1) at 3 h, i.e. values comparable to the passive fluxes from the more concentrated vehicles. The results demonstrate that the lipid sponge phase, a thermodynamically stable liquid with amphiphilic character, may have potential as a transdermal drug delivery vehicle.

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References 24 · Cited by 63

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Metadata

Authors
Merclin, N., Bender, J., Sparr, E., Guy, R. H., Ehrsson, H., & Engström, S.
Affiliations
  • Uppsala University (SE)
  • Chalmers University of Technology (SE)
  • Lund University (SE)
  • University of Geneva (CH)
  • Karolinska Institutet (SE)
Corresponding author
Bender, J.
ORCID
Venue
Journal of Controlled Release
Publisher
Elsevier BV
Published
2004-11
Volume
100
Issue
2
Pages
191-198
ISSN
0168-3659 (ISSN-L)
DOI
10.1016/j.jconrel.2004.08.025
OpenAlex
W1975136860
Cited by
63
References
24
Citations by year
2022: 3 · 2021: 1 · 2020: 2 · 2019: 5 · 2017: 4 · 2016: 4 · 2015: 1 · 2014: 2 · 2013: 2 · 2012: 5
FWCI
2.39
Type
journal article
Language
en
Open access
Licence
Locations
  • Journal of Controlled Release (publishedVersion)
  • PubMed (publishedVersion)
  • Archive ouverte UNIGE (University of Geneva) (submittedVersion, cc-by)
  • Lund University Publications (Lund University) (submittedVersion)
  • Chalmers Publication Library (Chalmers University of Technology) (submittedVersion)
  • Chalmers Research (Chalmers University of Technology) (submittedVersion)
Funders
VINNOVA
Topics
  • Life Sciences › Pharmacology, Toxicology and Pharmaceutics › Pharmaceutical Science › Advancements in Transdermal Drug Delivery
  • Life Sciences › Pharmacology, Toxicology and Pharmaceutics › Pharmaceutical Science › Advanced Drug Delivery Systems
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › Photodynamic Therapy Research Studies
Keywords
5-aminolevulinic acid, transdermal drug delivery, iontophoresis, porcine skin, monoolein, propylene glycol, topical formulation, photodynamic therapy
MeSH terms
Administration, Cutaneous, Aminolevulinic Acid, Animals, Biological Transport, Buffers, Ear, External, Excipients, Iontophoresis, Liposomes, Skin, Solutions, Spectrophotometry, Ultraviolet, Swine, Diffusion Chambers, Culture, In Vitro Techniques

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CoChat. (2026). Citation check: Transdermal delivery from a lipid sponge phase—iontophoretic and passive transport in vitro of 5-aminolevulinic acid and its methyl ester. https://app.cochat.ai/papers/10.1016/j.jconrel.2004.08.025
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Merclin, N., Bender, J., Sparr, E., Guy, R. H., Ehrsson, H., & Engström, S. (2004). Transdermal delivery from a lipid sponge phase—iontophoretic and passive transport in vitro of 5-aminolevulinic acid and its methyl ester. Journal of Controlled Release. https://doi.org/10.1016/j.jconrel.2004.08.025