Cationic lipid saturation influences intracellular delivery of encapsulated nucleic acids

Heyes, James, Palmer, Lorne, Bremner, Kaz, MacLachlan, Ian·2005·Journal of Controlled Release
DOI 10.1016/j.jconrel.2005.06.014

Cited by (571)

Items 501–571 of 571

  1. Engineered Silyl Lipids to Modulate Liposome and Lipid Nanoparticle Properties for mRNA Delivery
    Leah A. Patterson, David A. Coppage, Sydney M. Figueroa, Angel A. Cobo, Henriette O’Geen, David Jay Segal, Annaliese K. Franz · 2025 · ACS Applied Bio Materials
  2. Intratracheal administration: Non-invasive approach for liver-targeted siRNA-LNP delivery
    Yan Zong, Lingwei Meng, Xiaoxia Wang, Lili Du, Shuquan Zheng, Hongyan Zhang, Tuo Wei, Shan Gao, Qiang Cheng · 2025 · Nano Research
  3. Effect of ionizable lipid head and tail group modification on mRNA delivery efficiency
    Soan Park, Kanghun Lee, Hyun-Jung An, Enhui Lin, Sugyeom Kim, Hyeongseok Kim, Siheon Jeong, Snehagni Roy, Yeon Woo Kang, Jaehyuk Yang et al. · 2026 · Journal of Drug Delivery Science and Technology
  4. Lipid Nanoparticles for Drug Delivery
    You Zhou, Ruchao Jiang, Wenjie Chen · 2026 · Elsevier eBooks
  5. Ionizable lipids as a promising platform for creating mRNA vaccines
    Svetlana V. Milagina, Pavel A. Puchkov · 2026 · Fine Chemical Technologies
  6. Tandem and mild synthesis of a symmetric secondary alcohol toward an ionizable lipid analogue of DLin-MC3-DMA
    Siyu Pan, Demeng Liu, Delong Hou, Qi Zeng, Jierui Yan, Yi Chen · 2026 · Green Chemistry
  7. Mechanistic Insight Into Ionizable Cationic Lipid‐Mediated Endosomal Escape via Transient Lipid Complexes
    David Noel Zimmer, Friederike Schmid, Giovanni Settanni · 2026 · Small
  8. Nano‐Enabled Toxicity of Pharmaceutical Excipients
    Ilaria Polidori, Lena Werner, Andreas Bernkop‐Schnürch · 2026 · Wiley Interdisciplinary Reviews Nanomedicine and Nanobiotechnology
  9. Bisaminoquinoline-bridged lipid for potent mRNA vaccine delivery and anti-tumor immunity
    Yanru Feng, Shiyang Xin, Lu Huang, Y L Li, Meng Yan, Kexin Cong, Chaoxing He, Haitao Shen, Zhao Ma, L Wang et al. · 2026 · Chinese Chemical Letters
  10. Membrane environment sets the functional pKa of ionizable lipids
    Marius F.W. Trollmann, Paolo Rossetti, Rainer A. Böckmann · 2026 · Biophysical Journal
  11. Detection of ionisable lipids in equine plasma by supported liquid extraction and liquid chromatography-high-resolution tandem mass spectrometry for doping control of mRNA agents
    Bruce Pui‐Nam Yuen, Kin‐Sing Wong, Hiu Wing Cheung, Emmie N. M. Ho, Wing‐Tak Wong · 2026 · Journal of Chromatography A
  12. Overcoming hepatic tropism: Precision engineering of lipid nanoparticles for extrahepatic RNA delivery
    Yu Liu, Xiao Guo, Qin Hu, Chunyuan Gan, Shili Nie, Jingheng Xiang, Yao Liu, Jie Zou, Xintong Wu, Chong Li et al. · 2026 · Materials Today Bio
  13. PRODUCTION OF THERAPEUTIC METHOTREXATE DEGRADING ENZYME AND STUDIES ON ITS NANOCOMPLEXES WITH HUMAN SERUM ALBUMIN
    Venkata Krishna Bayineni, Ravi‐Kumar Kadeppagari · 2016 · International Journal of Pharmacy and Pharmaceutical Sciences
  14. On the prospect of clinical utilization of microRNAs as biomarkers or treatment of chronic pain
    Hjalte Holm Andersen, Kasper Bendix Johnsen, Lars Arendt‐Nielsen · 2016 · Experimental Neurology
  15. Nanomedicine in Nucleic Acid Therapy
    Anisha A. D’souza, Sandhya Pranatharthiharan, Padma V. Devarajan · 2012 · Springer eBooks
  16. Liposomes as vaccine delivery systems
    Ning Wang, Xiaoyan Liu, Xuejiao Ma, Ting Wang · 2024 · Elsevier eBooks
  17. Lipid nanoparticles loaded with anticancer bioactives: state of the art
    Gabriela N. F. Faria, Dhaval Bhavsar, Anupama Munshi, Rajagopal Ramesh · 2024 · Elsevier eBooks
  18. In vivo inhibition of CYP2E1 fails to reduce pulegone-induced liver injury in mice
    Liwen Huan, Yahong Zhang, Wenwen Liu, Hongyu Lu, Cai Zhang, Runting Yin, Zhen Ouyang, Yuan Wei · 2025 · Xenobiotica
  19. Ionization and transfection activity of n-methyl-substituted carbamoyl-cholesterol derivatives
    Samuel Acheampong, Michalakis Savva · 2011 · Journal of Biophysical Chemistry
  20. Polyamine-Based Agents for Gene and siRNA Transfer
    Ian S. Blagbrough, Abdelkader A. Metwally, Osama A. A. Ahmed · 2011 · Royal Society of Chemistry eBooks
  21. Nucleic acid-based vaccines of COVID-19 and their delivery systems
    Haiyin Yang, MengJie Zhang, Yuhua Weng, Yi Cao, Yuanyu Huang · 2021 · Scientia Sinica Vitae
  22. Evaluation of pentaerythritol-based and trimethylolpropane-based cationic lipidic materials for gene delivery
    Shuang Wu, Meiyan Liu, Xiang Hu, Chengxi He, Chunyan Zhao, Shuanglin Xiang, Youlin Zeng · 2022 · Bioorganic & Medicinal Chemistry Letters
  23. Lipid Nanoparticles for the Delivery of Nucleic Acids
    Yuhua Wang, Leaf Huang · 2013 · Pharmaceutical Sciences Encyclopedia
  24. Lipid‐Based Formulations for siRNA Delivery
    Camilla Foged, Pieter Vader, Raymond Michel Schiffelers · 2009
  25. SiRNA Delivery Vehicles
    Aliasger K. Salem, Mark A. Behlke · 2010
  26. Design of Lipid and Polymeric Carriers for Nucleic Acid Delivery
    Lin Zhu · 2010
  27. Lipid nanoparticle delivery of small interfering RNA targeting androgen receptor variants for prostate cancer
    Joslyn Quick · 2019 · cIRcle (University of British Columbia)
  28. Stabilization of Plasmid DNA and Lipid-Based Therapeutics as Dehydrated Formulations
    Marion d.C. Molina, Nicole M. Payton, Thomas J. Anchordoquy · 2015 · Springer eBooks
  29. Design and development of pharmaceutical dosage forms for gene and siRNA delivery
    Hassan M. Ghonaim · 2008 · The University of Bath Online Publications Store (The University of Bath)
  30. Molecular dissection of Bruton s tyrosine kinase signaling in hematopoietic cells using RNAi
    Juhana E. Heinonen · 2007 · Figshare
  31. The Potential and Challenges of siRNA-Based Targeted Therapy for Treatment of Patients with Glioblastoma
    Maïté Verreault, Stephen S. F. Yip, Brian D. Toyota, Marcel B. Bally · 2012 · InTech eBooks
  32. Novel, sequence-defined oligo (ethane amino) amides for siRNA delivery
    Thomas Fröhlich · 2012
  33. Improving treatment outcomes in models of glioblastoma cancer
    Maïté Verreault · 2011 · cIRcle (University of British Columbia)
  34. Anti-GD3 antibodies are targeting molecules for delivery of siRNA to melanoma
    Michael Wing-Yin Wu · 2010 · QSpace (Queen's University Library)
  35. Novel Methods for Delivering and Promoting the Endosomal Escape of Nucleic Acid Based Drugs: Chiral Polyamines and Hydrophobic Nanoparticle-Containing Liposomes
    Verma, Ruchi · 2017
  36. Lipid nanoparticles for delivery of nucleic acid therapeutics
    Sam Chen · 2017 · cIRcle (University of British Columbia)
  37. Investigating alternative delivery systems for self-Amplifying RNA vaccines
    Giulia Anderluzzi · 2019 · STAX
  38. NMA joins coalition to reduce infant mortality.
    R P Epps · 1982 · PubMed Central
  39. Delivery and Formulation Methods for Therapeutic Genome Editing
    Erik Oude Blenke, Venkata Ramanan Krishnamurthy · 2022 · Wiley eBooks
  40. Answering to social issues – Delivery of mRNA vaccines and therapeutics
    Satoshi Uchida · 2022 · Drug Delivery System
  41. Synthetic mRNA Gene Therapies and Hepatotropic Non-viral Vectors for the Treatment of Chronic HBV Infections
    Dylan Kairuz, Prashika Singh, Tiffany S. Smith, Patrick B. Arbuthnot, Abdullah Ely, Kristie M. Bloom · 2022 · RNA technologies
  42. RNA/Polymer-Based Supramolecular Approaches for mRNA Delivery
    Eger Boonstra, Satoshi Uchida, Horacio Cabral · 2022 · RNA technologies
  43. Nanomaterials for Therapeutic Nucleic Acid Delivery
    Shi Du, Jeffrey K. J. Cheng, Yizhou Dong · 2022 · Springer eBooks
  44. Data from PSGL-1 Blockade Induces Classical Activation of Human Tumor-associated Macrophages
    Kevin J. Kauffman, Denise J. Manfra, Dominika Nowakowska, Mohammad R. Zafari, Phuong A. Nguyen, Ryan Phennicie, Elisabeth H. Vollmann, Brian O’Nuallain, Sara Basinski, Veronica Komoroski et al. · 2023
  45. General Workflow for Studying Performance of RNA-Based Lipid Nanoparticles
    Yutian Ma, Shiyao Li, Xin Lin, Yupeng Chen · 2023
  46. Liposomes as DNA, mRNA and oligonucleotide delivery vectors
    Valeria Nele, Virginia Campani, Giuseppe De Rosa · 2024 · Elsevier eBooks
  47. Delivery systems for mRNA
    Anya M Hillery · 2024 · Elsevier eBooks
  48. Spike mRNA Vaccine Encapsulated in a Lipid Nanoparticle Composed of Phospholipid 1,2-Dioleoyl-sn-Glycero-3-Phosphoethanolamine Induced Potent B- and T-cell Responses Associated with Protection against COVID-19 in Hamsters
    Afshana Quadiri, Swayam Prakash, Latifa Zayou, Nisha Rajeswari Dhanushkodi, Amruth Chilukuri, Gemma Ryan, Kelly Wang, Hawa Vahed, Lbachir BenMohamed · 2024 · bioRxiv (Cold Spring Harbor Laboratory)
  49. Nanotechnology for cancer immunotherapy
    Xiaoqi Zheng, Bella B. Manshian, Stefaan J. Soenen · 2025 · Elsevier eBooks
  50. Gene Delivery for Cancer Immunotherapy
    Changrong Wang, Hongzhang Deng · 2025 · Royal Society of Chemistry eBooks
  51. Novel approaches to immuno-oncology
    Rui Chen, Fei Su · 2025 · Elsevier eBooks
  52. Research in mRNA vaccines and delivery carriers
    Wenxi Xie · 2025 · Highlights in Science Engineering and Technology
  53. Lineage of lipid-based endosomal escape in cytosolic delivery to cancer: insight into an unprecedented approach
    Shivani Saraf, Ankita Tiwari, Pritish Kumar Panda, Ankit Jain, Sanjay Jain · 2025 · Journal of Drug Delivery Science and Technology
  54. An overview of strategies and challenges adopted to silence BCR-ABL gene by small interfering RNA
    Laura Fancello, Maria Manconi, María Letizia Manca · 2025 · Nanomedicine
  55. A cell membrane-hybridized nanocarrier-based RNA delivery system for ocular neovascular diseases
    Bojiao Tang, Man-Hong Li, Xianchun Yan, Y C Wang, Jiaxing Sun · 2025 · bioRxiv (Cold Spring Harbor Laboratory)
  56. Investigating the impact of hypoxia and syncytialization on lipid nanoparticle‐mediated mRNA delivery to placental cells
    Rachel E. Young, Tara Vijayakumar, Logan J. Reilley, Krisha Darji, Diya Patel, Samuel I. Hofbauer, Mohamad‐Gabriel Alameh, Drew Weissman, Rachel Riley · 2026 · Bioengineering & Translational Medicine
  57. RNA interference via lipid nanoparticles: An innovative perspective for the treatment of non-small cell lung cancer
    Gabriela Thomazotti Estevez Claro Roberto, Jéssica Fagionato Masiero, Marco Antônio Stephano, Nádia Araci Bou‐Chacra · 2026 · Journal of Drug Delivery Science and Technology
  58. Quantification of membrane translocation and endosomal escape : a chemical biology approach
    Marco Lucchino · 2019
  59. Amphiphilic dendrimers for nucleic acid delivery
    Jiaxuan Chen · 2021 · theses.fr (ABES)
  60. Formulation and stabilization of colloidal polyelectrolyte complexes of chitosan and siRNA
    Tim Delas · 2021
  61. Développement de formulations lipidiques polyvalentes pour la délivrance d'ARN messager : incidence du ciblage du récepteur au mannose des cellules dendritiques et ingénierie des cellules Natural Killer
    Christophe Delehedde · 2023
  62. Développement d’une nouvelle approche thérapeutique basée sur l’interférence à ARN (siRNA) pour traiter les maladies neurodégénératives et les leucodystrophies du système nerveux central
    Guy Khalaf · 2023 · theses.fr (ABES)
  63. Enhanced Intramuscular mRNA Activity of Peptide–Lipid Nanoparticles with Hydrophobized Head Groups
    Eric Weidinger, Tobias Burghardt, Lennart Obeser, Janin Germer, Jana Pöhmerer, Mina Yazdi, Miriam Höhn, Daniel Merk, Ernst Wagner · 2026 · Bioconjugate Chemistry
  64. Design and development of lipid nanoparticle formulations for brain gene therapy
    Sarah B. Thomson, Alissandra de Moura Gomes, Pardis Kazemian, Daniel Z. Kurek, Jayesh A. Kulkarni, Fariba Saadati, Pamela K. Wagner, Terri L. Petkau, Marco A. Ciufolini, Pieter R. Cullis et al. · 2026 · Molecular Therapy — Nucleic Acids
  65. Hydrophobic Tail and Linker Diversification of PEG‐Lipids Unlocks Precise Muscle Tropism of mRNA‐Lipid Nanoparticles
    Bingqian Ou, Xuying Tang, Sunxiang Qian, Bo Chen, Sisi Fang, Jinshuang Su, Xiaopeng Sheng, Jie Feng, Zhefan Yuan, Jing Zhang · 2026 · Small
  66. A double-amine ionizable lipid library enables highly efficient mRNA delivery to T cells at reduced lipid mass
    Vishnu Sriram, Vidya Phatangare, Joo‐Youp Lee · 2026 · Biomaterials Science
  67. A full-flow microfluidic platform for synthesis, purification and concentrating of lipid nanoparticles (LNPs)
    陶剑, Junxiang Zhao, Yuanyuan Liu, Liang Hu, Hongru Zhou, Bohui Wang, Yong Kang · 2026 · Research Square
  68. Development of novel pH-responsive liposomes composed of anionic lipids and pH-sensitive cationic lipids for efficient drug release in weakly acidic environments
    Sae Akaki, Yusuke Kono, Kaho Takakura, Masaki Morishita, Ken‐ichi Ogawara · 2026 · Journal of Pharmaceutical Sciences
  69. RNA-Lipid Interactions Control Structure and Dynamics of Lipid Nanoparticles
    Xiaobing Chen, Cong Xu, Carlos R. Baiz · 2026 · The Journal of Physical Chemistry B
  70. Ionizable Lipid Nanoparticles as a siRNA Delivery Carrier: A Review
    Vishal Prajapat, Gaurav Sharma, Narender K. Dhania, Auhin Kumar Maparu · 2026 · ACS Applied Nano Materials
  71. Brain-informed helper lipid selection enhances intracranial mRNA delivery
    Krisco Cheung, Marcus A. C. Williams, Zuer Wu, Dezhi Liu, Styra Xicun Wang, Bridget McHugo, Pranav Gona, Andrew Li, Burak Baktir, Siyuan Rao et al. · 2026 · Cell Biomaterials