Non-viral is superior to viral gene delivery
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Non-viral vectors may offer advantages over viral vectors for CRISPR/Cas9 delivery, including low immunogenicity, absence of endogenous virus recombination, less limitation in delivering larger genetic payloads, and ease of large-scale production.
“As an alternative, non-viral vectors may offer tantalizing possibility in CRISPR/Cas9 delivery with respect to their low immunogenicity, absence of endogenous virus recombination, less limitation in delivering larger genetic payloads and ease of large-scale production [73–75].”
From Non-viral delivery systems for CRISPR/Cas9-based genome editing: challenges and opportunities (2018) · cites this paper as [74]
Immunogenicity of non-viral vectors is still considered much lower than that of viral vectors.
“Despite all these, the immunogenicity of non-viral vectors is still considered to be much lower than that of viral vectors [74].”
From Non-viral delivery systems for CRISPR/Cas9-based genome editing: challenges and opportunities (2018) · cites this paper as [74]
In contrast with viral vectors, cumulative editing efficacy can be obtained after multiple administrations of non-viral vectors-mediated CRISPR/Cas9 delivery owing to limited immune responses.
“Besides, in contrast with viral vectors, cumulative editing efficacy can be obtained after multiple administrations of non-viral vectors-mediated CRISPR/Cas9 delivery owing to limited immune responses [73, 74, 116, 138].”
From Non-viral delivery systems for CRISPR/Cas9-based genome editing: challenges and opportunities (2018) · cites this paper as [74]
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References 19 · Cited by 225
- Authors
- Li, S.-D., & Huang, L.
- Affiliations
- University of North Carolina at Chapel Hill (US)
- Corresponding author
- Huang, Leaf
- Venue
- Journal of Controlled Release
- Publisher
- Elsevier BV
- Published
- 2007-11
- Volume
- 123
- Issue
- 3
- Pages
- 181-183
- ISSN
- 0168-3659 (ISSN-L)
- OpenAlex
- W2025857959
- Cited by
- 225
- References
- 19
- Citations by year
- 2026: 1 · 2025: 2 · 2024: 4 · 2023: 3 · 2022: 8 · 2021: 12 · 2020: 11 · 2019: 4 · 2018: 8 · 2017: 11 · 2016: 13 · 2015: 19 · 2014: 13 · 2013: 20 · 2012: 27
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Journal of Controlled Release (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › MicroRNA in disease regulation
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › RNA Interference and Gene Delivery
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Virus-based gene therapy research
- Keywords
- non-viral gene delivery, microRNA delivery, colorectal cancer, oncogenic microRNA, drug resistance, nanocarriers, liposomes, micelles, dendrimers, aptamers, polymeric nanoparticles, inorganic nanoparticles, epigenetic regulation, RNA therapeutics, miRNA stability, tumor microenvironment, tumor microvasculature
- MeSH terms
- Animals, Cations, DNA, DNA, Circular, Gene Expression Regulation, Genetic Vectors, Humans, Immunosuppressive Agents, Inflammation, Ligands, Lipids, Liposomes, Polymers, Viruses, Genetic Therapy, Gene Transfer Techniques, CpG Islands, Hepatocytes
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