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Cited by 34Photodynamic Therapy Research StudiesNanoplatforms for cancer theranosticsNanoparticle-Based Drug Delivery

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Tumor delivery of Photofrin® by PLL-g-PEG for photodynamic therapy

Kano, Arihiro, Taniwaki, Yuki, Nakamura, Izumi, Shimada, Naohiko, Moriyama, Kenji, Maruyama, Atsushi·2013·Journal of Controlled Release
DOI 10.1016/j.jconrel.2013.02.016
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Abstract

Photofrin® (porfimer sodium) is a photosensitive reagent used for photodynamic therapy (PDT) of tumors and dysplasias. Because only photo-irradiated sites are damaged, PDT is less invasive than systemic treatments. However, a photosensitive reaction is a major side effect of systemically delivered Photofrin. To enhance localization of Photofrin to tumors, we have formulated Photofrin with the tumor-localizing graft copolymer poly(ethylene glycol)-grafted poly(l-lysine), PLL-g-PEG. We demonstrate that Photofrin preferentially interacts with PLL-g-PEG through both ionic and hydrophobic interactions. The serum competitive study showed that the highly PEG-grafted PLL is better for preventing serum binding to the Photofrin/PLL-g-PEG complex. In tumor-bearing mice, formulation of Photofrin with PLL-g-PEG enhanced tumor localization of Photofrin as twice as Photofrin alone and concomitantly suppressed the photosensitivity reaction drastically.

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Metadata

Authors
Kano, A., Taniwaki, Y., Nakamura, I., Shimada, N., Moriyama, K., & Maruyama, A.
Affiliations
Kyushu University (JP)
Corresponding author
  • Kano, Arihiro
  • Maruyama, Atsushi
ORCID
Venue
Journal of Controlled Release
Publisher
Elsevier BV
Published
2013-05
Volume
167
Issue
3
Pages
315-321
ISSN
0168-3659 (ISSN-L)
DOI
10.1016/j.jconrel.2013.02.016
OpenAlex
W2041519044
Cited by
34
References
0
Citations by year
2026: 1 · 2025: 3 · 2024: 2 · 2023: 2 · 2022: 2 · 2021: 4 · 2020: 1 · 2019: 3 · 2018: 2 · 2017: 2 · 2016: 3 · 2015: 5 · 2014: 3 · 2013: 1
FWCI
3.25
Type
journal article
Language
en
Open access
closed
Licence
Locations
  • Journal of Controlled Release (publishedVersion)
  • PubMed (publishedVersion)
  • Institutional Repositories DataBase (IRDB) (submittedVersion)
  • Tokyo Tech Research Repository (Tokyo Institute of Technology) (submittedVersion)
Funders
  • Japan Society for the Promotion of Science
  • Ministry of Education, Culture, Sports, Science and Technology
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › Photodynamic Therapy Research Studies
  • Physical Sciences › Engineering › Biomedical Engineering › Nanoplatforms for cancer theranostics
  • Physical Sciences › Materials Science › Biomaterials › Nanoparticle-Based Drug Delivery
Keywords
Photofrin, porfimer sodium, photodynamic therapy, tumor targeting, photosensitizer delivery, serum binding, tumor localization
MeSH terms
Animals, Antineoplastic Agents, Blood Proteins, Cell Survival, Light, Liver, Mice, Inbred BALB C, Neoplasms, Photochemotherapy, Polyethylene Glycols, Polylysine, Protein Binding, Photosensitizing Agents, Dihematoporphyrin Ether, Cell Line, Tumor, Mice

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