Organ-on-a-chip platforms for studying drug delivery systems
Open accessAbstract
Novel microfluidic tools allow new ways to manufacture and test drug delivery systems. Organ-on-a-chip systems - microscale recapitulations of complex organ functions - promise to improve the drug development pipeline. This review highlights the importance of integrating microfluidic networks with 3D tissue engineered models to create organ-on-a-chip platforms, able to meet the demand of creating robust preclinical screening models. Specific examples are cited to demonstrate the use of these systems for studying the performance of drug delivery vectors and thereby reduce the discrepancies between their performance at preclinical and clinical trials. We also highlight the future directions that need to be pursued by the research community for these proof-of-concept studies to achieve the goal of accelerating clinical translation of drug delivery nanoparticles.
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References 153 · Cited by 381
- Authors
- Bhise, N. S., Ribas, J., Manoharan, V., Zhang, Y. S., Polini, A., Massa, S., Dokmeci, M. R., & Khademhosseini, A.
- Affiliations
- Brigham and Women's Hospital (US)
- Corresponding author
- Khademhosseini, Ali
- ORCID
- Venue
- Journal of Controlled Release
- Publisher
- Elsevier BV
- Published
- 2014-09
- Volume
- 190
- Pages
- 82-93
- ISSN
- 0168-3659 (ISSN-L)
- PMC
- PMC4142092
- OpenAlex
- W2032088674
- Cited by
- 381
- References
- 153
- Citations by year
- 2026: 8 · 2025: 28 · 2024: 36 · 2023: 27 · 2022: 26 · 2021: 47 · 2020: 38 · 2019: 33 · 2018: 42 · 2017: 38 · 2016: 35 · 2015: 18 · 2014: 4
- FWCI
- 2.71
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Journal of Controlled Release (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Funders
- Office of Naval Research Young National Investigator Award
- National Institutes of Health (HL092836, DE019024, EB012597, AR057837, DE021468, HL099073, EB008392))
- Presidential Early Career Award for Scientists and Engineers
- Portuguese Foundation for Science and Technology (SFRH/BD/51679/2011).)
- Topics
- Physical Sciences › Engineering › Biomedical Engineering › 3D Printing in Biomedical Research
- Physical Sciences › Engineering › Biomedical Engineering › Microfluidic and Capillary Electrophoresis Applications
- Health Sciences › Medicine › Surgery › Tissue Engineering and Regenerative Medicine
- Keywords
- organ-on-a-chip, microfluidics, drug delivery systems, 3D tissue engineering, drug delivery vectors, nanoparticle drug delivery, translational research, drug development
- MeSH terms
- Drug Carriers, Drug Evaluation, Preclinical, Drug Delivery Systems, Biomimetic Materials, Microfluidics, Microfluidic Analytical Techniques, Nanoparticles, Drug Discovery
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