Role of non-covalent and covalent interactions in cargo loading capacity and stability of polymeric micelles
Abstract
Polymeric micelles self-assembled from biodegradable amphiphilic block copolymers have been proven to be effective drug delivery carriers that reduce the toxicity and enhance the therapeutic efficacy of free drugs. Several reviews have been reported in the literature to discuss the importance of size/size distribution, stability and drug loading capacity of polymeric micelles for successful in vivo drug delivery. This review is focused on non-covalent and covalent interactions that are employed to enhance cargo loading capacity and in vivo stability, and to achieve nanosize with narrow size distribution. In particular, this review analyzes various non-covalent and covalent interactions and chemistry applied to introduce these interactions to the micellar drug delivery systems, as well as the effects of these interactions on micelle stability, drug loading capacity and release kinetics. Moreover, the factors that influence these interactions and the future research directions of polymeric micelles are discussed.
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Polymer micelles, comparable in size to lipoproteins and viruses, facilitate cellular uptake through endocytosis, thereby circumventing multidrug resistance associated with conventional drug release approaches.
“Polymer micelles, comparable in size to lipoproteins and viruses, facilitate cellular uptake through endocytosis, thereby circumventing multidrug resistance associated with conventional drug release approaches [204].”
From From design to Deployment: The innovative role of nanomicelles in targeted ophthalmic therapeutics (2025) · cites this paper as [204]
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References 159 · Cited by 146
- Authors
- Ke, X., Ng, V. W. L., Ono, R. J., Chan, J. M. W., Krishnamurthy, S., Wang, Y., Hedrick, J. L., & Yang, Y. Y.
- Affiliations
- National University of Singapore (SG)
- Institute of Bioengineering and Nanotechnology (SG)
- IBM Research - Almaden (US)
- Corresponding author
- Yang, Yi Yan
- Venue
- Journal of Controlled Release
- Publisher
- Elsevier BV
- Published
- 2014-11
- Volume
- 193
- Pages
- 9-26
- ISSN
- 0168-3659 (ISSN-L)
- OpenAlex
- W2079492443
- Cited by
- 146
- References
- 159
- Citations by year
- 2026: 11 · 2025: 12 · 2024: 16 · 2023: 13 · 2022: 11 · 2021: 13 · 2020: 10 · 2019: 11 · 2018: 14 · 2017: 15 · 2016: 11 · 2015: 9
- FWCI
- 4.42
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Journal of Controlled Release (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Institute of Bioengineering and Nanotechnology (Biomedical Research Council, Agency for Science, Technology and Research, Singapore), and IBM Almaden Research Center
- Topics
- Physical Sciences › Materials Science › Biomaterials › Nanoparticle-Based Drug Delivery
- Life Sciences › Pharmacology, Toxicology and Pharmaceutics › Pharmaceutical Science › Advanced Drug Delivery Systems
- Physical Sciences › Chemistry › Organic Chemistry › Advanced Polymer Synthesis and Characterization
- Keywords
- polymeric micelles, non-covalent interactions, covalent interactions, drug loading capacity, micelle stability, drug carriers, drug release kinetics, micelle size distribution
- MeSH terms
- Biocompatible Materials, Drug Carriers, Drug Compounding, Drug Stability, Hydrogen Bonding, Micelles, Particle Size, Polymers, Thermodynamics, Molecular Structure, Hydrophobic and Hydrophilic Interactions, Drug Liberation
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