Light Triggered Oxygen-Affording Engines for Repeated Hypoxia-Resistant Photodynamic Therapy
Abstract
Hypoxia is the trickiest barrier for oncotherapy, which can cause the resistance of various tumor treatments, even promote cancer progression and metastasis, especially in the treatment of photodynamic therapy (PDT). Therefore, alleviating tumor hypoxia would be a favorable modality to improve PDT treatment. In this study, we designed an innovative biological oxygen-evolving material, autotrophic light-triggered green affording‑oxygen engine (ALGAE), which could perform an on-off switchable and inexhaustible oxygen generation triggered by the same irradiation of PDT with good biocompatibility and degradability. And the hypoxia-resistant PDT induced by ALGAE could successfully eradicate tumors and avoid tumor metastasis. The ALGAE system could be standby in a long period for efficient oxygen-affording around tumors, which not only dramatically alleviated tumor hypoxia but also achieved a high-efficiency and repetitive PDT treatments. Furthermore, the innovative biological oxygen-affording engine described in the study presents a new class of oxygen-generating material for hypoxia-resistant cancer therapy.
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A light-triggered oxygen-affording engine using C. pyrenoidosa and Ce6 generated O2 in situ with high controllability and achieved nearly three times more O2 than inorganic oxygen production materials.
“The created engine, which was biocompatible and degradable, could be switched on and off using the same irradiation as PDT and achieve nearly three times more O2 than inorganic oxygen production materials.”
From Emerging Applications of Chlorella sp. and Spirulina (Arthrospira) sp. (2023) · cites this paper as [129]
O2 produced by C. pyrenoidosa could alleviate hypoxia during PDT therapy and effectively eliminate tumor tissues.
“The study demonstrated that the O2 produced by C. pyrenoidosa could alleviate hypoxia during PDT therapy and effectively eliminate tumor tissues.”
From Emerging Applications of Chlorella sp. and Spirulina (Arthrospira) sp. (2023) · cites this paper as [129]
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References 35 · Cited by 104
- Authors
- Zhou, T.-J., Xing, L., Fan, Y.-T., Cui, P.-F., & Jiang, H.-L.
- Affiliations
- China Pharmaceutical University (CN)
- Corresponding author
- Jiang, Hu-Lin
- Venue
- Journal of Controlled Release
- Publisher
- Elsevier BV
- Published
- 2019-08
- Volume
- 307
- Pages
- 44-54
- ISSN
- 0168-3659 (ISSN-L)
- OpenAlex
- W2950454717
- Cited by
- 104
- References
- 35
- Citations by year
- 2026: 6 · 2025: 17 · 2024: 15 · 2023: 15 · 2022: 16 · 2021: 22 · 2020: 12 · 2019: 1
- FWCI
- 4.49
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Journal of Controlled Release (publishedVersion)
- PubMed (publishedVersion)
- Funders
- State Administration of Foreign Experts Affairs (B16046)
- National Natural Science Foundation of China (81773667, 81573369, 81811540416)
- Outstanding Youth Foundation of Jiangsu Province of China (BK20160031)
- Fundamental Research Funds for the Central Universities (2632018PT01, 2632018ZD12)
- Ministry of Education of the People's Republic of China
- National Major Science and Technology Projects of China (2017YFA0205400)
- Topics
- Physical Sciences › Engineering › Biomedical Engineering › Nanoplatforms for cancer theranostics
- Health Sciences › Medicine › Pulmonary and Respiratory Medicine › Photodynamic Therapy Research Studies
- Physical Sciences › Energy › Renewable Energy, Sustainability and the Environment › Advanced Photocatalysis Techniques
- Keywords
- photodynamic therapy, tumor hypoxia, metastasis prevention, cancer therapy
- MeSH terms
- Tumor Hypoxia, Animals, Chlorella, Chlorophyllides, Female, Light, Mice, Inbred BALB C, Neoplasms, Oxygen, Photochemotherapy, Porphyrins, Radiation-Sensitizing Agents, Wound Healing, Reactive Oxygen Species, Cell Line, Tumor
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