Recent advances in colon drug delivery systems
Abstract
As a result of its ability to target certain drugs and/or peptides to the colonic region for the treatment of several diseases while avoiding systemic absorption and potential side effects, colon drug delivery has become a field of research of growing interest. Developing new pharmaceutical formulations capable of reaching the colon requires a broad knowledge of natural and synthetic/semisynthetic polymers. Chitosan, polyethylene-oxide, hydroxypropyl methylcellulose, pectin, natural gums, alginates and polymethacrylates have shown promise when applied in the development of colon drug delivery systems, which range from classic formulation strategies such as tablets and capsules to more sophisticated approaches like nanosystems and integrated osmotic-like formulations. This work aims to bring together knowledge regarding the materials and processes used in the development of such pharmaceutical formulations, as well as to highlight recent advances in the field.
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Colonic drug delivery is beneficial for treating arthritis, angina, nocturnal asthma, and colonic disorders such as colorectal cancer, Crohn's disease, and ulcerative colitis.
“Colonic drug delivery is beneficial for treating arthritis, angina, nocturnal asthma, and colonic disorders such as colorectal cancer, Crohn’s disease, and ulcerative colitis (Arévalo-Pérez et al., 2020; Lee et al., 2020; Naeem et al., 2020; Cui et al., 2021).”
From pH stimuli-responsive hydrogels from non-cellulosic biopolymers for drug delivery. (2023) · cites this paper as Arévalo-Pérez et al., 2020
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References 286 · Cited by 179
- Authors
- Arévalo-Pérez, R., Maderuelo, C., & Lanao, J. M.
- Affiliations
- Universidad de Salamanca (ES)
- Corresponding author
- Maderuelo, Cristina
- Venue
- Journal of Controlled Release
- Publisher
- Elsevier BV
- Published
- 2020-11
- Volume
- 327
- Pages
- 703-724
- ISSN
- 0168-3659 (ISSN-L)
- OpenAlex
- W3086311472
- Cited by
- 179
- References
- 286
- Citations by year
- 2026: 16 · 2025: 44 · 2024: 43 · 2023: 34 · 2022: 23 · 2021: 18
- FWCI
- 1.63
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- Locations
- Journal of Controlled Release (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Pharmacology, Toxicology and Pharmaceutics › Pharmaceutical Science › Advanced Drug Delivery Systems
- Life Sciences › Pharmacology, Toxicology and Pharmaceutics › Pharmaceutical Science › Drug Solubulity and Delivery Systems
- Physical Sciences › Materials Science › Biomaterials › Nanoparticle-Based Drug Delivery
- Keywords
- colon-targeted drug delivery, polymers, chitosan, poly(ethylene oxide), hydroxypropyl methylcellulose, pectin, natural gums, alginate, polymethacrylates, nanosystems, tablets and capsules, local drug delivery
- MeSH terms
- Alginates, Colon, Pectins, Tablets, Drug Delivery Systems
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