The DOI matches its Crossref record; 3 of the 3 references it cites were found in a registry or an index.
Customizing nano-chitosan for sustainable drug delivery
Abstract
Chitosan is a natural polymer with acceptable biocompatibility, biodegradability, and mechanical stability; hence, it has been widely appraised for drug and gene delivery applications. However, there has been no comprehensive assessment to tailor-make chitosan cross-linkers of various types and functionalities as well as complex chitosan-based semi- and full-interpenetrating networks for drug delivery systems (DDSs). Herein, the various fabrication methods developed for chitosan hydrogels are deliberated, including chitosan crosslinking with and without diverse cross-linkers. Tripolyphosphate, genipin and multi-functional aldehydes, carboxylic acids, and epoxides are common cross-linkers used in developing biomedical chitosan for DDSs. Methods deployed for modifying the properties and performance of chitosan hydrogels, via their composite production (semi- and full-interpenetrating networks), are also cogitated here. In addition, recent advances in the fabrication of advanced chitosan hydrogels for drug delivery applications such as oral drug delivery, transdermal drug delivery, and cancer therapy are discussed. Lastly, thoughts on what is needed for the chitosan field to continue to grow is also debated in this comprehensive review article.
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Cites
Kamaly, N., Yameen, B., Wu, J., & Farokhzad, O. C. (2016) · Chemical Reviews · doi:10.1021/acs.chemrev.5b00346 · Cited by 3,070
Deng, Y., Ren, J., Chen, G., Li, G., Wu, X., Wang, G., Gu, G., & Li, J. (2017) · Scientific Reports · doi:10.1038/s41598-017-02962-z · Cited by 178
Complete glutaraldehyde elimination during chitosan hydrogel drying by SC-CO2 processing
Baldino, L., Concilio, S., Cardea, S., De Marco, I., & Reverchon, E. (2015) · The Journal of Supercritical Fluids · doi:10.1016/j.supflu.2015.04.020 · Cited by 103
Metadata
- Authors
- Saeedi, M., Vahidi, O., Moghbeli, M. R., Ahmadi, S., Asadnia, M., Akhavan, O., Seidi, F., Rabiee, M., Saeb, M. R., Webster, T. J., Varma, R. S., Sharifi, E., Zarrabi, A., & Rabiee, N.
- Venue
- Journal of Controlled Release
- Publisher
- Elsevier BV
- Published
- 2022-10
- Volume
- 350
- Pages
- 175-192
- ISSN
- 0168-3659 (ISSN-L)
- OpenAlex
- W4289644953
- Cited by
- 215
- References
- 3
- FWCI
- 13.38
- Type
- journal article
- Language
- en
- Open access
- closed
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- The paper
- Saeedi, M., Vahidi, O., Moghbeli, M. R., Ahmadi, S., Asadnia, M., Akhavan, O., Seidi, F., Rabiee, M., Saeb, M. R., Webster, T. J., Varma, R. S., Sharifi, E., Zarrabi, A., & Rabiee, N. (2022). Customizing nano-chitosan for sustainable drug delivery. Journal of Controlled Release. https://doi.org/10.1016/j.jconrel.2022.07.038
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
