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Cited by 28Bone fractures and treatmentsPeriodontal Regeneration and TreatmentsBone Tissue Engineering Materials

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The role of Platelet Rich Plasma and other orthobiologics in bone healing and fracture management: A systematic review

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Jamal, M.S., Hurley, E.T., Asad, H., Asad, A., Taneja, T.·2022·Journal of Clinical Orthopaedics and Trauma
DOI 10.1016/j.jcot.2021.101759PMC PMC8749440
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Abstract

Background Treatment of large bone defects and fracture healing complications (delayed and non-union) presents a substantial challenge for orthopaedic surgeons. Given that bone healing requires mechanical stability as well as a favourable biological microenvironment, orthobiologics such as Platelet-Rich Plasma (PRP) may have a significant clinical role to play. Aims To perform a systematic review of the available literature to assess the clinical effect of PRP, with or without other orthobiologics, on bone healing. Method Two independent reviewers performed the literature search based on the PRISMA (Preferred Reporting Items for Systematic Reviews and Meta-Analyses) guidelines. Clinical studies of any evidence, assessing effect of PRP with or without other orthobiologics on bone healing, were included. A qualitative analysis was carried out on the clinical and radiological outcomes reported. Result 27 articles with 1631 patients (mean age = 43.56, 57.1% male, mean follow-up = 17.27 months) were included in the qualitative. Of the 27 studies, 13 dealt with fracture complications (delayed or non-unions), 7 with acute fracture healing, 4 with tibial osteotomies and lengthening procedures and 3 with lumbar spine pathology. 18/27 studies showed a clinical benefit of PRP, 8/27 showed no significant effect, and 1/27 showed a worse outcome with PRP. Conclusion Our review suggests PRP may play a clinical role in bone healing but further randomised controlled trials (RCTs) using standardised outcomes should be performed to establish its efficacy.

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Metadata

Authors
Jamal, M. S., Hurley, E. T., Asad, H., Asad, A., & Taneja, T.
Affiliations
  • Queen Mary University of London (GB)
  • NYU Langone Health (US)
Corresponding author
Jamal, M.S.
ORCID
Hurley, E.T.
Venue
Journal of Clinical Orthopaedics and Trauma
Publisher
Elsevier BV
Published
2022-02
Volume
25
Pages
101759
ISSN
0976-5662 (ISSN-L)
DOI
10.1016/j.jcot.2021.101759
PMC
PMC8749440
OpenAlex
W4206772798
Cited by
28
References
0
Citations by year
2026: 4 · 2025: 7 · 2024: 10 · 2023: 2 · 2022: 5
FWCI
0.95
Type
journal article
Language
en
Open access
Licence
Locations
  • Journal of Clinical Orthopaedics and Trauma (publishedVersion)
  • PubMed Central (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Health Sciences › Medicine › Orthopedics and Sports Medicine › Bone fractures and treatments
  • Health Sciences › Dentistry › Periodontics › Periodontal Regeneration and Treatments
  • Physical Sciences › Engineering › Biomedical Engineering › Bone Tissue Engineering Materials
Keywords
platelet-rich plasma, orthobiologics, bone regeneration, fracture healing, delayed union, nonunion, bone defects, tibial osteotomy, bone lengthening, lumbar spine disorders, mechanical stability

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Jamal, M. S., Hurley, E. T., Asad, H., Asad, A., & Taneja, T. (2022). The role of Platelet Rich Plasma and other orthobiologics in bone healing and fracture management: A systematic review. Journal of Clinical Orthopaedics and Trauma. https://doi.org/10.1016/j.jcot.2021.101759